Child Lung Development Following a Cookstove Intervention: Evidence from GRAPHS

炉灶干预后儿童肺部发育：来自图表的证据

基本信息

批准号：
10224196
负责人：
Darby Jack
金额：
$ 50.58万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-07-01 至 2023-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10224196
关键词：
6 year old Address Adult Affect Africa Age Air Pollution Biological Birth Cessation of life Child Childhood Chronic Chronic Obstructive Airway Disease Cookstove Data Development Epigenetic Process Exposure to Fire - disasters Future Gases Genetic Transcription Ghana Government Growth Health Heterogeneity Household Air Pollution Impairment Intention Intervention Intervention Trial Knowledge Life Life Cycle Stages Link Liquid substance Literature Lung Lung diseases Measures Mediating Mediation Messenger RNA Methods MicroRNAs Molecular Organ Oscillometry Outcome Pattern Petroleum Placenta Pneumonia Policies Predisposition Pregnancy Prevalence Public Health RNA Randomized Randomized Controlled Trials Research Research Project Grants Respiratory Mechanics Respiratory Signs and Symptoms Risk Role Scanning Smoke Source Spirometry Technology Testing Umbilical Cord Blood Untranslated RNA Wheezing Work ambient air pollution biobank cohort cooking cost effective cost effective intervention design disorder risk early life exposure evidence base follow-up improved in utero insight lung development lung volume novel perinatal period prenatal prenatal exposure pulmonary function respiratory response solid fuel transcriptome treatment arm trial comparing

项目摘要

Project summary Exposure to smoke from cooking fires is among the top five causes of DALYs and death globally, and in Africa in particular. Our proposed study evaluates the impact of these exposures on lung development. To date, most large-scale research on household air pollution (HAP) has focused on childhood pneumonia. Our preliminary data shows, however, that lung function at age one month correlates with HAP exposures in utero. These results are corroborated by a substantial literature that links ambient air pollution exposures to similar outcomes. Decrements in lung function early in life increase risk of COPD and other chronic respiratory diseases. We propose to build on an existing birth cohort in Ghana – the Ghana Randomized Air Pollution and Health Study, or GRAPHS – to assess how early life exposures affect lung function ages 3 and 6. We will use well-established, validated methods to assess these outcomes, and will also measure air pollution exposures at each of these ages. To gain insight into the molecular mechanisms that link HAP exposure to health, we will also study how exposure affects RNA expression in the placenta, and how these epigenetic changes relate to lung function trajectories. In the long run, our research will help build the evidence base for cost effective interventions to improve health by reducing HAP exposure.

项目摘要烹饪大火暴露在全球范围内以及在非洲造成的烟雾是大家庭的前五名原因之一尤其。我们提出的研究评估了这些暴露对肺发育的影响。迄今为止，大多数关于家庭空气污染（HAP）的大规模研究都集中在儿童肺炎上。我们的但是，初步数据表明，一个月大的肺功能与子宫内的HAP暴露有关。这些结果通过大量文献来证实，该文献将环境空气污染的暴露与类似结果。生命早期肺功能的下降增加了COPD和其他慢性呼吸道的风险疾病。我们建议建立在加纳现有的出生队列的基础上 - 加纳随机空气污染和健康研究或图表 - 评估生命早期暴露如何影响3岁和6岁的肺功能。我们将使用建立了良好的，经过验证的方法来评估这些结果，还将测量空气污染暴露在这些年龄中的每个年龄。为了深入了解将HAP暴露与健康联系起来的分子机制，我们将还研究暴露如何影响pleceta中的RNA表达，以及这些表观遗传变化与肺功能轨迹。从长远来看，我们的研究将有助于建立证据基础以实现成本效益通过减少HAP暴露来改善健康的干预措施。