Obesity, sedentary behaviors, and diet quality for prevention and early detection of early-onset colorectal neoplasia
肥胖、久坐行为和饮食质量有助于预防和早期发现早发性结直肠肿瘤
基本信息
- 批准号:10688157
- 负责人:
- 金额:$ 52.16万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-07-01 至 2025-06-30
- 项目状态:未结题
- 来源:
- 关键词:AdultAfrican AmericanAgeAmerican Cancer SocietyArchivesBioinformaticsBiological MarkersBloodCarcinomaClinicalCohort StudiesCollaborationsColonColorectalColorectal CancerCommunitiesComplementDataDecision ModelingDiabetes MellitusDiagnosticDietEarly DiagnosisEarly identificationEndotoxemiaEndotoxinsEpidemiologyEtiologyGuidelinesHigh Fat DietHistologyImmune responseIncidenceInflammationInflammatory Bowel DiseasesInvestigationLifeLife Cycle StagesLife StyleLife course epidemiologyLinkLongevityMeasurementMediatingMeta-AnalysisModelingMolecularNeoplasmsNurses&apos Health StudyObesityPathologicPathway interactionsPlasmaPlayPopulationPositioning AttributePreventionProcessProspective cohortProteomicsRecommendationRelative RisksReportingResearch PersonnelResearch PriorityResourcesRiskRisk FactorsRoleTestingTimeUnhealthy DietUpdateadenomabiomarker discoverycancer diagnosiscarcinogenesiscirculating biomarkerscolon carcinogenesiscolon tumorigenesiscolorectal cancer screeningcostcost efficientearly onsetearly onset colorectal cancerearly onset colorectal neoplasmemerging adultgut dysbiosisimprovedinflammatory markerinsightlifestyle datalifestyle factorsmicrobialmodels and simulationmultidisciplinarynovelnovel markerpersonalized screeningprospectiveprotein protein interactionscreeningscreening guidelinessedentarysedentary lifestylesimulationsystematic reviewsystemic inflammatory responseyoung adult
项目摘要
PROJECT SUMMARY/ABSTRACT
The rising incidence in early-onset colorectal cancer (CRC diagnosed before 50), has resulted in updated
American Cancer Society (ACS) guideline advising average-risk screening begin at age 45, rather than 50.
Debates centered around the substantial cost and resources of adding 21 million adults at very low risk to the
screening pool, and “further personalize screening strategies” was a priority. Identifying the contributors of the
rising incidence are the first steps but thus far an unmet need. Lifestyle factors that preceded and mirrored the
rapid rise of early-onset CRC, including obesity, prolong sitting, and poor diet, may play a critical role. Our
preliminary data support the importance of obesity and sedentary behaviors and early-onset CRC are more likely
to be processed from traditional adenoma-carcinoma sequence compared to CRC diagnosed after age 65.
Therefore, investigation into risk factors for early-onset advanced adenoma, the major targets of screening, will
illuminate insights of colorectal carcinogenesis at younger ages. Accumulating data suggest that microbial
translocation/endotoxemia, which triggers subsequent inflammation and immune response, and augmented by
above-mentioned lifestyle factors, might be an emerging pathway. We hypothesized that obesity, prolonged
sitting, and poor diet quality increase risk of early-onset advanced adenoma through increasing endotoxemia
and inflammation, and contribute to the rise of early-onset CRC. To test these hypotheses, we will leverage
lifestyle data collected throughout life course in two well-characterized prospective cohort (Nurses’ Health Study
II [NHSII]) and Southern Community Cohort Study (SCCS) with archived pre-diagnostic blood, complemented
by decision modeling using the Microsimulation Screening Analysis‐Colon (MISCAN‐Colon), the model used to
inform the ACS screening guideline. Specifically, we will first examine prospectively the associations between
mid-adulthood and early-life obesity, sedentary behaviors, and diet quality and risk of early-onset advanced
adenoma (Aim 1). We will then investigate into the independent and mediating role of pre-diagnostic plasma
markers of endotoxemia and inflammation in early-onset neoplasia, leveraging a cost-efficient and reliable
proteomic platform. Such profiling will also allow for untargeted discoveries of protein-protein interactions to
identify novel networks/targets (Aim 2). Finally, we will conduct a meta-analysis to identify early-onset CRC
specific risk factors and quantify the relative risks, and integrate these findings to the MISCAN-Colon to estimate
the contributions of secular changes of lifestyle to the rise of early-onset CRC and to improve the simulations
used to support the 2018 ACS screening guideline using early-onset CRC specific risk factors/estimates (Aim
3). Our established team, led by an early stage investigator focused on early-onset CRC, and leaders in
epidemiology, bioinformatics, biomarker measurement and discoveries, and decision modeling, offers
unparalleled expertise. This investigation will illuminate significant insights into the etiology of early-onset CRC
and will be a significant step forward to optimal/personalized CRC screening among younger adults.
项目概要/摘要
早发性结直肠癌(50 岁之前诊断出的结直肠癌)发病率不断上升,导致更新
美国癌症协会 (ACS) 指南建议平均风险筛查从 45 岁开始,而不是 50 岁。
争论的焦点是增加 2100 万风险极低的成年人,需要大量成本和资源。
筛选池和“进一步个性化筛选策略”是当务之急。
发病率上升是第一步,但迄今为止,生活方式因素尚未得到满足。
早发性结直肠癌的迅速增加,包括肥胖、久坐和不良饮食,可能发挥着关键作用。
初步数据支持肥胖和久坐行为的重要性,并且更有可能发生早发性结直肠癌
与 65 岁后诊断出的 CRC 相比,根据传统的腺瘤-癌序列进行处理。
因此,作为筛查的主要目标,调查早发晚期腺瘤的危险因素将有助于
阐明年轻时结肠直肠癌发生的见解。积累的数据表明微生物。
易位/内毒素血症,引发随后的炎症和免疫反应,并通过
上述生活方式因素,可能是导致肥胖持续时间延长的一个新途径。
久坐和不良饮食质量会增加内毒素血症,从而增加早发晚期腺瘤的风险
和炎症,并导致早发性结直肠癌的增加。为了检验这些假设,我们将利用这一点。
在两个特征明确的前瞻性队列中收集整个生命过程的生活方式数据(护士健康研究
II [NHSII])和南部社区队列研究(SCCS),使用存档的诊断前血液进行补充
通过使用微观模拟筛选分析-Colon (MISCAN-Colon) 进行决策建模,该模型用于
具体来说,我们将首先前瞻性地检查之间的关联。
中年和早期肥胖、久坐行为、饮食质量和早发晚期的风险
然后我们将研究诊断前血浆的独立和中介作用。
早发性肿瘤中内毒素血症和炎症的标志物,利用具有成本效益且可靠的方法
蛋白质组学平台也将允许非针对性地发现蛋白质-蛋白质相互作用。
最后,我们将进行荟萃分析来识别早发性 CRC。
特定风险因素并量化相对风险,并将这些发现整合到 MISCAN-Colon 中进行估计
生活方式的长期变化对早发性结直肠癌的增加的贡献以及改进模拟
用于支持 2018 年 ACS 筛查指南,使用早发 CRC 特定风险因素/估计(目标
3). 我们建立的团队由专注于早发性 CRC 的早期研究人员和领导者领导
流行病学、生物信息学、生物标志物测量和发现以及决策建模,提供
这项研究将揭示对早发性结直肠癌病因的重要见解。
这将是在年轻人中实现最佳/个性化 CRC 筛查的重要一步。
项目成果
期刊论文数量(8)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Vitamin D and Early-Onset Colorectal Cancer-Rays of Hope?
维生素 D 和早发性结直肠癌——希望之光?
- DOI:10.1053/j.gastro.2023.08.002
- 发表时间:2023
- 期刊:
- 影响因子:29.4
- 作者:Cao,Yin;Chan,AndrewT
- 通讯作者:Chan,AndrewT
Rising incidence of early-onset colorectal cancer - a call to action.
- DOI:10.1038/s41571-020-00445-1
- 发表时间:2021-04
- 期刊:
- 影响因子:0
- 作者:Akimoto N;Ugai T;Zhong R;Hamada T;Fujiyoshi K;Giannakis M;Wu K;Cao Y;Ng K;Ogino S
- 通讯作者:Ogino S
Obesity and Gastrointestinal Cancer: A Life Course Perspective.
肥胖和胃肠癌:生命历程的视角。
- DOI:10.1001/jamanetworkopen.2023.9921
- 发表时间:2023
- 期刊:
- 影响因子:13.8
- 作者:Shi,Mengyao;Cao,Yin
- 通讯作者:Cao,Yin
Alcohol Drinking Without Meals Is Associated With Risk of Gastrointestinal Cancers, Including Early-Onset Cases.
不进餐饮酒与胃肠道癌症(包括早发病例)的风险相关。
- DOI:10.1053/j.gastro.2023.11.012
- 发表时间:2024
- 期刊:
- 影响因子:29.4
- 作者:Shi,Mengyao;Ahmedin,NadiaJ;Zong,Xiaoyu;Yilmaz,ӦmerH;Bishehsari,Faraz;Cao,Yin
- 通讯作者:Cao,Yin
Elucidating the Drivers for the Rising Incidence of Early-Onset Colorectal Cancer: How Ecologic Studies Could Help and What Is Next.
阐明早发性结直肠癌发病率上升的驱动因素:生态学研究如何提供帮助以及下一步。
- DOI:10.1158/1055-9965.epi-22-1126
- 发表时间:2023
- 期刊:
- 影响因子:0
- 作者:Ni,Peiyun;Lansdorp-Vogelaar,Iris;Zauber,AnnG;Cao,Yin
- 通讯作者:Cao,Yin
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Yin Cao其他文献
Yin Cao的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Yin Cao', 18)}}的其他基金
Obesity, sedentary behaviors, and diet quality for prevention and early detection of early-onset colorectal neoplasia
肥胖、久坐行为和饮食质量有助于预防和早期发现早发性结直肠肿瘤
- 批准号:
10192685 - 财政年份:2020
- 资助金额:
$ 52.16万 - 项目类别:
Alcohol, Gut Dysbiosis, Endotoxemia, and Colorectal Cancer
酒精、肠道菌群失调、内毒素血症和结直肠癌
- 批准号:
9895402 - 财政年份:2020
- 资助金额:
$ 52.16万 - 项目类别:
Obesity, sedentary behaviors, and diet quality for prevention and early detection of early-onset colorectal neoplasia
肥胖、久坐行为和饮食质量有助于预防和早期发现早发性结直肠肿瘤
- 批准号:
10438561 - 财政年份:2020
- 资助金额:
$ 52.16万 - 项目类别:
Optimizing the Impact of Aspirin for Chemoprevention
优化阿司匹林对化学预防的影响
- 批准号:
10212338 - 财政年份:2018
- 资助金额:
$ 52.16万 - 项目类别:
相似海外基金
Developing Real-world Understanding of Medical Music therapy using the Electronic Health Record (DRUMMER)
使用电子健康记录 (DRUMMER) 培养对医学音乐治疗的真实理解
- 批准号:
10748859 - 财政年份:2024
- 资助金额:
$ 52.16万 - 项目类别:
Increasing initiation of evidence-based weight loss treatment
越来越多地开始开展循证减肥治疗
- 批准号:
10735201 - 财政年份:2023
- 资助金额:
$ 52.16万 - 项目类别:
StuDy AimED at Increasing AlCohol AbsTinEnce (DEDICATE)
旨在提高酒精戒断率的研究(奉献)
- 批准号:
10577022 - 财政年份:2023
- 资助金额:
$ 52.16万 - 项目类别:
Racial Disparities in Alzheimer's Disease and Related Dementias: The Role of School Segregation and Experiences of Discrimination
阿尔茨海默病和相关痴呆症的种族差异:学校隔离的作用和歧视经历
- 批准号:
10606362 - 财政年份:2023
- 资助金额:
$ 52.16万 - 项目类别:
A Low-Cost Wearable Connected Health Device for Monitoring Environmental Pollution Triggers of Asthma in Communities with Health Disparities
一种低成本可穿戴互联健康设备,用于监测健康差异社区中哮喘的环境污染诱因
- 批准号:
10601615 - 财政年份:2023
- 资助金额:
$ 52.16万 - 项目类别: