Developing climate cohorts to understand health associations and resilience and susceptibility factors in Ghana

开发气候队列以了解加纳的健康关联以及复原力和易感性因素

• 批准号: 10838923
• 负责人: Darby Jack
• 金额: $ 57.27万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-07 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10838923
• 关键词: Affect; Africa; African; Age; Air Pollution; Area; Birth; Blood Pressure; Brazil; Cessation of life; Child; Childhood; China; Chronic Disease; Climate; Cohort Studies; Communities; Conceptions; Country; Data; Data Collection; Data Set; Development; Droughts; Educational workshop; Feedback; Future; Ghana; Goals; Government; Growth; Health; Health Promotion; Household; Individual; Life Cycle Stages; Longitudinal cohort; Maps; Maternal and Child Health; Measures; Mentors; Modeling; Morbidity - disease rate; Mothers; Outcome; Participant; Policies; Population; Positioning Attribute; Precipitation; Predisposition; Pregnancy; Proxy; Randomized; Research; Resolution; Resources; Risk; Rural; Scientist; Standardization; System; Temperature; Time; Training; Variant; Work; climate change; climate data; climate policy; climate science; climate-related health; cohort; cost effective; data repository; data resource; disorder risk; extreme heat; follow-up; food security; global health; indexing; insight; large datasets; low and middle-income countries; mortality; novel; prenatal; pressure; prospective; public health intervention; recruit; research and development; resilience; resilience factor; sex; standardize measure; vapor

Project summary Global health gains achieved over the past half century are at risk of being eroded by climate change, which disproportionately affects low- and middle-income countries (LMICs). In LMICs, scientific and policy planning capacity to incorporate climate compatible strategies into climate sensitive areas like the health sector is severely hampered by the lack of empirically derived estimates of local climate sensitivities from their countries and, critical for policy, an understanding of population-specific resilience and susceptibility factors. Indeed, recent climate sensitivities relied on data from LMICs with large scale administrative data (Brazil, China) as a proxy for the African continent. Despite this major limitation, these data suggest that the effect of temperature on mortality in susceptible groups will be ~50% larger in regions for which there is no available data, such as Africa. We propose to build climate science expertise in Ghana by mentored research and the development of two reinforcing sets of “climate cohorts.” We will leverage the well-characterized, extant Ghana Randomized Air Pollution and Health Study to examine associations between climatic exposures on maternal-child health. We will also begin work with the Kintampo Health and Demographic Surveillance System (KHDSS) to prepare for future climate work leveraging this rich data resource. This work will begin to refine climate health sensitivity estimates, provide key insights into resilience and susceptibility factors, and fill urgently-needed policy and practice-relevant evidence gaps. A long-term goal of this project is to provide a framework for continued climate science in Ghana and a model for other African countries with similar extant cohorts, to collectively catalyze climate research on the African continent.

项目摘要 在过去半个世纪中取得的全球健康增长面临着被气候变化侵蚀的风险，这是 不成比例地影响低收入和中等收入国家（LMIC）。在LMIC中，科学和政策计划 将气候兼容策略纳入卫生部门等气候敏感地区的能力是 由于缺乏对本国气候敏感性的经验得出的估计，严重阻碍了其国家 而且，对政策至关重要，对人群特定的弹性和易感因素的理解。的确， 最近的气候敏感性依赖于具有大规模行政数据的LMIC的数据（中国巴西） 代理非洲大陆。尽管这一主要限制，这些数据表明温度的影响 在没有可用数据的地区，易感组的死亡率将大约50％。 非洲。我们建议通过指导研究和发展在加纳建立气候科学专业知识 两套加强“气候人群”。我们将利用特征良好的，现存的加纳随机分组 空气污染和健康研究，以检查气候暴露于母子健康之间的关联。 我们还将开始使用Kintampo健康和人口监视系统（KHDS）来准备 对于未来的气候工作，利用这种丰富的数据资源。这项工作将开始完善气候健康敏感性 估计，提供对弹性和易感因素的关键见解，并填补紧急急需的政策和 实践相关的证据差距。该项目的长期目标是为继续 加纳的气候科学，以及其他具有类似额外队列的非洲国家的模型 催化非洲大陆的气候研究。