Oxytocin Modulation of Neural Circuit Function and Behavior

催产素对神经回路功能和行为的调节

• 批准号: 10705986
• 负责人: RICHARD W TSIEN
• 金额: $ 486.29万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-15 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10705986
• 关键词: Achievement; Adult; Affect; Animals; Area; BRAIN initiative; Behavior; Behavior Control; Behavioral; Biological; Biophysics; Brain; Brain Diseases; Brain region; Caring; Central Nervous System; Child Rearing; Collaborations; Communication; Communities; Complex; Computer Models; Core Facility; Crying; Data Science; Data Science Core; Decision Making; Development; Ecosystem; Ensure; Environment; Extramural Activities; Fostering; Funding; Goals; Hippocampus; Hormones; Human; Hypothalamic structure; Image; Individual; Infant; Interdisciplinary Study; Investments; Ion Channel; Knowledge; Lateral; Lead; Learning; Literature; Longevity; Mediating; Memory; Mental disorders; Mentors; Methods; Molecular; Mus; Neuronal Plasticity; Neurons; Neuropeptides; Output; Oxytocin; Oxytocin Receptor; Pattern; Peripheral; Physiological; Physiological Processes; Population; Postdoctoral Fellow; Property; Reagent; Reporting; Reproduction; Research Personnel; Research Project Grants; Schizophrenia; Signal Transduction; Social Behavior; Social Dominance; Social Hierarchy; Social Interaction; Social Network; Source; Spatial Behavior; Stimulus; Structure; Students; Synapses; Synaptic Transmission; Synaptic plasticity; System; Techniques; Testing; Therapeutic; Training; Trust; United States National Institutes of Health; Work; animal data; autism spectrum disorder; career development; cognitive function; commune; comparative; data curation; experience; fitness; flexibility; functional outcomes; improved; in vivo; innovation; interdisciplinary approach; interest; medical schools; member; multidisciplinary; neural; neural circuit; neuronal excitability; neuroregulation; next generation; offspring; peptide hormone; public health relevance; repository; selective attention; social; social deficits; social learning; social relationships; sound; spatiotemporal; success; supportive environment; theories; tool

Project Summary Oxytocin is a peptide hormone synthesized and released from the hypothalamus for reproduction, maternal care, and social behavior, as well as various ‘non-social’ aspects of internal state and physiological processes. Although sometimes referred to as a ‘trust’ hormone, a growing body of evidence across species and brain areas indicates that oxytocin can increase social salience, i.e., amplifying or enabling selective attention towards certain social stimuli, such as the sound of a crying infant or the presence of a threatening or high-status individual. Oxytocin is believed to have therapeutic potential, and delivery of oxytocin into the central nervous system promises to improve social deficits in various mental disorders, such as autism. Despite the enthusiasm for oxytocin, contradictory results in the efficacy of oxytocin in improving human social behaviors have been reported. Such inconsistency in literature is likely due to our poor understanding of complexity of oxytocin action, which likely varies with behavioral state, experience and brain structures. We believe that a better understanding of the endogenous action of oxytocin is the key to unleash the therapeutic potential of this highly evolutionary conserved neuropeptide. Advancing our understanding requires cross-level and comparative inter-disciplinary studies by an group of investigators with overlapping interests and the technical capability to analyze oxytocin signaling across molecular, physiological, systems behavioral and levels. This includes multi-animal interactions, as many mental disorders are impactful on social behavior, over the lifespan and throughout the brain. To these ends, this proposed U19 at NYU Grossman School of Medicine on “Oxytocin Modulation of Neural Circuit Function and Behavior” consists of four inter-related Projects and five Core facilities, designated by their responsibilities as Administrative, Behavior, Computational Modeling, Data Science, and Molecular Tools Cores. The overarching goal of the four Projects and Cores is to achieve a better understanding of the oxytocin modulation in socio-spatial behaviors through the development of new tools and theories, which we define as social interactions within a specific context or behavioral environment. Our team will join forces to tackle the oxytocin system from both the source (oxytocin neurons) and the receiving ends (oxytocin receptor-expressing neurons). For Overall Aim 1, Projects 1 and 2 ask how different populations of oxytocin neurons promote stable adult social hierarchy, extending to collective parenting to ensure the survival of offspring as one key advantage of a stable social ecosystem. For Overall Aim 2, Project 3 dives into detailed cellular, synaptic and microcircuit mechanisms that mediate the oxytocin actions. In Overall Aim 3, Project 4 combines knowledge and techniques developed from Projects 1, 2, and 3 to develop methods for specific circuit perturbations to affect socio-spatial learning over multiple spatio-temporal scales. Overall Aim 4 is to ensure that the students, postdocs, and staff team members receive good mentoring and conduct these studies in a supportive pro-social environment.

项目摘要 催产素是一种合成的胡椒马 - 莫恩，并从下丘脑释放，以繁殖，孕产妇护理， 和社会行为，以及内部状态和物理过程的各种“非社会”方面。 尽管有时被称为“信任”激素，但越来越多的物种和大脑区域的证据 表明氧气可以提高社会显着性，即放大或引起选择性的关注 某些社交刺激，例如哭泣的婴儿的声音或威胁或高地位的存在 个人。催产素被认为具有治疗潜力，并将氧气递送到中枢神经系统中 系统有望改善各种精神障碍（例如自闭症）的社会缺陷。尽管有热情 对于氧气，氧气在改善人类社会行为方面的效率矛盾已经存在 报告。在文献中的这种不一致可能是由于我们对氧加毒素作用复杂性的不良理解， 可能会随行为状态，经验和大脑结构而变化。我们相信更好的理解 氧加毒素的内源作用是释放这种高度进化的治疗潜力的关键 保守的神经肽。促进我们的理解需要跨层次和比较跨学科 一组具有重叠兴趣的研究者的研究和分析催产素的技术能力 跨分子，物理，系统行为和水平的信号传导。这包括多动物互动， 由于许多精神障碍对社会行为，整个大脑都有影响。 到这些目的，这是在纽约大学格罗斯曼医学院提出的“催产素调节” 神经电路功能和行为”由四个相互关联的项目和五个核心设施组成 通过他们作为行政，行为，计算建模，数据科学和分子工具的责任 内核。四个项目和核心的总体目标是更好地了解催产素 通过开发新工具和理论，在社会空间行为中调制，我们将其定义为 在特定环境或行为环境中的社交互动。我们的团队将联手解决 来自源（催产素神经元）和接收末端的催产素系统（表达催产素接收器 神经元）。对于总体目标1，项目1和2询问不同种群的氧气神经元如何促进稳定 成人社会等级制度，扩展到集体育儿，以确保后代的生存是一个关键优势 稳定的社会生态系统。对于总体目标2，项目3潜入详细的细胞，突触和微电路 介导氧作用的机制。在总体目标3中，项目4结合了知识和技术 从项目1、2和3开发，以开发特定电路扰动的方法，以影响社会空间 通过多个时空量表进行学习。总体目标4是确保学生，博士后和员工 团队成员在支持的亲社会环境中获得良好的心理，并进行这些研究。