Nanogenerator-Driven Self-Sustainable Power Source for Intracardiac Pacemakers

用于心内起搏器的纳米发电机驱动的自持续电源

基本信息

批准号：
10831936
负责人：
Xudong Wang
金额：
$ 4.42万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-06-01 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10831936
关键词：
Address Adsorption Animals Biology Biomechanics Blood Cardiac Cardiac Surgery procedures Cardiovascular system Charge Clinical Coagulation Process Data Development Device Designs Devices Elastomers Electricity Electrodes Electronics Energy harvesting Engineering Ensure Environment Evaluation Evolution Family suidae Fibrin Frequencies Future Harvest Heart Hemostatic Agents Implant Location Membrane Modeling Monitor Motion Muscle Operative Surgical Procedures Organ Output Pacemakers Physiological Power Sources Proteins Research Right ventricular structure Safety Site Source Surface Surgeon Surgical sutures System Techniques Technology Testing Thrombelastography Thrombosis Time Tissues Work biomaterial compatibility clinically relevant design elastomeric flexibility heart function hemocompatibility implantation improved in vivo in vivo evaluation innovation mechanical properties microelectronics miniaturize multidisciplinary nano nanoscale next generation novel operation porcine model pressure prevent success voltage

项目摘要

Project Summary: Revolutionary advancements in pacemakers include a miniaturized and leadless design and intracardiac implantation. However, the bulky and rigid battery creates the largest hurdle towards further development of a soft system that can be attached and conform to tissue and muscle surfaces without causing unwanted physiologic changes. To address this critical challenge, this project proposes to develop a self-sustainable power source (SSPS) for intracardiac pacemakers using swine models. The SSPS integrates a stretchable, frequency-tuning implantable nanogenerator (i-NG) with a miniaturized supercapacitor and regulating electronics, which can automatically and consistently power a pacemaker by harvesting energy from heartbeats. This project is led by Dr. Wang (PI), with Drs. Hacker and Liu as the co-Is and a cardiac surgeon Dr. Osaki as collaborator, for the development of a flexible i-NG to harvest energy from biomechanical sources. Previous work from Wang and Hacker has confirmed the long-term stability of i-NGs and their negligible impacts on normal heart functions when sutured on swine hearts. Wang has also developed a flexible, micro-grating i-NG capable of converting slow organ motion to continuous alternating current (AC) electricity desired for efficient capacitor charging. Building on these supportive preliminary results, this project focuses on designing and validating a SSPS specifically for powering intracardiac pacemakers by harvesting energy from heartbeats. In Specific Aim 1, we will develop a stretchable SSPS that integrates a flexible i-NG with a commercial supercapacitor and regulating electronics. The membrane i-NG can convert heart beats into continuous, high-frequency AC electricity with an output voltage suitable for efficiently charging the supercapacitor. In Specific Aim 2, we will investigate the bio- and hemo-compatibility of SSPS ex vivo and test the SSPS device in a simulated intracardiac environment. In Specific Aim 3, we will characterize electrical output of SSPS in vivo epicardially in different locations and orientations on the epicardial surface of the right ventricle (RV) of swine hearts. Cardiac function will be monitored over time to ensure SSPS implantation does not alter heart function. The ability to power a commercial pacemaker will also be tested in vivo. In Specific Aim 4, we will investigate intracardiac implantation of SSPS on the internal RV free wall of a surgically removed and beating swine heart on a Langendroff apparatus to test the intracardiac operation ex vivo. This proposed research will develop a novel intracardiac energy harvester that is self-sustainable by harvesting biomechanical energy from heartbeats. Success of this research will establish a technology framework necessary to move rapidly to in vivo intracardiac implantation and testing of SSPS for powering intracardiac pacemakers . This intracardiac energy harvesting technique will present an unprecedented engineering solution to address the power supply challenges for the next generation intracardiac pacemakers by altering flexibility, decreasing size, improving safety, and eliminating the battery component.

项目概要：起搏器的革命性进步包括小型化、无引线设计和心内植入。然而，笨重且刚性的电池给软电池的进一步发展带来了最大的障碍。可以附着并顺应组织和肌肉表面的系统，而不会引起不必要的生理变化变化。为了应对这一严峻挑战，该项目建议开发一种自我可持续的电源（SSPS）用于使用猪模型的心内起搏器。 SSPS 集成了可拉伸的频率调谐具有微型超级电容器和调节电子器件的植入式纳米发电机（i-NG），可以通过从心跳中收集能量，自动持续地为起搏器供电。该项目由王博士（PI）领导，博士生。哈克和刘担任搭档，心脏外科医生大崎博士担任合作者，开发灵活的 i-NG 以从生物力学来源收集能量。之前的作品来自 Wang 和 Hacker 证实了 i-NG 的长期稳定性及其对正常心脏功能的影响可以忽略不计当缝合在猪心脏上时。 Wang 还开发了一种灵活的微光栅 i-NG，能够将慢速器官运动转化为高效电容器充电所需的连续交流电 (AC)。建立在这些支持性的初步结果，该项目侧重于设计和验证专门用于供电的 SSPS 通过从心跳中收集能量来制造心内起搏器。在具体目标 1 中，我们将开发一种可拉伸的 SSPS 它将灵活的 i-NG 与商用超级电容器和调节电子设备集成在一起。 i-NG膜可以将心跳转换为连续的高频交流电，其输出电压适合高效给超级电容器充电。在具体目标 2 中，我们将研究 SSPS 离体的生物和血液相容性并在模拟心内环境中测试 SSPS 装置。在具体目标 3 中，我们将描述电气特性右心室心外膜表面不同位置和方向的体内 SSPS 输出 (RV) 猪心。将随着时间的推移监测心脏功能，以确保 SSPS 植入不会改变心脏功能。为商业起搏器供电的能力也将在体内进行测试。在具体目标 4 中，我们将调查将 SSPS 心内植入手术切除并跳动的猪心脏的右心室游离壁上 Langendroff 装置用于离体测试心内手术。这项拟议的研究将开发一种新型心内能量采集器，通过采集可自我维持来自心跳的生物力学能量。这项研究的成功将建立一个必要的技术框架迅速转向体内心内植入和 SSPS 测试，为心内起搏器供电。这心内能量收集技术将为解决电力问题提供前所未有的工程解决方案通过改变灵活性、减小尺寸、改进设计来应对下一代心内起搏器的挑战安全性，并消除电池组件。

项目成果

期刊论文数量（7）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Stretchable piezoelectric biocrystal thin films.

DOI：
10.1038/s41467-023-42184-8
发表时间：
2023-10-17
期刊：
NATURE COMMUNICATIONS
影响因子：
16.6
作者：
Li, Jun;Carlos, Corey;Zhou, Hao;Sui, Jiajie;Wang, Yikai;Silva-Pedraza, Zulmari;Yang, Fan;Dong, Yutao;Zhang, Ziyi;Hacker, Timothy A.;Liu, Bo;Mao, Yanchao;Wang, Xudong
通讯作者：
Wang, Xudong

Materials Perspectives for Self-Powered Cardiac Implantable Electronic Devices toward Clinical Translation.

DOI：
10.1021/accountsmr.1c00078
发表时间：
2021-09-24
期刊：
Accounts of materials research
影响因子：
14.6
作者：
Li J;Wang X
通讯作者：
Wang X

Stretchable Encapsulation Materials with High Dynamic Water Resistivity and Tissue-Matching Elasticity.

DOI：
10.1021/acsami.2c03110
发表时间：
2022-04-27
期刊：
ACS APPLIED MATERIALS & INTERFACES
影响因子：
9.5
作者：
Shao, Yan;Yan, Shan;Li, Jun;Silva-Pedraza, Zulmari;Zhou, Ting;Hsieh, Marvin;Liu, Bo;Li, Tong;Gu, Long;Zhao, Yunhe;Dong, Yutao;Yin, Bo;Wang, Xudong
通讯作者：
Wang, Xudong

Development of Ferroelectric P(VDF-TrFE) Microparticles for Ultrasound-Driven Cancer Cell Killing.

DOI：
10.1021/acsami.3c13410
发表时间：
2023-11
期刊：
ACS applied materials & interfaces
影响因子：
9.5
作者：
Zulmari Silva Pedraza;Yizhan Wang;Corey Carlos;Zhongmin Tang;Jun Li;Weibo Cai;Xudong Wang
通讯作者：
Zulmari Silva Pedraza;Yizhan Wang;Corey Carlos;Zhongmin Tang;Jun Li;Weibo Cai;Xudong Wang

Long-term in vivo operation of implanted cardiac nanogenerators in swine.

DOI：
10.1016/j.nanoen.2021.106507
发表时间：
2021-12
期刊：
Nano energy
影响因子：
17.6
作者：
Jun Li;T. Hacker;Hao Wei;Yin Long;F. Yang;Dalong Ni;Allison C. Rodgers;W. Cai;Xudong Wang-Xudong-W
通讯作者：
Jun Li;T. Hacker;Hao Wei;Yin Long;F. Yang;Dalong Ni;Allison C. Rodgers;W. Cai;Xudong Wang-Xudong-W