Nanogenerator-Driven Self-Sustainable Power Source for Intracardiac Pacemakers

用于心内起搏器的纳米发电机驱动的自持续电源

• 批准号: 10534064
• 负责人: Xudong Wang
• 金额: $ 7.42万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10534064
• 关键词: 3-Dimensional; 3D Print; Academy; Architecture; Area; Atomic Force Microscopy; Biomechanics; Development; Devices; Diamond; Doctor of Philosophy; Educational process of instructing; Educational workshop; Engineering; Faculty; Film; Future Teacher; Goals; Harvest; Location; Measurement; Mechanics; Mentors; Modulus; Morphologic artifacts; Morphology; NCI Scholars Program; Output; Pacemakers; Phase; Positioning Attribute; Postdoctoral Fellow; Power Sources; Property; Readiness; Research; Research Activity; Resolution; Scanning Probe Microscopy; Slide; Stress; Surface; Testing; Training; Underrepresented Minority; Universities; base; career; design; doctoral student; experience; flexibility; improved; materials science; mechanical behavior; mechanical energy; mechanical properties; member; novel; parent grant; pressure; programs; response

This underrepresented minority (URM) supplement project is proposed for the PhD support for Corey Carlos with a research focus on atomic force microscopy (AFM) study of the mechanical and piezoelectric properties of flexible piezoelectric microstructures, and further improve his professional readiness toward his next academic career step. This research activity represents a logical extension of the fundamental goals outlined in the parent grant (R01HL157077). Specifically, this project explores an alternative approach toward intracardiac mechanical energy harvesting, aimed by the parent grant. While the parent grant focuses on using a sliding mode triboelectric nanogenerator design, this supplemental project will examine a new type of electromechanical materials that may serve as an alternative and promising material candidate for achieving intracardiac energy harvesting. The goal of this supplement project is therefore to test a 3D-printed piezoelectric microlattice that can offer designed mechanical flexibility and strong piezoelectric output under small pressure fluctuations. This study will provide an additional set of novel material options for the design of intracardiac biomechanical energy harvesters. This research goal will be achieved through two specific aims. In specific Aim 1, flexible piezoelectric films with microlattices will be fabricated by 3D printing using a novel piezoelectric composite, which can yield desired structural integrity and well-aligned piezoelectric phase. AFM will be used to characterize the localized mechanical property, and establish a relationship between the microstructure and flexibility to reveal the strain distribution when the microlattice is under pressure. In specific Aim 2, the local piezoelectric property from the microlattice will be characterized by the AFM-based piezoelectric force microscopy (PFM) mode, and correlate to the mechanical behaviors at different locations of the microlattice. Combining these characterization results, we will achieve synergistic optimization of mechanical and piezoelectric properties satisfying the requirements of flexible implantable nanogenerator devices. In the URM supplement project, Mr. Corey Carlos will perform the basic 3D print fabrication and carry out all the proposed AFM-based characterization under the mentoring of PI Wang. This supplement project offers an excellent opportunity for Corey to establish more experiences on soft bio-related materials characterizations and development. It will also help Corey to extend his research portfolio to the areas of biomedical materials and devices – an extremely promising direction that he wants to build his academic career. In the supplement project, Corey will also participate multiple teaching and output programs, including the First Year Faculty Teaching Academy (FYFTA), the WiscProf: Future Faculty in Engineering Workshop, and the Graduate Engineering Research Scholars (GERS) program.

提出了这个代表性不足的少数民族（URM）补充项目 研究重点是原子力显微镜（AFM）研究的机械和压电特性的研究 灵活的压电微观结构，并进一步改善了他的专业准备就绪 职业步骤。这项研究活动代表了父母概述的基本目标的逻辑扩展 格兰特（R01HL157077）。特别是，该项目探讨了一种替代性方法 由父母赠款针对的能量收获。父母的赠款专注于使用滑动模式的底机电极 纳米生物设计，该补充项目将检查一种新型的机电材料 可以作为实现心脏内能量收获的替代和承诺的材料候选者。这 因此，该补充项目的目标是测试可以提供设计的3D打印的压电微型块 在小压力波动下机械柔韧性和强烈的压电输出。这项研究将提供 额外的一组新型材料选择，用于设计心脏内生物力学能量收割机。这 研究目标将通过两个具体目标来实现。在特定的目标1中，带有灵活的压电膜 微片段将通过使用新型的压电复合材料来制造3D打印，该复合材料可以产生所需的 结构完整性和良好的压电阶段。 AFM将用于表征本地化 机械性能，并建立微观结构与灵活性之间的关系以揭示应变 当微观处于压力下时的分布。在特定目标2中，本地压电属性来自 微片段将以基于AFM的压电力显微镜（PFM）模式为特征，并相关 在微观的不同位置的机械行为。结合这些表征结果， 我们将实现满足要求的机械和压电特性的协同优化 柔性植入纳米发育仪设备。在URM补充项目中，Corey Carlos先生将执行 基本的3D打印制造，并在PI的心理下进行所有提议的基于AFM的表征 王。这个补充项目为科里提供了一个绝佳的机会 与生物相关的材料特征和开发。这也将帮助Corey扩展他的研究组合 到生物医学材料和设备的领域 - 他想建立自己的一个非常有希望的方向 学术生涯。在补充项目中，科里还将参加多个教学和产出计划， 包括第一年的教师教学学院（FYFTA），WISCPROF：工程学院未来教师 研讨会和研究生工程研究学者（GERS）计划。