The benefits of nicotinamide riboside upon cognition and sleep in older Veterans

烟酰胺核苷对老年退伍军人认知和睡眠的益处

• 批准号: 10686985
• 负责人: Carleara Weiss
• 金额: $ 10.45万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10686985
• 关键词: Academy; Activities of Daily Living; Adult; Age; Alzheimer' s Disease; American; Amyloid beta-42; Animal Model; Applied Research; Award; Basic Science; Behavioral; Biochemistry; Biological; Biological Markers; Biometry; Brain-Derived Neurotrophic Factor; Circadian Dysregulation; Circadian Rhythms; Clinical; Cognition; Conduct Clinical Trials; Data; Dementia; Discipline of Nursing; Elderly; Elements; Enrollment; Environment; Exhibits; Fellowship; Female; Foundations; Funding; Geriatric Assessment; Geriatrics; Goals; Growth; Hippocampus; Human; Impaired cognition; Impairment; Individual; International; Intervention; Knowledge; Language; Leadership; Learning; Measurement; Measures; Medicine; Memory; Memory impairment; Mentors; Mitochondria; Molecular; Molecular Biology; Mus; Niacinamide; Nicotinamide adenine dinucleotide; Nurses; Parents; Participant; Physical Performance; Pittsburgh Sleep Quality Index; Placebos; Psyche structure; Questionnaires; Research; Research Project Grants; Risk; Role; Science; Scientist; Serum; Severities; Silver; Sleep; Sleep disturbances; Sleeplessness; Societies; Supplementation; Synaptic plasticity; Techniques; Testing; Training; Training Programs; Treatment Cost; Tsunami; Underrepresented Minority; Universities; Veterans; Work; aged; aging population; career development; clinical development; clinical training; cognitive function; cognitive performance; diversity and inclusion; empowerment; executive function; experience; fitbit; functional outcomes; healthy aging; human old age (65+); improved; improvement on sleep; indexing; innovation; instrument; intervention cost; male; mild cognitive impairment; monocyte; nicotinamide riboside supplementation; nicotinamide-beta-riboside; peripheral blood; placebo group; poor sleep; potential biomarker; pre-clinical; prevent; programs; randomized, clinical trials; screening; skills; sleep quality; tau-1; wearable device

Project summary/ abstract Candidate: My overarching goal is to promote healthy aging through quality sleep as an independent nurse-scientist. My clinical training in geriatrics and behavioral sleep medicine and my pre-clinical fellowship in sleep and circadian disruptions lay the foundation for my expertise to reach this goal. This proposal will permit training in basic sciences applied to human studies to support the understanding of molecular mechanisms of poor sleep and cognitive impairment in older adults and their underlying interactions. The career development proposed in this application will empower my growth as an emerging leader from an underrepresented background with previous awards from the Sleep Research Society and American Academy of Sleep Medicine. Mentors and Environment: A prominent team of mentors and consultants has been assembled for this project. My primary mentor, Dr. Bruce Troen (Geriatrics) is an internationally recognized geriatrician and geroscientist. He will be assisted by co-mentors Dr. Rebecca Lorenz (Nursing, Geriatric, Sleep), Dr. Brienne Miner (Geriatrics, Sleep), Dr. Kenneth Seldeen (Geriatrics, Biochemistry); and advisors Dr. Nikhil Satchidanand (Geriatrics, Cognition), and Dr. Chang-Xing Ma (Biostatistics). We have created a training program to nurture research and leadership skills based upon the University at Buffalo and Yale University programs on geriatrics and sleep research for successul execution of the career development and reseach project outlined in this application. Mentored Research Project: Poor sleep quality and short sleep duration are associated with cognitive impairment in older adults and may be candidate mechanism underlying Alzheimer’s Disease and other dementias via impaired mitochondrial function and/or a reduced expression of brain-derived neurotrophic factor (BDNF). Our previous work indicated that enhancing the availability of nicotinamide adenine dinucleotide (NAD+) improves physical performance and cognition in aged mice and may reduce cognitive decline and support sleep quality by boosting mitochondrial function and enhancing BDNF expression. We propose to build upon a VA-funded randomized clinical trial investigating the effects of supplementation with the NAD+ precursor, nicotinamide riboside, a form of vitamin B3, upon physical performance in older adults, by examining the benefits of NR on sleep quality, objective sleep duration, and cognition in older adults. To accomplish these goals, we will assess sleep quality, objective sleep and cognitive function, as well as examine serum levels of BDNF of participants who receive a three-month supplementation with NR or placebo. This proposal will confirm the potential of NR as a low-risk and low-cost intervention for both healthy sleep and optimized cognitive function.

项目摘要/摘要 候选人：我的总体目标是通过作为独立的高质量睡眠来促进健康的衰老 护士科学家。我在老年医学和行为睡眠医学和临床前的临床培训 睡眠和昼夜节律干扰方面的研究金为我的专业知识奠定了基础。 提案将允许对适用于人类研究的基本科学进行培训，以支持对 老年人及其基础的睡眠不良和认知障碍的分子机制 互动。本应用程序提出的职业发展将使我成为新兴的成长能力 来自代表性不足的背景的领导者获得了睡眠研究协会的先前奖项和 美国睡眠医学学会。 导师和环境：为此组建了一个著名的导师和顾问团队 项目。我的主要导师布鲁斯·特伦（Bruce Troen）博士（老年医学）是一位国际认可的老年医生， Geroscientist。丽贝卡·洛伦兹（Rebecca Lorenz）博士（护理，老年，睡眠），博士将为他提供协助。 Brienne Miner（老年人，睡眠），Kenneth Seldeen博士（老年医学，生物化学）；和顾问博士 Nikhil Satchidanand（老年医学，认知）和Chang-Xing MA博士（生物统计学）。我们创建了一个 培训计划，根据布法罗大学和耶鲁大学的大学护理研究和领导技能 大学的老年医学和睡眠研究计划，以成功执行职业发展 并在此应用程序中概述了概述的项目。 指导研究项目：睡眠质量差和睡眠时间短与认知有关 老年人的损害，可能是阿尔茨海默氏病和其他的候选机制 痴呆通过线粒体功能受损和/或脑衍生神经营养的表达降低 因子（BDNF）。我们以前的工作表明，增强烟酰胺腺嘌呤的可用性 二核苷酸（NAD+）改善了老年小鼠的身体表现和认知，可能会减少 通过提高线粒体功能并增强BDNF，认知能力下降和支持睡眠质量 表达。我们建议建立在VA资助的随机临床试验的基础上，以调查 在物理上补充NAD+前体，烟酰胺核糖层，一种维生素B3的形式 通过检查NR对睡眠质量，客观睡眠持续时间的好处，在老年人中的表现， 和老年人的认知。为了实现这些目标，我们将评估睡眠质量，客观睡眠和 认知功能以及接受三个月的参与者的BDNF的检查血清水平 补充NR或安慰剂。该建议将确认NR作为低风险的潜力，并且 健康睡眠和优化认知功能的低成本干预。