Comparison of Exercise Mode on Disruptions in Calcium Homeostasis

运动模式对钙稳态破坏的比较

• 批准号: 10835853
• 负责人: Sarah J Wherry
• 金额: --
• 依托单位: VA EASTERN COLORADO HEALTH CARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10835853
• 关键词: Acute; Address; Adult; Age; Age-Related Bone Loss; Aging; Area; Attenuated; Award; Biological Markers; Blood specimen; Bone Density; Bone Resorption; C-telopeptide; Calcium; Cardiometabolic Disease; Clinical; Collagen Type I; Cyclophosphamide; Data; Diabetes Mellitus; Educational Status; Elderly; Exercise; Fracture; Future; Goals; Guidelines; Health; Heart Diseases; Heart Rate; Homeostasis; Hour; Intervention; Knowledge; Life; Life Style; Maximum Heart Rate; Measures; N-terminal; Orthopedics; Osteogenesis; Osteoporosis; Outcome; PTH gene; Participant; Population; Prevention strategy; Procollagen; Quality of life; Randomized; Recommendation; Research; Risk Reduction; Serum; Stimulus; Testing; Time; Type I Procollagen; Veterans; Walking; Weight; Weight-Bearing state; Woman; aged; bone; bone health; bone loss; bone turnover; calcium supplementation; cardiometabolic risk; cardiometabolism; design; endurance exercise; exercise intensity; exercise intervention; exercise prescription; experience; experimental study; fitness; fracture risk; functional independence; improved; innovation; ionization; lifestyle intervention; men; mode of exercise; novel; osteoporosis with pathological fracture; preservation; prevent; release of sequestered calcium ion into cytoplasm; response; response biomarker; sex; treadmill

Endurance exercise is frequently recommended as a means to reduce the risk of cardiometabolic diseases and to reduce the risk of osteoporotic fracture. However, bone does not always adapt in the way that would be expected, and there is evidence that endurance exercise may lead to bone loss under certain conditions. It is our contention that disruptions in calcium homeostasis during exercise, resulting in decreases in serum ionized calcium (iCa) and increases in parathyroid hormone (PTH) and c-telopeptide of type I collagen (CTX; a marker of bone resorption) at the onset of exercise, may be responsible for the lack of improvements in bone mineral density that are anticipated. Acute studies in this area have predominantly focused on young, healthy adults, primarily men, during stationary cycling exercise. Few studies have been conducted in older adults, but those studies have found that older adults experience similar disruptions in calcium homeostasis in response to an acute bout of endurance exercise. Preliminary comparisons of our studies, as well as research from other labs, also suggests that that mode of exercise conducted during these acute exercise bouts may be an important determining factor in the catabolic bone response to exercise. It appears that weight-bearing exercise (i.e., treadmill) results in smaller increases in PTH and CTX compared to weight-supported exercise (i.e., stationary cycling). This has never been tested using a within-subjects design, so it is unclear if these observed differences are due to the mode of exercise, lab-to-lab differences, or other underlying factors. To address this gap in knowledge, 30 Veterans (15 men, 15 women), aged 60+ years, will complete two 1-hour acute exercise bouts: 1) brisk treadmill walking at 70-80% of maximal heart rate; 2) vigorous stationary cycling at 70-80% maximal heart rate. Blood samples will be collected to measure iCa, PTH, CTX and procollagen type I n- terminal propeptide (P1NP) before, during, and after each exercise bout. The order of the exercise bouts will be randomized and counter-balanced. The primary aim is to determine if mode of exercise results in a differential bone biomarker response in older Veterans. This information is essential for understanding how future exercise interventions should be designed to benefit both cardiometabolic health and bone health. This is especially relevant to Veteran health due to the high burden of both cardiometabolic diseases (e.g., diabetes, heart disease) in the population, as well as evidence of increased osteoporotic fracture risk. The proposed research is significant because it is addressing a knowledge gap that has prevented the ability to design exercise and lifestyle interventions aimed at preserving multiple components of Veteran health, which could have a lasting impact on Veteran quality of life and functional independence. The proposed research is innovative because it is testing a novel hypothesis, the mode of exercise on disruptions in calcium homeostasis, in a population that could greatly benefit from the knowledge to be gained. While the proposed research is an acute study, the results generated will be used to design future clinical interventions for Veteran health. Long-term, information gained from this research will help to define the optimal exercise prescription to improve cardiometabolic without compromising bone health aging Veterans.

通常建议耐力运动作为降低心脏代谢疾病风险的一种手段 并降低骨质疏松骨折的风险。但是，骨头并不总是以 预期的，有证据表明耐力运动可能在某些条件下导致骨质流失。这是 我们认为运动过程中钙稳态的干扰，导致血清离子化降低 钙（ICA）和I型胶原蛋白的甲状旁腺激素（PTH）和C-塞肽的增加（CTX；标记物 骨吸收）在运动开始时，可​​能导致骨矿物缺乏改善 预期的密度。该领域的急性研究主要集中在年轻，健康的成年人上 主要是男性，在静止的骑自行车运动中。在老年人中很少进行研究，但是 研究发现，老年人响应于 急性锻炼的急性回合。我们研究的初步比较以及其他实验室的研究 还表明在这些急性锻炼期间进行的运动方式可能很重要 确定分解代谢骨对运动的反应的因素。看来那个体重的运动（即 与体重支持的运动相比，跑步机的PTH和CTX的增加较小（即 骑自行车）。这从未使用过主题内设计对此进行了测试，因此尚不清楚这些是否观察到 差异是由于锻炼方式，实验室到LAB的差异或其他潜在因素所致。解决这个问题 知识差距，30名退伍军人（15名男性，15名女性），年龄在60岁以上，将完成两个1小时的急性锻炼 回合：1）轻快的跑步机以最大心率的70-80％行走； 2）以70-80％的剧烈静止骑行 最大心率。将收集血液样本以测量ICA，PTH，CTX和I型Procollagen 每次锻炼之前，之中和之后，终末前肽（P1NP）。锻炼的顺序将 是随机和平衡的。主要目的是确定运动模式是否导致 老年退伍军人的差异骨生物标志物反应。此信息对于理解如何 未来的运动干预措施应旨在使心脏代谢健康和骨骼健康受益。这 由于两种心脏代谢性疾病的负担很高，与退伍军人健康特别相关（例如 人群中的糖尿病，心脏病），以及骨质疏松骨折风险增加的证据。这 拟议的研究很重要，因为它解决了一个知识差距，这阻止了能力 设计锻炼和生活方式干预措施旨在保留资深健康的多种组成部分， 可能对退伍军人的生活质量和功能独立性产生持久影响。拟议的研究是 创新，因为它正在测试一种新的假设，即钙的破坏方式的运动方式 体内平衡，在人群中可以从获得的知识中受益匪浅。而提议 研究是一项急性研究，产生的结果将用于设计未来的临床干预措施 健康。从这项研究中获得的长期信息将有助于定义最佳的锻炼处方 改善心脏代谢，而不会损害骨骼健康老化的退伍军人。