Core C: Translational Neurosciences Core

核心 C：转化神经科学核心

• 批准号: 10686030
• 负责人: Laurie E Cutting
• 金额: $ 20.93万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-06 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10686030
• 关键词: Academic Medical Centers; Address; Affect; Algorithms; Area; Behavioral; Big Data; Biological Markers; Caregivers; Categories; Child; Clinical; Communities; Data; Data Analyses; Data Collection; Data Set; Databases; Development; Discipline; Disease; Down Syndrome; Education; Electroencephalography; Ensure; Event-Related Potentials; Experimental Designs; Faculty; Funding; Goals; High Performance Computing; Human; Image; Individual; Infant; Intellectual Interest; Intellectual and Developmental Disabilities Research Centers; Intellectual functioning disability; Machine Learning; Magnetic Resonance; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Measures; Methods; Mission; Modality; Morphologic artifacts; Motion; Movement; Persons; Population; Prevention; Productivity; Protocols documentation; Psychophysiology; Research; Research Design; Research Personnel; Resources; Scanning; Science; Scientist; Services; Site; Source; Special Population; Technical Expertise; Techniques; Testing; Translations; Universities; Work; analysis pipeline; autism spectrum disorder; big-data science; cluster computing; cost effective; cost efficient; data acquisition; data de-identification; data management; data repository; design; disability; image processing; imaging capabilities; improved; individualized medicine; innovation; interdisciplinary collaboration; member; mouse model; neural; neuroimaging; neurophysiology; novel; programs; public health relevance; repository; targeted treatment; tool; translational neuroscience; visual tracking

The Translational Neuroscience Core will: 1) provide IDDRC investigators with facilities and services to support their individual human neuroimaging and psychophysiological research programs in the area of intellectual and developmental disabilities (IDD); 2) continue to develop trans-species methods for acquiring neuroimaging and psychophysiological measures in humans with IDD and IDD mouse models; 3) utilize repositories of ‘big data’ at Vanderbilt to develop new tools and discoveries for IDD; 4) facilitate interdisciplinary collaborations among IDDRC investigators who may or may not have neuroimaging expertise; and 5) ensure that the services provided are timely, highest quality, and cost-effective. The Translational Neuroscience Core C will support P50 users in the above areas for magnetic resonance (MR) neuroimaging as well as psychophysiological measures. The Core’s services can be broadly construed into two different categories: (1) those that are responsive to investigators’ needs and (2) those that are generative, and provide new directions in IDD for investigators to leverage. Investigator need-based services provided include assistance in (a) experimental design, including selecting appropriate tasks for magnetic resonance imaging (MRI) or electroencephalogram (EEG)/event-related potentials (ERP), (b) identification of the optimal modalities of MR imaging or EEG/ERP/eye tracking acquisition parameters (c) implementation of MRI and EEG/ERP data collection with special populations (individuals with various IDDs, especially infants and children), and (d) management and analysis of MRI and EEG/ERP/eye tracking data. The generative and innovative component of the Translational Neuroscience Core C focuses on key areas that are of particular interest for IDD researchers: design of novel experimental paradigms optimized for IDDs, expanding trans-species imaging capabilities, implementing and augmenting novel data acquisition and analysis methods for measuring neural biomarkers of IDD, developing robust image processing techniques to handle challenging data (e.g., movement artifacts), and providing tools to enable optimal establishment, usage, and analysis of ‘big data’ repositories such as ImageVU. While expertise and resources in neuroimaging, advanced computing, and data management tools are available at Vanderbilt University, none are tailored for the special needs of those who study IDDs. The Aims and services in Core C all have the central goal: facilitate cost-efficient discovery that leads to the prevention and/or amelioration of IDD. Each member of the Core has strong ties to the larger Vanderbilt community, thus enabling seamless linkages between entities at Vanderbilt that are critical for the Core. The Core will serve 22 funded IDD research-related projects.

翻译神经科学核心将：1）为IDDRC调查人员提供支持的设施和服务 他们的个人人类神经影像学和心理生理研究计划 发育障碍（IDD）； 2）继续开发跨物种方法来获得神经成像和 人类具有IDD和IDD小鼠模型的心理生理措施； 3）利用“大数据”的存储库 在范德比尔特（Vanderbilt）为IDD开发新的工具和发现； 4）促进跨学科合作 IDDRC调查人员可能具有或没有神经影像学专业知识； 5）确保服务 提供的是及时，质量最高且具有成本效益的。翻译神经科学核心C将支持 上述磁共振（MR）神经影像和心理生理的P50用户 措施。核心的服务可以广泛地构建为两个不同类别：（1） 响应调查人员的需求和（2）通用的需求，并在IDD中提供新的方向 供研究人员利用。提供的基于研究者的服务提供了（a）实验中的帮助 设计，包括选择用于磁共振成像（MRI）或脑电图的合适任务 （EEG）/与事件相关电位（ERP），（b）识别MR成像或 EEG/EEG/ERP/眼睛跟踪采集参数（C）MRI和EEG/ERP数据收集的实现 特殊人群（具有不同IDD的人，尤其是婴儿和儿童），以及（d）管理和 MRI和EEG/ERP/眼动数据的分析。的通用和创新成分 转化神经科学核心C的重点是IDD研究人员特别感兴趣的关键领域： 针对IDD优化的新型实验范式的设计，扩展了反式物种成像功能， 实施和增强新的数据获取和分析方法，用于测量神经生物标志物 IDD，开发强大的图像处理技术来处理挑战数据（例如，运动伪像）， 并提供工具来实现“大数据”存储库的最佳建立，使用和分析 Imagevu。而神经影像，高级计算和数据管理工具的专业知识和资源 可在范德比尔特大学（Vanderbilt University）购买，没有一个针对学习IDD的人的特殊需求量身定制的。 核心C中的目标和服务都有一个中心目标：最喜欢的成本效益发现，导致了 IDD的预防和/或改善。核心的每个成员都与较大的范德比尔特有密切的联系 社区，从而使范德比尔特实体之间的无缝联系对核心至关重要。 Core将为22个资助IDD研究相关的项目提供服务。