Human Tumor Atlas Network: Data Coordinating Center Extension

人类肿瘤图谱网络：数据协调中心扩展

• 批准号: 10818705
• 负责人: Ethan Cerami
• 金额: $ 200.72万
• 依托单位: DANA-FARBER CANCER INST
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-04 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10818705
• 关键词: Acceleration; Archives; Atlases; Cells; Clinical; Cloud Computing; Collaborations; Communities; Coupled; Dana-Farber Cancer Institute; Data; Data Analyses; Data Commons; Data Coordinating Center; Data Scientist; Development; Documentation; Education and Outreach; Educational Materials; Ensure; Evolution; Fostering; Funding; Genomics; Human; Image; Immunogenomics; Individual; Institution; Intuition; Location; Malignant Neoplasms; Memorial Sloan-Kettering Cancer Center; Molecular; Patients; Performance; Prevention strategy; Procedures; Research; Research Personnel; Research Support; Resistance development; Resources; Services; Slide; Synapses; Systems Biology; Technology; Translational Research; Visualization; Work; anticancer research; application programming interface; cBioPortal; cancer genomics; cancer therapy; centralized portal; cloud based; cloud platform; community building; community involvement; data acquisition; data dissemination; data hub; data management; data portal; data resource; data standards; data submission; data visualization; digital; human genome sequencing; improved; large scale data; novel; open source; operation; outreach program; pathology imaging; radiological imaging; shared database; software development; success; tool; treatment strategy; tumor; tumor progression; tumorigenesis; web portal; working group

Project Summary/Abstract We propose to continue managing the operations of the data coordinating center (DCC) for the Human Tumor Atlas Network (HTAN) with responsibilities for managing, curating, and disseminating the data and resources generated through this network. We have provided, and will continue to provide, key services to organize and support the Research Centers that comprise the network, and foster a community based on collaboration, transparency, and sharing. Our primary scientific objective is to accelerate the discovery of mechanisms governing tumorigenesis, progression, and evolution, which will lead to improved prevention and treatment strategies for patients. We aim to achieve this by providing technology services coupled with best practices to expedite data acquisition and dissemination to HTAN researchers, as well as the broader scientific community. HTAN data is now available via the HTAN Data Portal, the Synapse platform, Minerva, CellXGene, cBioPortal, Google BigQuery, the NCI Cancer Research Data Service (CDS) and the NCI Image Data Commons (IDC). We will continue to release HTAN data to the wider scientific community and further develop visualization, annotation, and analysis tools in order to meet the needs of HTAN and the diverse cancer research community – including data scientists and statisticians to biologists and clinicians – as new types of data are generated.

项目摘要/摘要 我们建议继续管理数据协调中心（DCC）的运营 人类肿瘤地图集网络（HTAN），负有管理，策展和 传播通过此网络生成的数据和资源。我们提供了， 将继续提供组织和支持研究中心的关键服务 包括网络，并根据协作，透明度和 分享。我们的主要科学目标是加速控制机制 肿瘤发生，进展和进化，这将改善预防和治疗 患者的策略。我们旨在通过提供技术服务以及 加快数据获取和传播HTAN研究人员的最佳实践，以及 更广泛的科学界。 HTAN数据现在可以通过HTAN数据门户网站获得 突触平台，密涅瓦，Cellxgene，Cbioportal，Google BigQuery，NCI癌症研究 数据服务（CD）和NCI图像数据共享（IDC）。我们将继续释放 HTAN向更广泛的科学界数据以及进一步的发展可视化，注释和 为了满足HTAN和潜水癌症研究界的需求，分析工具 - 包括数据科学家和统计学家到生物学家和临床医生 - 新类型的数据是 生成。