Cognitive Impairment Moderated by Working Memory in Pediatric Partial Epilepsy

小儿部分性癫痫中工作记忆调节的认知障碍

• 批准号: 8231542
• 负责人: Madison Mehalani Berl
• 金额: $ 16.5万
• 依托单位: CHILDREN'S RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8231542
• 关键词: Address; Age; Area; Back; Base of the Brain; Behavioral; Benchmarking; Biological Neural Networks; Biometry; Brain region; Child; Childhood; Clinical; Clinical Research; Cognitive; Cognitive deficits; Color; Commit; Comorbidity; Complex; Cross-Sectional Studies; Development; Diffusion; Emotional; Epilepsy; Fiber; Future; Gender; Impaired cognition; Impairment; Inferior frontal gyrus; Intervention; Language; Lead; Left; Link; Magnetic Resonance Imaging; Measures; Memory; Memory impairment; Mentors; Methodology; Methods; Middle frontal gyrus structure; Mind; Modeling; Nature; Neuroanatomy; Neurobiology; Neurodevelopmental Disorder; Neurologist; Neurophysiology - biologic function; Neuropsychological Tests; Neuropsychology; Neurosciences; Partial Epilepsies; Performance; Predisposition; Process; Recruitment Activity; Research Design; Seizures; Short-Term Memory; Structure; System; Task Performances; Techniques; Testing; Training; United States National Institutes of Health; base; behavioral impairment; career; cognitive neuroscience; executive function; experience; innovation; language processing; neurobehavioral; neuroimaging; neuropsychological; performance tests; public health relevance; skills; social; white matter

DESCRIPTION (provided by applicant): The candidate's application provides the requisite training to establish a clinical research career committed to identify the susceptibility factors in the cognitive comorbidity of epilepsy which is in line with NIH Curing Epilepsy Benchmarks. The candidate is a clinical pediatric neuropsychologist who is proposing to obtain cross-disciplinary training from a neurologist lead co-mentor, neuropsychologist lead co-mentor and distinguished panel of expert mentors and contributors in advanced MRI techniques, developmental cognitive neuroscience, neuropsychology, and biostatistics. This is a cross-sectional study of 50 children with localization related epilepsy who will be matched to healthy controls for age, gender, and SES. Sophisticated neuroscience methods will be used to investigate the functional and structural neuroanatomy of verbal working memory. Working memory, language, and other cognitive domains will be examined by conducting neuropsychological testing, and then all children will participate in functional and structural neuroimaging tasks. It is hypothesized that children with epilepsy will have specific weaknesses in working memory and show greater deviance in the structure and function of brain regions activated. These results will be crucial for developing an informed model of specific brain based cognitive impairments to base and measure future treatments against. This training will enable the candidate to obtain unique cross-disciplinary training using integrated neuroimaging and neuropsychology methods. The candidate will also be well-situated to transition this methodology into other neurodevelopmental disorders over the duration of her career. PUBLIC HEALTH RELEVANCE: Children with epilepsy often experience behavioral and cognitive difficulties. One area of difficulty is executive functioning which is a set of skills important for efficient task performance. This study characterizes the neural network of one aspect of executive functioning, namely working memory, in children with epilepsy using neuroimaging and neuropsychological measures.

描述（由申请人提供）：候选人的申请提供了必要的培训，以建立致力于确定癫痫认知合并症的易感因素的临床研究职业，该癫痫的合并症与NIH治疗癫痫基准相符。候选人是一名临床小儿神经心理学家，他提议从神经科学家领导者，神经心理学家负责人领导者和杰出的专家小组培训中获得跨学科的培训，以及高级MRI技术，发展性认知神经科学，神经心理学和生物统计学的高级MRI技术和贡献者。这是对50名与定位相关癫痫病的儿童的横断面研究，他们将与年龄，性别和SES的健康对照相匹配。复杂的神经科学方法将用于研究言语工作记忆的功能和结构性神经解剖学。工作记忆，语言和其他认知领域将通过进行神经心理学测试来检查，然后所有儿童将参加功能和结构性神经影像学任务。假设患有癫痫病的儿童在工作记忆中会有特定的弱点，并在激活的大脑区域的结构和功能上显示出更大的偏差。这些结果对于开发特定的基于大脑的认知障碍的知情模型至关重要，以基础并衡量未来的治疗方法。该培训将使候选人能够使用综合神经影像学和神经心理学方法获得独特的跨学科培训。在她的职业生涯中，候选人还将有充分的态度将这种方法转变为其他神经发育障碍。 公共卫生相关性：癫痫患者经常遇到行为和认知困难。一个困难的领域是执行功能，这是一组对于高效任务绩效重要的技能。这项研究表征了使用神经影像学和神经心理学措施的癫痫患者，执行功能的一个方面的神经网络，即工作记忆。