UCLA IDDRC: Translational Core

加州大学洛杉矶分校 IDDRC：转化核心

• 批准号: 10686869
• 负责人: JAMES T. MCCRACKEN
• 金额: $ 19.16万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10686869
• 关键词: Address; Basic Science; Behavioral; Biological Specimen Banks; Biology; Child; Clinical; Clinical Investigator; Clinical Research; Clinical Trials; Cognitive; Competence; Consultations; Cost efficiency; Development; Diagnosis; Diagnostic; Evaluation; Fostering; Individual; Intellectual and Developmental Disabilities Research Centers; Intellectual functioning disability; Intervention Trial; Knowledge; Longevity; Longitudinal Studies; Machine Learning; Maintenance; Measurement; Measures; Methodology; Methods; Mission; Motor; Neurologic; Patients; Phenotype; Prevention; Procedures; Quality Control; Registries; Research; Research Design; Research Personnel; Risk; Scientific Advances and Accomplishments; Site; Sleep; Time; Training; Translational Research; career; clinical investigation; clinical phenotype; clinical research site; clinical translation; cost; data management; innovation; instrument; interest; minimally verbal; multidisciplinary; novel; outreach; recruit; response; social; theories; tool; translational goal

Clinical Translational Core: Abstract The mission of the Translational Clinical Core of the UCLA IDDRC, established in 2015, is to support high quality, multidisciplinary, collaborative clinical translational research advancing knowledge of causes, prevention, diagnosis, and treatment of intellectual and developmental disabilities (IDDs). To accomplish this, the Core will provide research consultation; access to reduced cost, specialized, research quality diagnostic and phenotypic assessments; recruitment support; training; data management; and other aids for IDDRC investigators bridging clinical research with basic science. The Core is engaged in advancing assessment methods for IDD research through innovative measure development, evaluation, and dissemination. The Core also supports outreach, biospecimen banking, and data management. In addition, the Core will participate in IDDRC Network and other IDDRC-related multi-site clinical investigations. Over the past 4 years, the Core has successfully established effective procedures for support of ongoing and new clinical IDD studies, nearly doubling the number supported during that timeframe, and has contributed new phenotyping measurements to the field. The Core has been impactful in supporting several new studies by early career investigators new to clinical studies. In this renewal, we are strengthening the Core by adding two new Core Co-Investigators (Drs. Catherine Lord and Rujuta Bhatt Wilson) who bring special expertise in social, diagnostic, behavioral, motor, and neurological assessments, IDD intervention trials, longitudinal studies, and large-scale training on gold standard diagnostic instruments. Core support is leveraged to achieve substantial cost efficiency, reducing individual project costs and by removing burdens of training, quality control, and maintenance of reliability from individual studies. Core access then enables expansion of research efforts and enhances quality of UCLA IDDRC research by establishing uniformity in diagnosis, phenotyping, and conduct of clinical studies. Measurement development efforts, utilizing sophisticated analytics such as Item Response Theory and machine learning, are aimed at addressing methodologic gaps that have plagued prior clinical research efforts relating to IDDs, and foster new research by providing tools better suited to capturing clinical manifestations of underlying biology, hence advancing clinical translation. Our training aims to build capacity for IDD research. Our team is especially well suited for advancing assessment approaches for use in minimally verbal individuals, and very young children at risk for IDDs, a strength of our team. Core investigators are well known for measurement and paradigm development, lifespan studies, and studies of higher functioning subjects across a range of IDDs.

临床翻译核心：摘要 UCLA IDDRC的转化临床核心的使命成立于2015年，是为了支持高质量， 多学科的，协作临床翻译研究的促进原因，预防，预防知识 诊断和治疗智力和发育障碍（IDD）。为此，核心将 提供研究咨询；获得降低的成本，专业，研究质量诊断和表型 评估；招聘支持；训练;数据管理；以及其他用于IDDRC调查人员桥接的辅助工具 基础科学的临床研究。该核心正在研究IDD研究的评估方法 通过创新的衡量发展，评估和传播。核心还支持外展， 生物测量银行和数据管理。此外，核心将参与IDDRC网络和其他 与IDDRC相关的多站点临床研究。 在过去的四年中，核心已成功建立了有效的程序来支持正在进行的 以及新的临床IDD研究，几乎使该时间范围内支持的数量增加了一倍，并贡献了 对现场的新表型测量。核心在支持几项新研究方面影响了 早期职业研究人员是临床研究的新手。在此续约中，我们通过添加两个来加强核心 新的核心共同投资者（凯瑟琳·洛德博士和鲁juta bhatt Wilson博士）为社交领域提供专业知识 诊断，行为，运动和神经系统评估，IDD干预试验，纵向研究以及 黄金标准诊断仪器的大规模培训。利用核心支持以实现大量 成本效率，降低个人项目成本以及消除培训的负担，质量控制和 维持个人研究的可靠性。然后，核心访问可以扩大研究工作和 通过在诊断，表型和进行中建立统一性来提高UCLA IDDRC研究的质量 临床研究。测量开发工作，利用复杂的分析（例如项目响应） 理论和机器学习旨在解决困扰先前临床的方法论差距 与IDD有关的研究工作，并通过提供更适合捕获临床的工具来促进新研究 潜在生物学的表现，从而提高临床翻译。我们的培训旨在为 IDD研究。我们的团队特别适合推进评估方法，以最少使用 口头的人，以及非常年幼的IDD风险，这是我们团队的优势。核心调查人员很好 以测量和范式开发，寿命研究和较高功能受试者的研究而闻名 遍布一系列IDD。