Technology for MR brain monitoring

MR脑部监测技术

基本信息

批准号：
10861524
负责人：
Lawrence L Wald
金额：
$ 60.2万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-01 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10861524
关键词：
Abscess Accident and Emergency department Acoustics Ambulances Articulation Beds Brain Brain Diseases Brain Edema Brain Injuries Brain Neoplasms Brain imaging Brain region Caring Cerebrum Clinical Detection Devices Diagnosis Diagnostic Diagnostic Equipment Diameter Diffusion Edema Emergency Care Emergency Medicine Environment FDA approved Geometry Goals Head Height Helmet Hemorrhage Hockey Hour Image Imaging Device Intensive Care Units Intracranial Hemorrhages Intracranial Hypertension Intracranial Pressure Learning Life Location Magnetic Resonance Imaging Maintenance Methods Monitor Neoplasms Nervous System Trauma Neurologic Noise Obstruction Operative Surgical Procedures Patient Monitoring Patients Pharmaceutical Preparations Physiologic pulse RF coil Relaxation Resolution Scanning Shapes Site Sports System Technology Testing Time Transducers Trauma Ventricular Weight Work arm brain magnetic resonance imaging cohort cost design detection platform detector improved light weight magnetic field monitoring device nervous system disorder novel novel strategies patient monitoring device point of care portability power consumption programs prototype rural healthcare standard of care temporal measurement tool ventilation

Abscess Accident and Emergency department Acoustics Ambulances Articulation Beds Brain Brain Diseases Brain Edema Brain Injuries Brain Neoplasms Brain imaging Brain region Caring Cerebrum Clinical Detection Devices Diagnosis Diagnostic Diagnostic Equipment Diameter Diffusion Edema Emergency Care Emergency Medicine Environment FDA approved Geometry Goals Head Height Helmet Hemorrhage Hockey Hour Image Imaging Device Intensive Care Units Intracranial Hemorrhages Intracranial Hypertension Intracranial Pressure Learning Life Location Magnetic Resonance Imaging Maintenance Methods Monitor Neoplasms Nervous System Trauma Neurologic Noise Obstruction Operative Surgical Procedures Patient Monitoring Patients Pharmaceutical Preparations Physiologic pulse RF coil Relaxation Resolution Scanning Shapes Site Sports System Technology Testing Time Transducers Trauma Ventricular Weight Work arm brain magnetic resonance imaging cohort cost design detection platform detector improved light weight magnetic field monitoring device nervous system disorder novel novel strategies patient monitoring device point of care portability power consumption programs prototype rural healthcare standard of care temporal measurement tool ventilation

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项目摘要

Project Summary/Abstract: Technology for MR brain monitoring Magnetic Resonance Imaging (MRI) has been the undisputed standard of care for the detection and diagnosis of neurological disorders and injuries since its inception over 4 decades ago. The cost, weight, size, and maintenance needs of MRI scanners, however, typically precludes their use in some locations with perhaps the greatest need - including Emergency Departments, Neurological Intensive Care Units (ICUs), surgical suites, sports fields, battlefields, rural healthcare sites, and ambulances. This has started to change with the emergence of low-field “point-of-care” scanners, such as those developed by our group and others. Still, even these mobile units are not designed to be used as a patient monitoring device akin to how a pulse-oximeter is used. A new approach is needed to create a true “brain monitor” using MRI. In this work, build on our proof-of-concept prototype 7 kg brain monitor, the “MR Cap” to develop and evaluate an inexpensive device that can be deployed, not bedside, but within the patient bed. Once in place, the device can acquire imaging information at regular intervals and alert the care team to changes associated with increased intracranial pressure or hemorrhage. To achieve this, we relax magnetic field strength and homogeneity constraints to allow lightweight, permanent magnet designs (our prototype is 7 kg) that can be held by an articulating arm with no cryogens or power consumption. We achieve image encoding and eliminate the heavy, power consuming readout gradient by using a built-in gradient requiring no additional power and producing no acoustic noise. We propose passive and active external interference mitigation methods to eliminate the need for a shielded room. We will validate the scanners ability to monitor for and detect cerebral mass effects in the ED and ICU.

项目摘要/摘要：MR大脑监测的技术磁共振成像（MRI）已成为检测无可争议的护理标准以及神经系统疾病和损伤的诊断，自4年前就开始。费用，但是，MRI扫描仪的重量，尺寸和维护需求通常无法在某些人中使用也许最需要的位置 - 包括急诊科，神经密集型护理部门（ICU），外科套房，运动场，战场，粗糙的医疗保健场所和救护车。随着低场“护理点”扫描仪的出现，这种情况已经开始改变由我们的小组和其他人开发。尽管如此，即使这些移动设备也没有被设计为类似于如何使用脉冲氧计的患者监测装置。需要一种新的方法来创建使用MRI的真实“大脑监测器”。在这项工作中，建立在我们的概念证明原型7公斤脑监测器的基础上，“ MR CAP”开发并评估可以部署的廉价设备，而不是床旁，而是在患者床内。到位后，设备可以定期获取成像信息并提醒护理团队与颅内压或出血增加有关的变化。为了实现这一目标，我们放松磁场强度和同质性约束，以允许轻巧的永久磁铁设计（我们的原型是7公斤）可以通过没有冷冻剂或力量的铰接手臂持有消耗。我们实现了图像编码并消除了大量消耗的读数通过使用内置梯度梯度不需要额外的功率，也没有产生声学噪声。我们提出了被动和主动的外部干扰方法，以消除对屏蔽房间。我们将验证扫描仪监测和检测脑质量影响的能力 ED和ICU。