Pediatric Recovery After Sepsis Treatment in the Pediatric Intensive Care Unit

儿科重症监护病房脓毒症治疗后的儿科康复

• 批准号: 10688179
• 负责人: MALLORY A PERRY-EADDY
• 金额: $ 24.9万
• 依托单位: UNIVERSITY OF CONNECTICUT STORRS
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10688179
• 关键词: Acute Lung Injury; Address; Adult; Age; Award; Biological; Biological Markers; Biometry; C-reactive protein; Career Transition Award; Cause of Death; Child; Childhood; Communities; Complement; Complex; Critical Care; Critical Illness; Critically ill children; Data; Data Set; Development; Early Intervention; Early identification; Education; Environment; Evaluation; Evolution; Family; Functional disorder; Future; Genetic Markers; Genetic Variation; Genotype; Growth and Development function; Health; Hospitals; Iatrogenesis; Immersion; Individual; Infection; Inflammation; Inflammation Mediators; Inflammatory; Intensive Care; Interleukin-6; Interleukin-8; Intervention; Knowledge; Longitudinal cohort study; Measures; Mentors; Mentorship; Mission; Modeling; Morbidity - disease rate; Muscular Atrophy; National Institute of Nursing Research; Nature; Nurses; Pediatric Hospitals; Pediatric Intensive Care Units; Pediatrics; Pennsylvania; Performance; Phase; Phenotype; Philadelphia; Physical Function; Positioning Attribute; Postdoctoral Fellow; Predictive Analytics; Quality of life; Randomized; Recovery; Rehabilitation therapy; Reporting; Research; Research Design; Research Personnel; Respiratory Failure; Risk; Role; Sampling; Scientist; Sedation procedure; Sepsis; Site; Statistical Methods; Survivors; Syndrome; Techniques; Titrations; Training; Universities; Validation; Vulnerable Populations; Work; biobank; biobehavior; career; cohort; experience; follow-up; improved; meetings; model development; pediatric sepsis; pre-doctoral; programs; prospective; skills; symposium; symptom science; wasting

PROJECT SUMMARY/ABSTRACT Sepsis in children is a leading cause of death and morbidity, yet little is known about its impact on physical function after hospital discharge. Building upon the candidate’s prior biobehavioral research, this proposed K99/R00 application will utilize symptom science approaches to explore the potential role of pro-inflammatory mediators as they pertain to physical function in critically ill children who survive sepsis. This proposed application aligns well with the mission of the National Institute for Nursing Research, “to promote and improve the health and quality of life of individuals, families and communities.” The overall purpose of this K99/R00 application, Maximizing Opportunities for Scientific and Academic Independent Careers (MOSAIC) Postdoctoral Career Transition Award to Promote Diversity (PAR-19-343), is to prepare the candidate for an independent career as a nurse scientist with a robust program of research in pediatric critical care and symptom science. In the initial mentored phase (K99), the candidate will utilize existing data to (A1) develop PEdiatric Recovery after sepSIS Treatment in the Pediatric Intensive Care Unit (PERSIST-PICU), a multivariable model to identify risk physical dysfunction risk in critically ill children who survive sepsis. Sub aims include (A1.1) associating the critically ill child’s course of illness with physical function after PICU discharge; and (A1.2) associating the role of inflammation during critical illness on physical function after PICU discharge. The candidate will develop a model through advanced statistical methods to identify children who are a-risk for physical dysfunction after PICU discharge. In the independent phase (R00), the candidate will conduct a prospective longitudinal cohort study to (A2) refine PERSIST-PICU model with new biological measures of inflammation. Identification of critically ill children with sepsis who are at-risk for physical dysfunction after discharge will provide an opportunity for early intervention to optimize their physical function after critical illness. The mentored phase of this award (K99) will include training by a well-crafted, interprofessional team of scientists who are experts in the proposed study design and advanced biostatistical modeling of inflammatory biomarkers in pediatric critical care. In addition, the candidate has proposed an individualized training plan to meet her unique training needs. The training plan includes attendance at the MOSAIC UE5 educational conference, seminars, scientific meetings and targeted coursework. The candidate’s stellar mentorship team, tailored research plan and findings within this K99/R00 application will prepare her well for transition to independence as a nurse scientist in pediatric critical care and symptom science.

项目概要/摘要 儿童脓毒症是死亡和发病的主要原因，但人们对其对身体的影响知之甚少。 根据候选人之前的生物行为研究，提出了出院后的功能。 K99/R00 应用将利用症状科学方法来探索促炎症的潜在作用 介质，因为它们与脓毒症幸存的危重儿童的身体功能有关。 该应用程序与国家护理研究所的使命非常契合，“促进和改善 K99/R00 的总体目标是个人、家庭和社区的健康和生活质量。 申请，科学和学术独立职业机会最大化（MOSAIC） 促进多元化的博士后职业转型奖（PAR-19-343），旨在帮助候选人做好准备 作为一名护士科学家，拥有独立的职业生涯，在儿科重症监护和 在最初的指导阶段 (K99)，候选人将利用现有数据 (A1) 进行开发。 在儿科重症监护病房 (PERSIST-PICU) 进行脓毒症治疗后的儿科康复， 多变量模型来识别脓毒症幸存的危重儿童的身体功能障碍风险。 包括 (A1.1) 将危重儿童的病程与 PICU 出院后的身体机能联系起来； (A1.2) 将危重病期间炎症的作用与 PICU 出院后的身体功能联系起来。 候选人将通过先进的统计方法开发一个模型来识别有风险的儿童 PICU 出院后的身体功能障碍 在独立阶段 (R00)，候选人将进行一次身体功能障碍检查。 前瞻性纵向队列研究 (A2) 通过新的生物学测量来完善 PERSIST-PICU 模型 识别患有败血症的危重儿童，这些儿童在术后有身体功能障碍的风险。 出院将为早期干预提供机会，以优化危重患者的身体机能 该奖项（K99）的指导阶段将包括由精心设计的跨专业团队进行的培训。 拟议的研究设计和先进的炎症生物统计模型方面的专家科学家 此外，候选人还提出了一个个性化的培训计划。 满足她独特的培训需求 培训计划包括参加 MOSAIC UE5 教育课程。 会议、研讨会、科学会议和有针对性的课程作业，候选人的一流指导团队， K99/R00 应用程序中的定制研究计划和研究结果将为她过渡到做好准备 独立作为儿科重症监护和症状科学领域的护士科学家。