The Philadelphia Regional Stroke Trials Network coordinating Center (PRSTNCC)

费城地区卒中试验网络协调中心 (PRSTNCC)

基本信息

批准号：
8739335
负责人：
SCOTT E KASNER
金额：
$ 39.17万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-30 至 2018-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8739335
关键词：
Academic Medical Centers Adult Age Area Biological Markers Blood Vessels Cause of Death Cerebrovascular Disorders Child Childhood Clinical Clinical Research Clinical Trials Clinical Trials Design Commit Communication Conduct Clinical Trials Data Data Collection Development Discipline Disease Education Emergency Department Physician Emergency treatment Enrollment Feedback Funding Future Generations Goals Hospitals Intervention Knowledge Leadership Mentors Mission Monitor Neurological emergencies Neurologist Neurosurgeon New Jersey Participant Patient Recruitments Patient Transfer Patients Pediatric Hospitals Pennsylvania Phase Philadelphia Positioning Attribute Prevention Principal Investigator Procedures Productivity Prospective Studies Protocols documentation Public Health Recovery Recruitment Activity Rehabilitation therapy Research Research Ethics Research Infrastructure Research Personnel Research Project Grants Research Support Research Training Resources Scientist Site Specialist Stroke Stroke prevention Structure Thrombosis Training Training and Education Translational Research United States Universities Work base career cerebral vein clinical practice data management experience follow-up human subject protection implementation trial innovation member multidisciplinary neonate operation patient population programs public health relevance skills suburb tertiary care treatment trial validation studies

项目摘要

DESCRIPTION (provided by applicant): The proposed Philadelphia Regional Stroke Trials Network Coordinating Center (PRSTNCC) will be a highly effective collaborative stroke research team comprised of adult and pediatric vascular neurologists, neurosurgeons, neuroradiologists, emergency physicians, rehabilitation specialists, and other experts who conduct clinical trials focused on stroke treatment, prevention, and recovery. The PRSTNCC will be based at the University of Pennsylvania (Penn), an urban, tertiary care, academic medical center in Philadelphia, PA, which will serve as the "Hub" of the consortium, and will join forces with the Children's Hospital of Philadelphia (CHOP) and 4 additional member hospitals ("Spokes") located in geographically and ethnically diverse areas in and around Philadelphia. The PRSTNCC thereby unites a comprehensive stroke center, primary stroke centers, and a regional pediatric center, providing access to a broad range of patients with stroke to a multidisciplinary group of clinicians and researchers. The overarching goal of the PRSTNCC is to reduce the burden of stroke among patients of all ages and backgrounds within this region by conducting interdisciplinary trials of promising clinical interventions for stroke treatment, prevention, and recovery. The multi-disciplinary PRSTNCC leadership team, led by Principal Investigator (PI) Scott E. Kasner, MD, has extensive experience conducting multi-center stroke clinical trials, including Cooperative Group trials. The PRSTNCC aims to build on our leadership position within the Greater Philadelphia Southern New Jersey Neurologic Emergencies Treatment Trials Network (GPSNJ-NETT) by creating a similar infrastructure for the efficient conduct of stroke trials among the participant hospitals that are most successful in conducting stroke research. Research support and expertise will be provided by the Hub, particularly in the areas of human subjects protections and other regulatory activities, and education and orientation of clinical and research staff in an effort to streamline trial implementation and expedite patient enrollment. The Hub will provide ongoing support for data collection and transfer during trial execution, and will provide timely feedback and education about trial results to member specialists and hospitals to encourage translation of research results into clinical practice. In addition, we aim to train a new generation of stroke researchers in the conduct and design of clinical trials by providing them with the knowledge and skills necessary for a successful academic career as independently-funded clinician-scientists.

描述（由申请人提供）：拟议的费城地区卒中试验网络协调中心（PRSTNCC）将是一个高效的协作性卒中研究团队，由成人和儿童血管神经科医生、神经外科医生、神经放射科医生、急诊科医生、康复专家和其他专家组成。开展专注于中风治疗、预防和康复的临床试验。 PRSTNCC 将设在宾夕法尼亚大学 (Penn)，这是一个位于宾夕法尼亚州费城的城市、三级护理、学术医疗中心，该中心将作为该联盟的“中心”，并将与费城儿童医院联手(CHOP) 和另外 4 家成员医院（“Spokes”）位于费城及其周边地区和种族多元化的地区。因此，PRSTNCC 联合了综合性卒中中心、初级卒中中心和区域儿科中心，为多学科临床医生和研究人员小组提供了接触广泛卒中患者的机会。 PRSTNCC 的总体目标是通过对中风治疗、预防和康复的有希望的临床干预措施进行跨学科试验，减轻该地区所有年龄和背景的患者的中风负担。由首席研究员 (PI) Scott E. Kasner 医学博士领导的多学科 PRSTNCC 领导团队在开展多中心卒中临床试验（包括合作组试验）方面拥有丰富的经验。 PRSTNCC 旨在通过创建类似的基础设施，在中风研究最成功的参与医院中高效进行中风试验，巩固我们在大费城南新泽西神经急症治疗试验网络 (GPSNJ-NETT) 中的领导地位。。该中心将提供研究支持和专业知识，特别是在人类受试者保护和其他监管活动以及临床和研究人员的教育和指导领域，以简化试验实施并加快患者入组。该中心将为试验执行期间的数据收集和传输提供持续支持，并将提供有关试验结果的及时反馈和教育向成员专家和医院鼓励将研究成果转化为临床实践。此外，我们的目标是培训新一代中风研究人员进行和设计临床试验，为他们提供作为独立资助的临床医生科学家成功学术生涯所需的知识和技能。