Collaborative Expansion of Marmoset Colonies for Neuroscience Research

用于神经科学研究的狨猴群体的协作扩展

• 批准号: 10882305
• 负责人: Jon E Levine
• 金额: $ 23.7万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-05 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10882305
• 关键词: Acute; Animal Disease Models; Animal Experiments; Animals; Architecture; Behavior; Biological Models; Biomedical Research; Brain; Breeding; Callithrix; Callithrix jacchus jacchus; Caring; Characteristics; Cognition; Collaborations; Communication; Communities; Data; Databases; Discipline; Disease; Embryo; Ensure; Fertility; Genetic Variation; Genomics; Genotype; Growth; Health; Human; Infant; Institution; Life Cycle Stages; Longevity; Mental disorders; Modeling; Neurosciences; Neurosciences Research; Output; Physiology; Primates; Production; Recording of previous events; Records; Reproduction; Research; Research Project Grants; Resources; Rodent Model; Social Behavior; System; Techniques; United States National Institutes of Health; Wisconsin; collaborative approach; gene therapy; genetic pedigree; genome editing; high standard; improved; innovation; mature animal; nonhuman primate; postnatal; prenatal; reproductive; reproductive success; research study; response; social communication; somatic cell gene editing; success; technique development; translational study; young adult

Summary Demand for the common marmoset (Callithrix jacchus) in biomedical research has increased tremendously over the past five years, as they have emerged as a critical biomedical model system in a variety of study disciplines. The increased use of marmosets has been most acute in neuroscience, where the need to study cognition, behavior, and mental illness in primate models has grown. Among non-human primate (NHP) models, the marmoset provides unique practical advantages for neuroscientific studies, including small size, easy handling, rapid reproductive maturation, high fecundity, compressed life cycle, and social behaviors and communication that more closely resemble those observed in humans. These advantages have also contributed to the recent surge in the demand for marmosets in studies using embryonic new genomic editing techniques. This recent upsurge in demand has resulted in shortages in availability of marmosets estimated to be in the range of 2000 marmosets needed by the overall research community each year, with our own estimate in the range of a 200- animal shortfall for the neuroscience community alone. The Southwest National Primate Research Center (SNPRC) and the Wisconsin National Primate Research Center (WNPRC) propose a major collaborative effort to dramatically increase the availability of healthy common marmosets for national neuroscience research projects. In response to the upsurge in demand for marmosets in neuroscience-related projects, the SNPRC and WNPRC propose a comprehensive plan to 1) double their output of marmosets for provision to national institutions in need of these experimental animals for neuroscience research, 2) continue to ensure the highest standards of husbandry and veterinary care and thus, the excellent health of these colonies, 3) maintain pedigree records and develop genomic databases to document and maximize genetic diversity among the expanded marmoset colonies, 4) continue collaboration between the two Centers in new studies focused on improving husbandry, breeding, and veterinary practices to maximize the health and lifespan of these animals, and 5) communicate on a regular basis with the U24 Marmoset Colony Coordination Center, and with the NIH Marmosets for Neuroscience Steering Committee. The collaborative approach proposed by the two NPRCs is both innovative and appropriate given the resources and expertise available and ensures successful completion of these aims resulting in a dramatic increase in the number of marmosets available to the neuroscience community.

概括 生物医学研究中对普通果酱（Callithrix jacchus）的需求大大增加 在过去的五年中，它们已成为各种研究学科中的关键生物医学模型系统。 在研究认知需要的神经科学中，摩尔马群人的使用量增加最为严重的神经科学。 灵长类动物模型中的行为和精神疾病已经发展。在非人类灵长类动物（NHP）模型中 Marmoset为神经科学研究提供了独特的实用优势，包括小尺寸，轻松处理， 快速生殖成熟，高繁殖力，压缩的生命周期以及社会行为和沟通 这更像是在人类中观察到的那些。这些优势也有助于最近 使用胚胎新基因组编辑技术的研究中，对摩尔马人的需求激增。这个最近 需求的兴起导致据估计在2000年范围内可用的摩尔马人的短缺 每年总体研究界都需要的摩尔马人，我们自己的估计在200-2 神经科学界的动物短缺。西南国家灵长类动物研究中心 （SNPRC）和威斯康星州国家灵长类动物研究中心（WNPRC）提出了一项重大合作努力 大大提高健康的普通果果的可用性用于国家神经科学研究 项目。为了回应与神经科学相关项目中对摩尔马人的需求的增长，SNPRC和 WNPRC提出了一个综合计划，以提出1）将其提交给国家的摩尔马斯的产量加倍 需要这些实验动物进行神经科学研究的机构，2）继续确保最高 畜牧业和兽医护理的标准，因此，这些殖民地的出色健康，3）保持血统 记录和开发基因组数据库，以记录和最大化扩展的遗传多样性 Marmoset Colonies，4）继续在新研究中两个中心之间的合作，重点是改进 畜牧，育种和兽医实践，以最大化这些动物的健康和寿命，5） 与U24 Marmoset殖民地协调中心定期沟通，并与NIH进行 神经科学指导委员会的马莫斯人。两个NPRC提出的协作方法是 鉴于可用的资源和专业知识，既有创新又适当的 在这些目的中，可用的神经科学可用的果酱数量急剧增加 社区。

项目成果

Novel Injury Scoring Tool for Assessing Brain Injury following Neonatal Hypoxia-Ischemia in Mice.

• DOI: 10.1159/000525244
• 发表时间: 2022
• 期刊: DEVELOPMENTAL NEUROSCIENCE
• 影响因子: 2.9
• 作者: Ozaydin, Burak;Bicki, Ela;Taparli, Onur E.;Sheikh, Temour Z.;Schmidt, Danielle K.;Yapici, Sefer;Hackett, Margarett B.;Karahan-Keles, Nida;Eickhoff, Jens C.;Corcoran, Karson;Lagoa-Miguel, Claudia;Guerrero Gonzalez, Jose;Dean III, Douglas C.;Sousa, Andre M. M.;Ferrazzano, Peter A.;Levine, Jon E.;Cengiz, Pelin
• 通讯作者: Cengiz, Pelin

TrkB-mediated sustained neuroprotection is sex-specific and ERα dependent in adult mice following neonatal hypoxia ischemia.

TrkB 介导的持续神经保护是性别特异性和 ERα 依赖性的成年小鼠新生缺氧缺血后。

• DOI: 10.21203/rs.3.rs-3325405/v1
• 发表时间: 2023
• 期刊: Research square
• 作者: Chanana,Vishal;Hackett,Margaret;Deveci,Nazli;Aycan,Nur;Ozaydin,Burak;Cagatay,NurSena;Hanalioglu,Damla;Kintner,DouglasB;Corcoran,Karson;Yapici,Sefer;Camci,Furkan;Eickhoff,Jens;Frick,KarynM;Ferrazano,Peter;Levine,JonE;Cengi
• 通讯作者: Cengi