Sex Differences in the Neural Control of Social Behavior; Supplement

社会行为神经控制的性别差异；

基本信息

批准号：
10706016
负责人：
Geert J. De Vries
金额：
$ 4.54万
依托单位：
GEORGIA STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-12-18 至 2024-10-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10706016
关键词：
Ablation Acute Adult Affect Aggressive behavior Agonistic Behavior Amygdaloid structure Area Automobile Driving Behavior Behavior Disorders Behavioral Birds Brain Caspase Cell Nucleus Cells Communication Cre driver Data Excision Female Grant Habenula Impairment Investigation Lateral Measures Medial Mediating Morbidity - disease rate Motivation Mus Nature Output Parents Production RNA Interference Research Rewards Role Sex Differences Sex Differentiation Social Behavior Social Conditions Social Controls Social Environment Social Interaction Stimulus Structure of terminal stria nuclei of preoptic region System Testing Urine Vasopressins Vertebrates Viral Work affiliative behavior autism spectrum disorder conditioned place preference genetic approach knock-down male mature animal mind control nerve supply neural neural circuit neuroregulation optogenetics sex sexual dimorphism sexual role social social engagement

项目摘要

PROJECT SUMMARY This project aims to understand the function of sex differences in neural control of social behavior by focusing on the higher level of vasopressin expression in male versus female brains. This is the most consistently found sex difference among vertebrates, and the best understood in terms of function in adult animals. This grant will study whether the sex difference in vasopressin innervation contributes to sex differences in the display and control of social behavior. We will take advantage of new powerful genetic approaches that allows us to target vasopressin cells specifically. The first aim is to test whether concurrent removal of the sexually dimorphic vasopressin cells in the bed nucleus of the stria terminalis and medial amygdaloid nucleus affects social behavior differently in males and females. The second aim is to test whether inhibition or excitation of these cells alters social behavior differently in males and females. The third aim is to identify the in- and outputs of these cells, to begin to understand the neural circuitry via which vasopressin affects social behavior differently in males and females. Understanding how the brain controls social behavior differently in males and females as many behavioral disorders show striking sex differences in morbidity. Sexual differentiation of the brain likely contributes to these differences. Although recently major advances have been made in understanding the neural basis of social behavior in adulthood, how such behavior is controlled differently in males and females is, by and large, unknown. This grant will address these issues.

项目摘要该项目旨在了解性别差异在神经控制社会行为中的功能专注于雄性与雌性大脑中加压素表达的较高水平。这是最大的始终发现脊椎动物之间的性别差异，并且在功能方面最能理解成年动物。该赠款将研究加压素神经的性别差异是否有助于在社会行为的表现和控制中的性别差异。我们将利用新的功能遗传方法使我们能够特别靶向加压素细胞。第一个目的是测试是否同时除去质末端的床核中的性二态加压素细胞内侧杏仁核核对男性和女性的社会行为影响不同。第二个目标是测试对这些细胞的抑制或激发在男性中改变社会行为的改变，并且女性。第三个目的是识别这些细胞的内部和输出，开始理解神经加压素在男性和女性中对社会行为的影响不同的电路通过。理解大脑在男性和女性中如何以多种行为障碍的方式控制社会行为在发病率上显示出惊人的性别差异。大脑的性别差异可能会导致这些差异。尽管最近在理解神经基础方面取得了重大进展成年后的社会行为，这种行为在男性和女性中如何受到不同的控制大，未知。该赠款将解决这些问题。