Core C: Translational Neurosciences Core

核心 C：转化神经科学核心

• 批准号: 10415085
• 负责人: Laurie E Cutting
• 金额: $ 20.93万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-06 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10415085
• 关键词: Academic Medical Centers; Address; Affect; Algorithms; Area; Behavioral; Big Data; Biological Markers; Caregivers; Categories; Child; Clinical; Communities; Data; Data Analyses; Data Collection; Data Set; Databases; Development; Discipline; Disease; Down Syndrome; Education; Electroencephalogram; Ensure; Event-Related Potentials; Experimental Designs; Faculty; Funding; Goals; High Performance Computing; Human; Image; Individual; Infant; Institutes; Intellectual Interest; Intellectual and Developmental Disabilities Research Centers; Intellectual functioning disability; Lead; Machine Learning; Magnetic Resonance; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Measures; Methods; Mission; Modality; Morphologic artifacts; Motion; Movement; Persons; Population; Prevention; Protocols documentation; Psychophysiology; Research; Research Design; Research Personnel; Resources; Scanning; Science; Scientist; Services; Site; Source; Special Population; Technical Expertise; Techniques; Testing; Time; Translations; Universities; Work; analysis pipeline; autism spectrum disorder; base; big-data science; cluster computing; cost effective; cost efficient; data acquisition; data de-identification; data management; data pipeline; data repository; design; disability; image processing; imaging capabilities; improved; individualized medicine; innovation; interdisciplinary collaboration; member; mouse model; neuroimaging; neurophysiology; novel; programs; public health relevance; relating to nervous system; repository; targeted treatment; tool; translational neuroscience; visual tracking

The Translational Neuroscience Core will: 1) provide IDDRC investigators with facilities and services to support their individual human neuroimaging and psychophysiological research programs in the area of intellectual and developmental disabilities (IDD); 2) continue to develop trans-species methods for acquiring neuroimaging and psychophysiological measures in humans with IDD and IDD mouse models; 3) utilize repositories of ‘big data’ at Vanderbilt to develop new tools and discoveries for IDD; 4) facilitate interdisciplinary collaborations among IDDRC investigators who may or may not have neuroimaging expertise; and 5) ensure that the services provided are timely, highest quality, and cost-effective. The Translational Neuroscience Core C will support P50 users in the above areas for magnetic resonance (MR) neuroimaging as well as psychophysiological measures. The Core’s services can be broadly construed into two different categories: (1) those that are responsive to investigators’ needs and (2) those that are generative, and provide new directions in IDD for investigators to leverage. Investigator need-based services provided include assistance in (a) experimental design, including selecting appropriate tasks for magnetic resonance imaging (MRI) or electroencephalogram (EEG)/event-related potentials (ERP), (b) identification of the optimal modalities of MR imaging or EEG/ERP/eye tracking acquisition parameters (c) implementation of MRI and EEG/ERP data collection with special populations (individuals with various IDDs, especially infants and children), and (d) management and analysis of MRI and EEG/ERP/eye tracking data. The generative and innovative component of the Translational Neuroscience Core C focuses on key areas that are of particular interest for IDD researchers: design of novel experimental paradigms optimized for IDDs, expanding trans-species imaging capabilities, implementing and augmenting novel data acquisition and analysis methods for measuring neural biomarkers of IDD, developing robust image processing techniques to handle challenging data (e.g., movement artifacts), and providing tools to enable optimal establishment, usage, and analysis of ‘big data’ repositories such as ImageVU. While expertise and resources in neuroimaging, advanced computing, and data management tools are available at Vanderbilt University, none are tailored for the special needs of those who study IDDs. The Aims and services in Core C all have the central goal: facilitate cost-efficient discovery that leads to the prevention and/or amelioration of IDD. Each member of the Core has strong ties to the larger Vanderbilt community, thus enabling seamless linkages between entities at Vanderbilt that are critical for the Core. The Core will serve 22 funded IDD research-related projects.

转化神经科学核心将： 1) 为 IDDRC 研究人员提供设施和服务以支持 他们在智力和智力领域的个人人类神经影像和心理生理学研究项目 发育障碍（IDD）；2）继续开发获取神经影像的跨物种方法 3）利用“大数据”存储库对患有 IDD 的人类和 IDD 小鼠模型进行心理生理测量； 在范德比尔特开发 IDD 的新工具和发现 4) 促进跨学科合作； IDDRC 调查员可能具有或不具有神经影像学专业知识，并且 5) 确保提供服务； 转化神经科学核心 C 将提供及时、最高质量和成本效益的支持。 上述领域的 P50 用户用于磁共振 (MR) 神经影像以及心理生理学 核心的服务可大致分为两类：(1) 那些 响应研究者的需求和 (2) 具有创造性的需求，并为 IDD 提供新的方向 供研究者利用的基于需求的服务包括 (a) 实验方面的帮助。 设计，包括选择适当的磁共振成像（MRI）或脑电图任务 (EEG)/事件相关电位 (ERP)，(b) 确定 MR 成像的最佳方式或 EEG/ERP/眼动追踪采集参数 (c) 实施 MRI 和 EEG/ERP 数据采集 特殊人群（患有各种 IDD 的个人，特别是婴儿和儿童），以及 (d) 管理和 MRI 和 EEG/ERP/眼动追踪数据的分析。 转化神经科学核心 C 重点关注 IDD 研究人员特别感兴趣的关键领域： 设计针对 IDD 优化的新颖实验范例，扩展跨物种成像能力， 实施和增强用于测量神经生物标志物的新型数据采集和分析方法 IDD，开发强大的图像处理技术来处理具有挑战性的数据（例如，运动伪影）， 并提供工具以实现“大数据”存储库的最佳建立、使用和分析，例如 ImageVU。虽然神经影像、高级计算和数据管理工具方面的专业知识和资源 范德比尔特大学提供了这些课程，但没有一个是针对学习 IDD 的人的特殊需求而量身定制的。 Core C 中的目标和服务都有一个中心目标：促进经济高效的发现，从而实现 预防和/或改善 IDD 的每个核心成员都与更大的范德比尔特大学有着密切的联系。 社区，从而实现对核心至关重要的范德比尔特实体之间的无缝联系。 Core 将为 22 个受资助的 IDD 研究相关项目提供服务。