The benefits of nicotinamide riboside upon cognition and sleep in older Veterans

烟酰胺核苷对老年退伍军人认知和睡眠的益处

• 批准号: 10835339
• 负责人: Carleara Weiss
• 金额: $ 7.53万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10835339
• 关键词: Academy; Administrative Supplement; Adult; Alzheimer' s Disease; American; Amyloid beta-42; Applied Research; Award; Basic Science; Behavioral; Biological Markers; Biometry; Brain-Derived Neurotrophic Factor; Childbirth; Circadian Dysregulation; Clinical; Clinical Sciences; Cognition; Collaborations; Consent; Consultations; Data; Data Analyses; Data Collection; Dementia; Discipline of Nursing; Elderly; Elements; Ensure; Environment; Enzyme-Linked Immunosorbent Assay; Epidemiology; Exhibits; Fees; Fellowship; Foundations; Geriatrics; Goals; Growth; Healthcare; Hippocampus; Human; Human Resources; Impaired cognition; Impairment; Institutional Review Boards; Intervention; K-Series Research Career Programs; Leadership; Measures; Medical center; Medicine; Memory; Memory impairment; Mentors; Mentorship; Mitochondria; Molecular; Mus; Niacinamide; Nicotinamide adenine dinucleotide; Nurses; Participant; Phase; Physical Performance; Pittsburgh Sleep Quality Index; Placebos; Pregnancy Complications; Productivity; Psyche structure; Questionnaires; Recovery; Research; Research Assistant; Research Design; Research Project Grants; Resources; Risk; School Nursing; Scientist; Secure; Serum; Services; Severities; Sleep; Sleep disturbances; Sleeplessness; Societies; Statistical Data Interpretation; Supplementation; Synaptic plasticity; Time; Training; Training Programs; Translational Research; United States Department of Veterans Affairs; United States National Institutes of Health; Universities; Veterans; Wages; Work; aged; career development; clinical development; clinical training; cognitive function; cognitive testing; data management; empowerment; executive function; experience; fitbit; functional outcomes; graduate student; healthy aging; human old age (65+); improved; improvement on sleep; indexing; intervention cost; mild cognitive impairment; nicotinamide riboside supplementation; nicotinamide-beta-riboside; patient screening; placebo group; placenta previa; poor sleep; pre-clinical; preservation; prevent; programs; randomized, clinical trials; screening; skills; sleep pattern; sleep quality; tau-1; undergraduate student; wearable device

Project summary/ abstract Candidate: My overarching goal is to promote healthy aging through quality sleep as an independent nurse-scientist. My clinical training in geriatrics and behavioral sleep medicine and my pre-clinical fellowship in sleep and circadian disruptions lay the foundation for my expertise to reach this goal. This proposal will permit training in basic sciences applied to human studies to support the understanding of molecular mechanisms of poor sleep and cognitive impairment in older adults and their underlying interactions. The career development proposed in this application will empower my growth as an emerging leader from an underrepresented background with previous awards from the Sleep Research Society and American Academy of Sleep Medicine. Mentors and Environment: A prominent team of mentors and consultants has been assembled for this project composed of Dr. Rebecca Lorenz (Primary Mentor, Nursing, Geriatric, Sleep), Dr. Brienne Miner, (Geriatrics, Sleep), and Dr. M. Jeffery Mador (Sleep, Veteran Healthcare). We have created a training program to nurture research and leadership skills based upon the University at Buffalo and Yale University programs on geriatrics and sleep research for successful execution of the career development and research project outlined in this application. Mentored Research Project: Poor sleep quality and short sleep duration are associated with cognitive impairment in older adults and may be candidate mechanism underlying Alzheimer’s Disease and other dementias via impaired mitochondrial function and/or a reduced expression of brain-derived neurotrophic factor (BDNF). Our previous work indicated that enhancing the availability of nicotinamide adenine dinucleotide (NAD+) improves physical performance and cognition in aged mice and may reduce cognitive decline and support sleep quality by boosting mitochondrial function and enhancing BDNF expression. We propose a randomized clinical trial investigating the effects of supplementation with the NAD+ precursor, nicotinamide riboside, a form of vitamin B3, on sleep quality, objective sleep duration, and cognition in older adults. To accomplish these goals, we will assess sleep quality, objective sleep and cognitive function, as well as examine serum levels of BDNF of participants who receive a three- month supplementation with NR or placebo. This proposal will confirm the potential of NR as a low-risk and low-cost intervention for both healthy sleep and optimized cognitive function.

项目摘要/摘要 候选人：我的总体目标是通过作为独立的高质量睡眠来促进健康的衰老 护士科学家。我在老年医学和行为睡眠医学和临床前的临床培训 睡眠和昼夜节律干扰方面的研究金为我的专业知识奠定了基础。 提案将允许对适用于人类研究的基本科学进行培训，以支持对 老年人及其基础的睡眠不良和认知障碍的分子机制 互动。本应用程序中提出的职业发展将使我成为我的成长 从代表性不足的背景中获得的新兴领导者获得了睡眠研究的先前奖项 协会和美国睡眠医学学会。 导师和环境：为此组建了一个著名的导师和顾问团队 由丽贝卡·洛伦兹（Rebecca Lorenz）博士（护理，老年医学，睡眠）组成的项目 （老年医学，睡眠）和M. Jeffery Mador博士（睡眠，资深医疗保健）。我们创建了培训 根据布法罗大学和耶鲁大学的大学护理研究和领导技能的计划 大学的老年医学和睡眠研究计划，以成功执行职业发展 和此应用程序中概述的研究项目。 指导研究项目：睡眠质量差和睡眠时间短与认知有关 老年人的损害，可能是阿尔茨海默氏病和其他的候选机制 痴呆通过线粒体功能受损和/或脑衍生神经营养的表达降低 因子（BDNF）。我们以前的工作表明，增强烟酰胺腺嘌呤的可用性 二核苷酸（NAD+）改善了老年小鼠的身体表现和认知，可能会减少 通过提高线粒体功能并增强BDNF，认知能力下降和支持睡眠质量 表达。我们提出了一项随机临床试验，研究补充 NAD+前体，烟酰胺核苷，一种维生素B3的形式，关于睡眠质量，客观睡眠持续时间， 和老年人的认知。为了实现这些目标，我们将评估睡眠质量，客观的睡眠 和认知功能以及接受三个参与者的BDNF的检查血清水平 用NR或安慰剂补充一个月。该建议将确认NR作为低风险的潜力 以及健康睡眠和优化认知功能的低成本干预。