Ultra-Fast Dose Rate (FLASH) Radiation Detector and Safety System

超快剂量率 (FLASH) 辐射探测器和安全系统

• 批准号: 10714550
• 负责人: RAYMOND BOISSEAU
• 金额: $ 39.79万
• 依托单位: PYRAMID TECHNICAL CONSULTANTS, INC.
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-16 至 2023-06-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10714550
• 关键词: Animals; Clinical; Dependence; Development; Dose; Dose-Rate; Engineering; Environment; Feedback; Future; Goals; Investigation; Normal tissue morphology; Pattern; Phase; Polychlorinated Biphenyls; Protons; Radiation therapy; Reporting; Research; Safety; Scanning; Structure; Suggestion; System; Technology; Test Result; Testing; Time; To specify; Toxic effect; base; density; design; detector; dosimetry; interest; ionization; novel; proton beam; radiation detector

Animal studies show that external-beam radiotherapy reduces normal tissue toxicities when delivered at ultra-high dose rates (>40 Gy/s), a condition referred to as FLASH. The dependence of the FLASH effect on peak dose rate and beam time structure is under intense investigation. An enormous range of peak dose rates has been proposed, leading to research interest in a range of novel detector technologies that are not generally used in clinical dosimetry. We will concentrate on a specific, feasible configuration while still accommodating the full range of detectors under consideration.

动物研究表明，以超高剂量率（> 40 Gy/s）递送时，外束放疗可降低正常的组织毒性，这种疾病称为闪光。闪光效应对峰剂量速率和光束时间结构的依赖性正在进行激烈的研究。已经提出了巨大的峰剂量率，导致对一系列新型检测器技术的研究兴趣，这些技术通常不用于临床剂量测定法。我们将集中精力 一种特定的，可行的配置，同时仍适合正在考虑的全部探测器。