Center for 3D Imaging in Cancer Cell Biology

癌细胞生物学 3D 成像中心

• 批准号: 10375191
• 负责人: Denis Wirtz
• 金额: $ 4.67万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-12-01 至 2026-11-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10375191
• 关键词: 3-Dimensional; Address; Administrative Coordination; Advisory Committees; Advocate; Architecture; Basic Science; Beds; Biomedical Research; Budgets; Cancer Biology; Cells; Cellular biology; Chemicals; Collaborations; Communication; Communities; Comprehensive Cancer Center; Computing Methodologies; Disease; Doctor of Medicine; Doctor of Philosophy; Documentation; Engineering; Ensure; Event; Faculty; Financial Support; Funding; Gene Expression; Goals; Human; Human Resources; Imaging technology; Individual; Infrastructure; Institutes; Institutional Review Boards; Lead; Leadership; Liver; Malignant Neoplasms; Mentors; Mission; Monitor; Occupational activity of managing finances; Oncology; Pancreas; Pathology; Patient-Focused Outcomes; Patients; Productivity; Progress Reports; Publications; Reporting; Research; Research Personnel; Role; Schedule; Schools; Strategic Planning; Testing; Three-Dimensional Imaging; Three-dimensional analysis; Time; TimeLine; Tissues; United States National Institutes of Health; Wood material; anticancer research; biophysical properties; cancer cell; cancer imaging; career; clinically relevant; experience; imaging modality; improved; innovation; materials science; medical schools; meetings; member; mid-career faculty; multidisciplinary; nanobiotechnology; next generation; outreach; pancreatic cancer cells; pre-clinical research; professor; skills; success; synergism; technology development; tumor; web site

Administration and Coordination Core - Project Summary: The Johns Hopkins Center for 3D Multiscale Cancer Imaging will facilitate innovation in advanced imaging technologies that could be applied to fundamental basic and pre-clinical research problems in cancer biology. The mission of our Administrative and Coordination (A&C) Core is to ensure that the individual Research Units combine with synergy beyond the individual parts, to contribute to the CCBIR Network with strength beyond the individual Center, to integrate with the NCI and the cancer research community, and to be a partner with patient advocates to connect basic research with improved patient outcomes. The Center brings together preeminent faculty from eight departments housed in two schools (Medicine and Engineering), three JHU Centers and Institutes, and a spatial omic expert at Yale. This multidisciplinary perspective enables us to bring the latest experimental and computational methods to bear on the most clinically relevant aspects of cancer. Center leadership are tremendously excited about the impact of the proposed Center and this is evident in substantial technical, administrative, and financial support provided to our team through scientific cores, administrative support from the Provost's office and Dean's office, and over $1M in matching funds. The leadership of the Center is strongly committed to mentoring the next generation of leaders in cancer research including those traditionally underrepresented in biomedical research. Our JH Center includes two early-stage investigators (ESI) as critical co-Leads of the first Technology Development Unit (Dr. Ho and Dr. Wu). Our Administrative Core will ensure the successful execution of our ambitious mission directed by two aims. Aim 1: Scientific and Financial Management of the Center. Drs. Wirtz and Wood will have overall responsibility for the scientific and administrative leadership of the Center, with support from an experienced Project Manager. A Steering Committee including the Multiple PIs, the Unit Leads and co-Leads, and the Project Manager will meet monthly to discuss scientific progress, challenges, and budgetary issues. The A&C Core will refine and monitor budgets, allocating funds to each unit to achieve overall center goals. They will also take the lead on preparing timely reports to the NIH, the Hopkins IRB, and other oversight regulatory bodies. Aim 2: Communication and Review: External Advisory Panel (EAP), Internal Advisory Committee (IAC), Patient Advocates, and NCI. The Core will develop and ensure timely communications and documentation within the Center and across all Centers within the network. In addition, the Core will monitor timelines and milestones, and assign tasks to the unit leaders to assure that milestones are met. Oversight will be provided by an EAP and the NCI. The A&C will gather annual progress reports from the units, address any potential major changes in direction, and with patient advocates, guide how our research relates to patient needs. The Center progress will be tracked using standard metrics in place for large projects at Hopkins, covering four domains (staffing, fiscal, productivity, and infrastructure).

行政和协调核心 - 项目摘要： 约翰·霍普金斯大学 3D 多尺度癌症成像中心将促进先进成像领域的创新 可应用于癌症生物学的基础和临床前研究问题的技术。 我们的行政和协调 (A&C) 核心的使命是确保各个研究单位 与各个部分之外的协同作用相结合，以超越各个部分的力量为 CCBIR 网络做出贡献 独立中心，与 NCI 和癌症研究界整合，成为患者的合作伙伴 倡导将基础研究与改善患者治疗结果联系起来。该中心汇集了优秀的 来自两所学校（医学和工程）、三个 JHU 中心和 8 个系的教师 研究所和耶鲁大学的空间组学专家。这种多学科视角使我们能够带来最新的 实验和计算方法与癌症最临床相关的方面有关。中心 领导层对拟议中心的影响感到非常兴奋，这一点在实质性 通过科学核心、行政管理为我们的团队提供技术、行政和财务支持 来自教务长办公室和院长办公室的支持，以及超过 100 万美元的配套资金。的领导 中心坚定致力于指导下一代癌症研究领导者，包括那些 传统上在生物医学研究中代表性不足。我们的 JH 中心包括两名早期研究人员 (ESI) 作为第一个技术开发部门的关键联合领导者（何博士和吴博士）。我们的行政核心 将确保我们成功执行由两个目标引导的雄心勃勃的使命。目标 1：科学和金融 中心的管理。博士。维尔茨和伍德将全面负责科学和 中心的行政领导，并得到经验丰富的项目经理的支持。一个转向 由多个 PI、单位领导和联合领导以及项目经理组成的委员会将每月举行一次会议 讨论科学进步、挑战和预算问题。 A&C 核心将完善和监控预算， 向各单位分配资金，以实现中心的总体目标。他们也会带头及时做好准备 向 NIH、霍普金斯 IRB 和其他监督监管机构报告。目标 2：沟通和审查： 外部咨询小组 (EAP)、内部咨询委员会 (IAC)、患者权益倡导者和 NCI。核心将 制定并确保中心内部以及内部所有中心之间的及时沟通和文件记录 网络。此外，核心将监控时间表和里程碑，并向单位领导分配任务 确保达到里程碑。 EAP 和 NCI 将提供监督。 A&C将每年一度 各单位的进度报告，解决方向上任何潜在的重大变化，并与患者倡导者一起， 指导我们的研究如何与患者需求相关。中心的进展将使用标准指标进行跟踪 霍普金斯大学大型项目的场所，涵盖四个领域（人员、财务、生产力和基础设施）。