Translational Biomarkers Core

转化生物标志物核心

• 批准号: 10705787
• 负责人: Selena Ahmed
• 金额: $ 16.62万
• 依托单位: MONTANA STATE UNIVERSITY - BOZEMAN
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-15 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10705787
• 关键词: Acceleration; Address; Alaska Native; Alcohol consumption; American Indians; Award; Behavior; Biological Markers; Biomedical Research; Centers of Research Excellence; Chronic Disease; Clinical; Clinical Research; Clinical Trials; Collection; Community Health; Consultations; Development; Diet; Drug usage; Ethics; Evaluation; Face; Faculty; Fees; Food; Funding; Future; Growth Factor; Health; Home; Hormones; Immunoassay; Inflammation; Institution; Intervention Trial; Life Style; Link; Liquid Chromatography; Measurement; Measures; Mentors; Metabolic Diseases; Methods; Mission; Modification; Montana; Observational Study; Oxidative Stress; Patient Self-Report; Performance; Phase; Pilot Projects; Protocols documentation; Reduce health disparities; Research; Research Personnel; Research Project Grants; Resources; Rural Community; Rural Population; Rural health equity; Scientist; Services; Socioeconomic Factors; Specimen Handling; Spectrophotometry; Students; Sustainable Development; Time; Training; Translational Research; Translations; Universities; Work; biomarker validation; community based participatory research; community based research; community center; health disparity; health equity; improved; innovation; instrument; instrumentation; interdisciplinary approach; medical schools; multidisciplinary; nephrotoxicity; prevent; programs; public health research; social; social health determinants; success; therapy development; translational goal; translational research program; underserved community

The overall goal of the Translational Biomarkers Core of the Center for American Indian and Rural Health Equity (CAIRHE) is to help COBRE-supported and other Montana State University (MSU) and regional investigators pursue multidisciplinary biomedical research by providing facilities, instrumentation, analytical services, and mentoring on biomarker assessments for diet, lifestyle, and chronic disease. Carrying out validated and culturally relevant biomedical research addressing social determinants of health is a critical research challenge in the Institutional Development Award (IDeA) state of Montana, which lacks a medical school and is home to Native and rural populations that face significant health disparities. In order to address this need, CAIRHE established the Translational Biomarkers Core during COBRE Phase I to strengthen the biomedical research capacity of its junior investigators and the capacity of other researchers to carry out translational interventions and clinical trials that address health equity. This includes investigators of the Montana IDeA Network for Biomedical Research Excellence (INBRE), the American Indian/Alaska Native Clinical and Translational Research Program (CTRP), and other programs. The Core will pursue the following three Specific Aims that leverage resources of CAIRHE and MSU. Aim 1: The Core will provide and maintain required state-of-the-art instrumentation in support of CAIRHE project leaders and other Center, INBRE, CTRP, and MSU investigators for use in validated biomarker analyses within health equity research projects. Major instruments maintained include a multiplex immunoassay analyzer, dual high- and ultra-performance liquid chromatography module, flow cytometer, spectrophotometer, fluorometer, and real-time PCR unit. Aim 2: The Core will provide lab analytical services to conduct validated biomarker assessments for CAIRHE investigators using Core instrumentation (as described in Aim 1) and protocols. These biomarker assessments will supplement observational and self-reported methods of CAIRHE investigators, providing a multidisciplinary approach that is innovative at MSU for examining social determinants of health. Assessments offered will focus on measurement of diet, lifestyle, and chronic disease biomarkers including inflammation, oxidative stress, hormones, metabolic disease, growth factors, kidney toxicity, and drug and alcohol use. Aim 3: The Core will provide guidance to Center faculty regarding its capabilities, including expertise and consultation on selection and/or modification of biomarker assessments, as well as training on use of instruments and analytical protocols. Ultimately, the Core will work toward the fulfillment of CAIRHE's mission to reduce significant health disparities in Native and rural communities while helping more junior investigators achieve independent status.

美国印第安人和农村健康中心转化生物标志物核心的总体目标 股权（凯尔）将帮助毛绒支持和其他蒙大拿州立大学（MSU）和地区 研究人员通过提供设施，仪器，分析来从事多学科生物医学研究 服务，并指导饮食，生活方式和慢性病的生物标志物评估。进行 经过验证且与文化相关的生物医学研究涉及健康的社会决定因素是至关重要的 蒙大拿州机构发展奖（IDEA）中缺乏医学 学校，是面临重大健康差异的本地和农村人口的所在地。为了解决 这种需求，凯尔（Cairhe 其初级研究人员的生物医学研究能力以及其他研究人员的能力 解决健康公平的转化干预措施和临床试验。这包括 蒙大拿州生物医学研究卓越的想法网络（INBRE），美洲印第安人/阿拉斯加本地人 临床和翻译研究计划（CTRP）和其他计划。核心将追求以下 利用Cairhe和MSU资源的三个具体目标。目标1：核心将提供和维护 需要最先进的仪器，以支持凯尔希项目领导者和其他中心，inbre， CTRP和MSU研究人员用于卫生公平研究项目中经过验证的生物标志物分析。 维持的主要仪器包括多重免疫测定分析仪，双表现 液相色谱模块，流式细胞仪，分光光度计，荧光计和实时PCR单元。目标2： 核心将提供实验室分析服务，以进行经过验证的Cairhe生物标志物评估 研究人员使用核心仪器（如AIM 1中所述）和协议。这些生物标志物评估 将补充凯尔希研究人员的观察和自我报告的方法，提供多学科 在MSU研究健康决定因素方面具有创新性的方法。提供的评估将集中 关于饮食，生活方式和慢性疾病生物标志物的测量，包括炎症，氧化应激， 激素，代谢疾病，生长因子，肾脏毒性以及药物和酒精的使用。目标3：核心将 提供指导，以中心有关其能力的教师，包括有关选择的专业知识和咨询 和/或生物标志物评估的修改以及使用仪器和分析的培训 协议。最终，核心将致力于实现凯尔的使命，以减少重要的健康 土著和农村社区的差异，同时帮助更多的初级调查人员获得独立的地位。