Pediatric Recovery After Sepsis Treatment in the Pediatric Intensive Care Unit

儿科重症监护病房脓毒症治疗后的儿科康复

• 批准号: 10451762
• 负责人: MALLORY A PERRY-EADDY
• 金额: $ 0.08万
• 依托单位: CHILDREN'S HOSP OF PHILADELPHIA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2022-08-03
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10451762
• 关键词: Acute Lung Injury; Address; Adult; Age; Award; Biological; Biological Markers; Biometry; C-reactive protein; Career Transition Award; Case-Control Studies; Cause of Death; Child; Childhood; Communities; Complement; Complex; Critical Care; Critical Illness; Critically ill children; Data; Data Set; Development; Early Intervention; Early identification; Environment; Evaluation; Evolution; Family; Functional disorder; Future; Genetic Markers; Genetic Variation; Genotype; Growth and Development function; Health; Hospitals; Iatrogenesis; Immersion; Individual; Infection; Inflammation; Inflammation Mediators; Inflammatory; Intensive Care; Interleukin-6; Interleukin-8; Intervention; Knowledge; Longitudinal cohort study; Measures; Mentors; Mentorship; Mission; Modeling; Morbidity - disease rate; Muscular Atrophy; National Institute of Nursing Research; Nature; Nurses; Pediatric Hospitals; Pediatric Intensive Care Units; Pediatrics; Pennsylvania; Performance; Phase; Phenotype; Philadelphia; Physical Function; Positioning Attribute; Predictive Analytics; Quality of life; Randomized; Recovery; Rehabilitation therapy; Reporting; Research; Research Design; Research Personnel; Respiratory Failure; Risk; Role; Sampling; Scientist; Sedation procedure; Sepsis; Statistical Methods; Survivors; Syndrome; Techniques; Titrations; Training; Universities; Validation; Vulnerable Populations; Work; base; biobehavior; career; cohort; experience; follow-up; improved; meetings; model development; pediatric sepsis; pre-doctoral; programs; prospective; skills; symposium; symptom science

PROJECT SUMMARY/ABSTRACT Sepsis in children is a leading cause of death and morbidity, yet little is known about its impact on physical function after hospital discharge. Building upon the candidate’s prior biobehavioral research, this proposed K99/R00 application will utilize symptom science approaches to explore the potential role of pro-inflammatory mediators as they pertain to physical function in critically ill children who survive sepsis. This proposed application aligns well with the mission of the National Institute for Nursing Research, “to promote and improve the health and quality of life of individuals, families and communities.” The overall purpose of this K99/R00 application, Maximizing Opportunities for Scientific and Academic Independent Careers (MOSAIC) Postdoctoral Career Transition Award to Promote Diversity (PAR-19-343), is to prepare the candidate for an independent career as a nurse scientist with a robust program of research in pediatric critical care and symptom science. In the initial mentored phase (K99), the candidate will utilize existing data to (A1) develop PEdiatric Recovery after sepSIS Treatment in the Pediatric Intensive Care Unit (PERSIST-PICU), a multivariable model to identify risk physical dysfunction risk in critically ill children who survive sepsis. Sub aims include (A1.1) associating the critically ill child’s course of illness with physical function after PICU discharge; and (A1.2) associating the role of inflammation during critical illness on physical function after PICU discharge. The candidate will develop a model through advanced statistical methods to identify children who are a-risk for physical dysfunction after PICU discharge. In the independent phase (R00), the candidate will conduct a prospective longitudinal cohort study to (A2) refine PERSIST-PICU model with new biological measures of inflammation. Identification of critically ill children with sepsis who are at-risk for physical dysfunction after discharge will provide an opportunity for early intervention to optimize their physical function after critical illness. The mentored phase of this award (K99) will include training by a well-crafted, interprofessional team of scientists who are experts in the proposed study design and advanced biostatistical modeling of inflammatory biomarkers in pediatric critical care. In addition, the candidate has proposed an individualized training plan to meet her unique training needs. The training plan includes attendance at the MOSAIC UE5 educational conference, seminars, scientific meetings and targeted coursework. The candidate’s stellar mentorship team, tailored research plan and findings within this K99/R00 application will prepare her well for transition to independence as a nurse scientist in pediatric critical care and symptom science.

项目摘要/摘要 儿童败血症是死亡和发病率的主要原因 在候选人先前的生物行为研究上，霍斯皮塔尔的功能 K99/R00应用将利用症状科学方法来探讨亲炎的潜在作用 介体与生存败血症的重症儿童有关的身体机能。 应用程序与美国国家护理研究所的使命非常吻合，“促进和改进 个人，家庭和社区的健康和生活质量。 应用，最大化科学和学术独立职业的机会（Mosaic） 博士后职业过渡奖促进多样性（Par-19-343），是为候选人做好准备的 独立职业作为护士科学家，具有强大的研究计划 症状科学在初始指导阶段（K99），候选人将使用现有数据 小儿重症监护病房（Persist-PICU）的败血症治疗后的小儿恢复， 多变量模型，以确定在败血症中生存的重症儿童中风险的身体发挥功能障碍风险。 包括（A1.1）将Critisty Illy的病程与PICU DISCALE之后的身体机能相关联； （A1.2）将炎症在危重疾病中的作用关联在PICU出院后的身体机能中。 候选人将通过高级统计方法开发模型，以识别A风险的儿童 PICU放电后的物理功能障碍。 前瞻性纵向队列研究（A2）改进Persone Persone Persone Persone人，具有新的生物学测量 炎症。 出院将主要是早期干预的机会，以在关键之后优化其身体功能 疾病。 科学家是炎症的支撑研究设计和高级生物统计模型的专家 生物标志物 满足她独特的培训需求。 会议，研讨会，科学会议和针对性的课程。 在此K99/R00应用程序中量身定制的研究计划和调查结果将使她的良好福利为公平做好准备 作为儿科重症监护和症状科学的护士科学家的独立性。