UCLA IDDRC: Translational Core

加州大学洛杉矶分校 IDDRC：转化核心

基本信息

批准号：
10426151
负责人：
JAMES T. MCCRACKEN
金额：
$ 19.16万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-01 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10426151
关键词：
Address Basic Science Behavioral Biology Child Clinical Clinical Investigator Clinical Research Clinical Trials Cognitive Competence Consultations Cost efficiency Development Diagnosis Diagnostic Evaluation Fostering Gold Individual Intellectual and Developmental Disabilities Research Centers Intellectual functioning disability Intervention Trial Knowledge Longevity Longitudinal Studies Machine Learning Maintenance Measurement Measures Methodology Methods Mission Motor Neurologic Patients Phenotype Prevention Procedures Quality Control Registries Research Research Design Research Personnel Risk Scientific Advances and Accomplishments Site Sleep Time Training Translational Research career clinical investigation clinical phenotype clinical research site clinical translation cost data management innovation instrument interest multidisciplinary novel outreach recruit response social theories tool translational goal translational study

项目摘要

Clinical Translational Core: Abstract The mission of the Translational Clinical Core of the UCLA IDDRC, established in 2015, is to support high quality, multidisciplinary, collaborative clinical translational research advancing knowledge of causes, prevention, diagnosis, and treatment of intellectual and developmental disabilities (IDDs). To accomplish this, the Core will provide research consultation; access to reduced cost, specialized, research quality diagnostic and phenotypic assessments; recruitment support; training; data management; and other aids for IDDRC investigators bridging clinical research with basic science. The Core is engaged in advancing assessment methods for IDD research through innovative measure development, evaluation, and dissemination. The Core also supports outreach, biospecimen banking, and data management. In addition, the Core will participate in IDDRC Network and other IDDRC-related multi-site clinical investigations. Over the past 4 years, the Core has successfully established effective procedures for support of ongoing and new clinical IDD studies, nearly doubling the number supported during that timeframe, and has contributed new phenotyping measurements to the field. The Core has been impactful in supporting several new studies by early career investigators new to clinical studies. In this renewal, we are strengthening the Core by adding two new Core Co-Investigators (Drs. Catherine Lord and Rujuta Bhatt Wilson) who bring special expertise in social, diagnostic, behavioral, motor, and neurological assessments, IDD intervention trials, longitudinal studies, and large-scale training on gold standard diagnostic instruments. Core support is leveraged to achieve substantial cost efficiency, reducing individual project costs and by removing burdens of training, quality control, and maintenance of reliability from individual studies. Core access then enables expansion of research efforts and enhances quality of UCLA IDDRC research by establishing uniformity in diagnosis, phenotyping, and conduct of clinical studies. Measurement development efforts, utilizing sophisticated analytics such as Item Response Theory and machine learning, are aimed at addressing methodologic gaps that have plagued prior clinical research efforts relating to IDDs, and foster new research by providing tools better suited to capturing clinical manifestations of underlying biology, hence advancing clinical translation. Our training aims to build capacity for IDD research. Our team is especially well suited for advancing assessment approaches for use in minimally verbal individuals, and very young children at risk for IDDs, a strength of our team. Core investigators are well known for measurement and paradigm development, lifespan studies, and studies of higher functioning subjects across a range of IDDs.

临床转化核心：摘要加州大学洛杉矶分校 IDDRC 转化临床核心成立于 2015 年，其使命是支持高质量、多学科、协作性临床转化研究推进对病因、预防、智力和发育障碍（IDD）的诊断和治疗。为了实现这一目标，核心将提供研究咨询；获得降低成本、专业化、研究质量的诊断和表型评估；招聘支持；训练;数据管理；以及为 IDDRC 调查人员提供的其他帮助临床研究与基础科学。该核心致力于推进 IDD 研究的评估方法通过创新措施的制定、评估和传播。核心还支持外展，生物样本库和数据管理。此外，Core还将参与IDDRC Network等 IDDRC 相关的多中心临床研究。在过去 4 年里，核心已成功建立有效的程序来支持持续的和新的临床 IDD 研究，在这段时间内支持的数量几乎翻了一番，并做出了贡献现场新的表型测量。核心在支持多项新研究方面发挥了重要作用刚刚接触临床研究的早期职业研究者。在这次更新中，我们通过添加两个来加强核心新的核心联合调查员（Catherine Lord 博士和 Rujuta Bhatt Wilson 博士）带来了社会、诊断、行为、运动和神经学评估、IDD 干预试验、纵向研究和关于黄金标准诊断仪器的大规模培训。利用核心支持来实现实质性目标成本效率，降低单个项目成本，并消除培训、质量控制和维持个别研究的可靠性。核心访问可以扩展研究工作并通过建立诊断、表型分析和实施的一致性来提高 UCLA IDDRC 研究的质量临床研究。测量开发工作，利用项目响应等复杂的分析理论和机器学习旨在解决困扰先前临床的方法论差距与 IDD 相关的研究工作，并通过提供更适合捕获临床数据的工具来促进新的研究基础生物学的表现，从而推进临床转化。我们的培训旨在培养以下方面的能力： IDD 研究。我们的团队特别适合推进评估方法以最小程度地使用善于言辞的人，以及面临 IDD 风险的幼儿，这是我们团队的优势。核心调查员状态良好以测量和范式发展、寿命研究以及高级功能受试者研究而闻名涵盖一系列 IDD。