Rickettsiales: Disease Models, Immunity and Vaccine Development

立克次体：疾病模型、免疫和疫苗开发

• 批准号: 8911515
• 负责人: JERE W MCBRIDE
• 金额: $ 1.2万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-06-18 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8911515
• 关键词: Academia; Academy; Address; American; Animal Disease Models; Arthropods; Attention; Award; Bacteria; Biology; California; Cellular biology; Child Care; Collaborations; Communicable Diseases; Communities; Competence; Complex; Development; Diagnostic; Disease; Disease model; Educational workshop; Ensure; Environment; Epidemiology; Faculty; Genomics; Goals; Government; Grant; Human; Immune; Immune response; Immunity; Immunology; Industry; Infection; Institute of Medicine (U.S.); International; Knowledge; Lead; Life; Molecular Biology; Oral; Organism; Participant; Prevention; Production; Recording of previous events; Reporting; Research; Research Personnel; Resolution; Rickettsia Infections; Role; Schedule; Science; Scientific Advances and Accomplishments; Scientist; Services; Site; Societies; Tick-Borne Diseases; Ticks; Time; Travel; Underrepresented Minority; Update; Vaccines; Visual; Work; Zoonoses; biothreat; cost; disorder prevention; interest; meetings; member; mortality; neglect; pathogen; posters; prevent; programs; public health relevance; symposium; vaccine development; vaccinology; vector; vector transmission

 DESCRIPTION (provided by the applicant): The American Society for Rickettsiology (ASR) has a long history of promoting scientific interactions among world-renowned experts and junior investigators to enhance understanding of obligately intracellular bacteria and arthropod-borne rickettsial diseases, which include emerging zoonoses, have important biothreat implications, and are considered neglected. The 27th Meeting of the ASR will be held on June 20-23, 2015 in Olympic Valley, California. This thought-provoking meeting will include a five-session focused workshop titled "Rickettsiales: Disease Models, Immunity and Vaccine Development" to be held in conjunction with the ASR meeting, that will address critical gaps and emphasize the latest advances in models of disease, host responses and immunity, and vaccine development. There is no vaccine for any rickettsial disease, and understanding of protective immunity and immunopathologic immune mechanisms is limited. These gaps in our understanding were recently identified in the 2011 Institute of Medicine (IOM)-sponsored workshop on tick- borne diseases. Keystone conferences are scheduled in 2015 that will address veterinary pathogens and vector transmission, but this proposed workshop is unique in that it is the only one to comprehensively address established and emerging human rickettsial diseases. Topics will include advances in disease models, immunity, and vaccine development, and will thereby address the prevention gap identified in the IOM report. Ten scientists that presented or contributed to the IOM report have agreed to serve on the workshop or scientific committees to ensure that this workshop addresses the gaps identified in the report. The goal of this conference and integrated workshop is to stimulate and facilitate interdisciplinary interactions among junior and established researchers with mutual interests and varied expertise in obligately intracellular pathogen. The expertise of these investigators encompasses the fields of epidemiology, genomics, molecular biology, vector biology, cellular biology, immunology, diagnostics and vaccinology. The conference will provide updates on the state-of-the science, catalyze collaborations, and to identify and develop new strategies to address gaps in disease prevention. Specific objectives of this conference are to provide a forum to encourage scientific exchange among the estimated 200 participants that represent experts from academia, government and industry, through talks by keynote/plenary speakers and by national and international leaders in the field as well as junior scientists and trainees. The conference will also provide a program that will convey cutting-edge scientific advances in rickettsiology and highlights the latest developments in the field, promotes interactions among junior and established investigators through poster sessions, oral presentations and organized networking opportunities. Ample opportunity will be provided to junior scientists and trainees to present thei findings and travel grants awarded to encourage their participation. There will also be strategic efforts to promote attendance and engagement of underrepresented groups in science.

 描述（由申请人提供）：美国立克次体学会 (ASR) 长期以来一直致力于促进世界知名专家和初级研究人员之间的科学互动，以增进对专性细胞内细菌和节肢动物传播的立克次体疾病（包括新出现的人畜共患疾病）的了解，具有重要的生物威胁影响，并被认为被忽视。 ASR 第 27 次会议将于 2015 年 6 月 20 日至 23 日在奥林匹克举行。这次发人深省的会议将包括一个为期五场的重点研讨会，题为“立克次体：疾病模型、免疫和疫苗开发”，该研讨会将与 ASR 会议同时举行，该研讨会将解决关键差距并强调最新进展。疾病模型、宿主反应和免疫以及疫苗开发目前还没有针对任何立克次体疾病的疫苗，并且对保护性免疫和免疫病理学免疫机制的了解是有限的，我们最近在 2011 年发现了这些空白。医学研究所 (IOM) 主办的蜱传疾病研讨会定于 2015 年召开，该研讨会将讨论兽医病原体和媒介传播问题，但此次拟议的研讨会的独特之处在于，它是唯一一个全面讨论现有和新兴人类问题的研讨会。主题将包括疾病模型、免疫和疫苗开发方面的进展，从而解决 IOM 报告中确定的预防差距。 提交或为 IOM 报告做出贡献的 10 名科学家已同意参加研讨会或会议。科学委员会，以确保本次研讨会解决报告中确定的差距。本次会议和综合研讨会的目标是促进和促进在细胞内病原体方面具有共同兴趣和不同专业知识的初级和成熟研究人员之间的跨学科互动。研究人员涵盖流行病学、基因组学、分子生物学、载体生物学、细胞生物学、免疫学、诊断学和疫苗学领域，会议将提供最新科学进展、促进合作，并确定和制定新策略。本次会议的具体目标是提供一个论坛，通过主旨演讲/全体会议发言人以及国家和国际领导人的演讲，鼓励代表学术界、政府和工业界专家的约 200 名与会者进行科学交流。会议还将提供一个项目，传达立克次体学的前沿科学进展，突出该领域的最新发展，通过海报会议、口头报告和交流促进初级和成熟研究人员之间的互动。有组织的网络我们将为初级科学家和受训人员提供充分的机会展示他们的研究成果，并提供旅费补助以鼓励他们参与科学活动。