Neurobehavioral Evaluation Core

神经行为评估核心

基本信息

批准号：
10686092
负责人：
Madison Mehalani Berl
金额：
$ 20万
依托单位：
CHILDREN'S RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-21 至 2026-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10686092
关键词：
Adult Anatomy Animal Behavior Animal Model Animals Anxiety Assessment tool Attention Behavior Behavior assessment Behavioral Behavioral Assay Bioinformatics Biological Biometry Birth Brain Brain Diseases Cells Child Circadian Rhythms Clinical Research Clinical Trials Cognition Cognitive Collaborations Collection Communities Complement Complex Computer software Data Storage and Retrieval Database Management Systems Development Diagnosis Disease District of Columbia Doctor of Philosophy Epilepsy Evaluation Face Fetal Alcohol Syndrome Fiber Fostering Functional Magnetic Resonance Imaging Functional disorder Genes Genetic Genomics Genotype Goals Human Human Resources Hypoxia Image Individual Intellectual and Developmental Disabilities Research Centers International Intervention Intervention Studies Investigation Knowledge Language Learning Link Measures Memory Methods Microscopy Mission Modeling Molecular Monitor Moods Motor Motor Activity Mus Myelin Neonatal Brain Injury Neurobiology Neurodevelopmental Disorder Neurons Neuropsychology Neurosciences Outcome Phenotype Photometry Physiological Play Prevention Protocols documentation Publications Quality Control Reproducibility Research Personnel Resources Role Sensory Study models System Technology Testing Therapeutic Tissues Training Translating Treatment Efficacy Vision Visuospatial animal imaging autism spectrum disorder awake behavior test bench to bedside catalyst clinical translation cognitive function comorbidity cost effective data reduction deep learning digital efficacy evaluation emotional functioning executive function fetal gene therapy human imaging human model in vivo in vivo monitoring innovation multiphoton imaging neural circuit neural correlate neurobehavior neurobehavioral neurobiological mechanism novel optogenetics pharmacologic porcine model pre-clinical preclinical study social social communication success symposium tool translational approach translational potential

项目摘要

Abstract The mission of the Neurobehavioral Evaluation Core (NEC) is to provide District of Columbia Intellectual and Developmental Disabilities Research Center (DC-IDDRC) investigators with resources to link underlying biological mechanisms of neurodevelopmental disorders with behavioral and cognitive outcomes as measured in humans and animal models. DC-IDDRC investigators have access to state-of-the-art neurobehavioral assessment tools in humans and cognate animal models to integrate preclinical and clinical studies with genetic and neurobiological analysis of abnormalities associated with IDDs. The NEC enhances efficiency by providing access to expert personnel and testing tools not available to individual labs or investigators. The NEC is comprised of two complementary subcores; the Human Neurobehavior Core (HNEC), directed by Madison Berl, PhD and the Animal Neurobehavior Core (ANEC) directed by Joshua Corbin, PhD. The primary objectives of the NEC are to provide: (a) overall vision, planning, training and implementation of human behavioral tasks and complementary behavioral assessments in cognate animal models of human neurodevelopmental disorders, (b) to develop, maintain and implement state of the art platforms and resources for human and animal neurobehavior investigation and across multiple animal models, (c) to collaborate and integrate with all DC-IDDRC cores to unravel neurobiological mechanisms from genes to circuits to behaviors underlying a host of IDDs, (d) to facilitate the conduct of robust, reproducible and rigorous scientific investigation with a high impact on the field of neuroscience and IDDs, (e) to disseminate findings broadly to the scientific and academic communities via publications, presentations and international conference forums, (f) to use the knowledge gained from human and animal behavior assessments to test and translate findings from the bench to the bedside. These goals will be achieved in the following specific aims: (1) To define the consequences of IDDs on human neurobehavior and animal behavioral correlates, (2) To expand and implement the use state-of-the-art technologies for human and animal behavior assessment and (3) To develop/identify longitudinal assessment paradigms that are sensitive to change in IDDs in humans and animal models and that will be critical for monitoring success of intervention studies. The NEC has long standing strengths in the analysis of humans and animal models of a number of neurodevelopmental disorders including autism spectrum disorders, epilepsy, fetal alcohol syndrome and fetal/neonatal brain injury. Over the past years, our highly successful animal model studies have elucidated cellular and molecular mechanisms underlying physiological and behavioral abnormalities in these prevalent conditions, while our human investigation has linked atypical trajectories of brain development to their structural and behavioral correlates. Building on these strengths, our increasing variety and sophisticated human and animal behavioral assessment platforms will also be widely applicable across a host of neurodevelopmental conditions.

抽象的神经行为评估核心（NEC）的使命是为哥伦比亚特区提供知识分裂和发育障碍研究中心（DC-IDDRC）研究人员，资源可以联系起来具有行为和认知结果的神经发育障碍的生物学机制，如所测量在人类和动物模型中。 DC-IDDRC调查人员可以使用最新的神经行为人类和同类动物模型的评估工具，将临床前和临床研究整合到与IDD相关的异常的遗传和神经生物学分析。 NEC通过提供对个人实验室或调查人员无法获得的专家人员和测试工具的访问权限。这 NEC由两个互补子核组成。人类神经行为核心（HNEC），由麦迪逊·贝尔（Madison Berl）博士和由约书亚·科宾（Joshua Corbin）博士执导的动物神经行为核心（ANEC）。主要 NEC的目标是提供：（a）人类的整体愿景，计划，培训和实施人类的同源动物模型中的行为任务和互补行为评估神经发育障碍，（b）开发，维护和实施最艺术平台和资源的状态用于人类和动物神经行为研究以及在多种动物模型中进行协作和与所有DC-IDDRC核心整合到从基因到电路到行为的神经生物学机制（d）的基本IDD的基础，以促进稳健，可重复和严格的科学的行为对神经科学和IDD领域产生高影响的调查，（e）广泛地传播发现通过出版物，演讲和国际会议论坛的科学和学术社区，（f）利用从人类和动物行为评估中获得的知识来测试和翻译发现从长凳到床边。这些目标将在以下特定目标中实现：（1）定义 IDD对人神经行为和动物行为的后果与（2）扩展和对人类和动物行为评估实施最先进的技术，以及（3）开发/识别对人类IDD敏感的纵向评估范例和动物模型，这对于监测干预研究的成功至关重要。 NEC有在分析人类和许多神经发育的动物模型中长期存在的优势包括自闭症谱系障碍，癫痫，胎儿酒精综合征和胎儿/新生儿脑损伤的疾病。在过去的几年中，我们非常成功的动物模型研究阐明了细胞和分子在这些普遍条件下生理和行为异常的机制，而我们人类调查已将大脑发育的非典型轨迹与它们的结构和行为联系起来相关。在这些优势的基础上，我们不断增长的多样性和成熟的人类和动物行为评估平台还将广泛适用于许多神经发育条件。