Developmental Research Program

发展研究计划

• 批准号: 8738876
• 负责人: JAMES A FAGIN
• 金额: $ 6.36万
• 依托单位: SLOAN-KETTERING INST CAN RESEARCH
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-19 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8738876
• 关键词: Advisory Committees; Advocate; Budgets; Clinical; Committee Members; Communities; Consultations; Data; Development; Diagnosis; Disease; Etiology; Fostering; Funding; Generations; Goals; Grant; Hospitals; Incidence; Investigator-Initiated Research; Leadership; Malignant neoplasm of thyroid; Medicine; Memorial Sloan-Kettering Cancer Center; New York; Patients; Peer Review; Physicians; Pilot Projects; Play; Presbyterian Church; Prevention; Process; Public Health; Qualifying; Relative (related person); Research; Research Personnel; Research Project Grants; Resources; Role; SKI gene; Seeds; Thyroid Gland; Translational Research; Universities; Voting; anticancer research; base; cancer diagnosis; cancer prevention; cancer therapy; college; high risk; innovation; medical schools; meetings; programs

Translational research into thyroid cancer is underdeveloped relative to its growing incidence, impact on public health and to the scientific opportunities that could be exploited. The Developmental Research Program will play an_essential role in fostering research into the disease. We will use DRP funding supplemented by a strong commitment of institutional funds to support innovative projects by new and established investigators, which are critical to the generation of new ideas in thyroid cancer diagnosis and treatment. Our goal is to establish mechanisms for rapid funding of important new directions to accelerate progress towards the translational research goals of our SPORE. We identified a credible portfolio of promising developmental research projects, which will be competing for support once the program is established. We will request thyroid pilot project proposals with translational potential from clinical and basic investigators within the larger MSKCC community, including Rockefeller University, New York-Presbyterian Hospital, Weill Medical College of Cornell University, as well as from the Albert Einstein College of Medicine. We will then select the most promising new projects for support after rigorous peer review by the Executive Committee, the Internal Advisory Committee and the Patient Advocates. The opinion of external reviewers will be solicited as needed. Pilot projects will be funded for 1 year, but investigators may apply for additional funding through this same competitive process the next year. Every year the Internal Advisory Committee and the Executive Committee members meet to review each research project, core and developmental pilot project. Committee members will be asked to assess whether any developmental project has progressed sufficiently and shown enough translational potential so as to eclipse that of one ofthe full research projects. The committee members will then vote and decide whether any developmental project should be advanced to full research status. If so, the budgets will be appropriately adjusted, and sent for final approval to the Physician-in-Chief and the Director of the SKI, after consultation with the TRP of the NCI.

相对于其不断增长的发病率和对甲状腺癌的影响，甲状腺癌的转化研究尚不发达。 公共卫生和可以利用的科学机会。发展研究 该计划将在促进对该疾病的研究方面发挥重要作用。我们将使用 DRP 资金 辅之以机构资金的坚定承诺，以支持新的和 已建立的研究人员，这对于甲状腺癌诊断和治疗新想法的产生至关重要 治疗。我们的目标是建立快速资助重要新方向的机制，以加速 我们的 SPORE 转化研究目标取得了进展。我们确定了可靠的投资组合 有前途的发展研究项目，一旦该项目启动，这些项目将竞争支持 已确立的。我们将请求具有临床和基础转化潜力的甲状腺试点项目提案 更大的 MSKCC 社区内的研究人员，包括洛克菲勒大学、纽约长老会医院 医院、康奈尔大学威尔医学院以及阿尔伯特·爱因斯坦医学院。 经过执行官严格的同行评审后，我们将选择最有前途的新项目进行支持 委员会、内部咨询委员会和患者权益倡导者。外部评审员的意见 将根据需要进行征集。试点项目将获得为期一年的资助，但研究人员可以申请额外的资助 明年通过同样的竞争过程提供资金。每年内部顾问委员会 执行委员会成员开会审查每个研究项目、核心和发展试点 项目。委员会成员将被要求评估是否有任何开发项目取得进展 充分并显示出足够的转化潜力，以至于使一项完整的研究项目黯然失色。 然后，委员会成员将投票决定是否应该推进任何开发项目 至全面研究状态。如果是这样，预算将适当调整，并报请最终批准。 与 NCI 的 TRP 协商后，由主治医师和 SKI 主任决定。