Biomolecular Structure and Dynamics

生物分子结构与动力学

基本信息

批准号：
10684911
负责人：
BRUCE E BOWLER
金额：
$ 110.82万
依托单位：
UNIVERSITY OF MONTANA
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-10 至 2026-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10684911
关键词：
Acceleration Applications Grants Area Award Basic Science Biological Process Biomimetics Biophysics Budgets Centers of Research Excellence Charge Communities Computational Biology Core Facility Counseling Cryoelectron Microscopy Development Diabetes Mellitus Disease Docking Educational workshop Ensure Equipment Evolution Extramural Activities Faculty Fees Financial Support Fluorescence Fostering Foundations Funding Future Genes Genetic Transcription Goals Grant Grant Review Growth Health Human Humanities Image Imaging Techniques Incentives Infrastructure Institution Investments Laboratory Research Ligands Malignant Neoplasms Mass Spectrum Analysis Mathematical Biology Mentors Methods Mission Modernization Molecular Molecular Computations Monitor Montana Neurodegenerative Disorders Pathologic Peer Review Phase Physiological Processes Pilot Projects Positioning Attribute Proteomics Publications Research Research Personnel Research Support Resolution Resources Role Sampling Science Services Structural Chemistry Structure Translational Research United States National Institutes of Health Universities Water Work Writing base career cellular imaging cohort college design drug development drug discovery human pathogen imaging capabilities in vivo instrumentation macromolecule member metabolomics molecular dynamics novel therapeutics programs protein expression receptor research facility single molecule small molecule structural biology success two-dimensional

项目摘要

The Center of Biomedical Research Excellence in Biomolecular Structure and Dynamics (CBSD COBRE) at the University of Montana (UM) supports research that applies the methods and concepts of biophysics, structural biology and chemistry to understand the mechanistic basis of biological processes in health and disease. The CBSD COBRE draws from a pool of about 60 faculty members from the basic and biomedical sciences in the College of Humanities and Sciences and the College of Health. This phase III proposal builds on the successes of phases I and II of COBRE support for the CBSD that have led to the hiring of seven new faculty and early career support for an additional nine UM faculty. The direct COBRE support for their research efforts, the COBRE-supported research cores that underpin their research programs and the vibrant seminar and mentoring programs sponsored by the CBSD COBRE have propelled these early career investigators to success. As a cohort, they have been awarded 39 grants that brought in $16.8 million to support their research and have generated 83 well-cited peer-reviewed publications. During phases I and II, the CBSD COBRE has supported four research cores, the Integrated Structural Biology Core (ISBC), which provides gene to structure services, the BioSpectroscopy Core Research Laboratory (BCRL), which gives CBSD researchers access to state-of-the-art fluorescence lifetime and imaging instrumentation, the Molecular Computation Core Facility (MCCF), which provides molecular docking, drug discovery and molecular dynamics (MD) platforms, and the Mass Spectrometry Core Facility (MSCF), which applies proteomic and metabolomic approaches to CBSD research problems. The growth in the number of CBSD researchers afforded by investment in early career investigators and strong investment in research core infrastructure during phases I and II of COBRE support, which has included more than $2 million in new equipment resulting from extramural equipment grants, has positioned the CBSD well to attain long-term sustainability with phase III COBRE support. The CBSD COBRE will use the phase III COBRE to pursue three specific aims designed to sustain the CBSD beyond phase III. With specific aim 1, we will continue to expand the cutting-edge capabilities of our research cores by carefully prioritizing COBRE and institutional resources so that the cores respond to the needs of their users and by continuing to vigorously pursue extramural funding for equipment that enhances core infrastructure. Specific aim 2 will evolve the role of the Administrative Core to lead the CSBD to sustainability through strategic financial planning and ongoing mentoring programs that keep CBSD researchers across career stages at the leading edge of their research areas. Finally, specific aim 3 will develop a Pilot Project program designed to incentivize new scientific directions that not only use, but also expand the technical capabilities of our research cores. This carefully-designed framework will ensure the long-term sustainability of the CBSD and the vital research community that it supports.

生物分子结构和动力学卓越生物医学研究中心 (CBSD COBRE) 蒙大拿大学 (UM) 支持应用生物物理学方法和概念的研究，结构生物学和化学，了解健康和生物过程的机制基础疾病。 CBSD COBRE 从基础和生物医学领域约 60 名教职员工中选拔出来人文科学学院和健康学院的科学。该第三阶段提案构建关于 COBRE 对 CBSD 支持的第一阶段和第二阶段的成功，这导致雇用了七名新员工为另外九名密歇根大学教员提供教职和早期职业支持。 COBRE 对其研究的直接支持的努力、COBRE 支持的研究核心（支撑其研究计划）和充满活力的研讨会 CBSD COBRE 赞助的指导计划推动这些早期职业调查员成功。作为一个群体，他们获得了 39 项资助，为他们的研究带来了 1,680 万美元的资助并发表了 83 篇被广泛引用的同行评审出版物。在第一阶段和第二阶段，CBSD COBRE 已支持四个研究核心，即综合结构生物学核心（ISBC），它提供基因到结构服务，生物光谱核心研究实验室 (BCRL)，它为 CBSD 研究人员提供了访问最先进的荧光寿命和成像仪器，分子计算核心设施（MCCF），提供分子对接、药物发现和分子动力学（MD）平台，以及质谱核心设施 (MSCF)，将蛋白质组学和代谢组学方法应用于 CBSD 研究问题。早期职业投资带来的 CBSD 研究人员数量增长 COBRE 支持的第一阶段和第二阶段期间的研究人员和对研究核心基础设施的大力投资，其中包括超过 200 万美元的来自校外设备赠款的新设备，使 CBSD 能够在第三阶段 COBRE 支持下实现长期可持续性。 CBSD COBRE 将利用第三阶段 COBRE 来实现三个具体目标，旨在维持第三阶段之后的 CBSD。针对具体目标 1，我们将通过仔细研究，继续扩大我们研究核心的尖端能力。优先考虑 COBRE 和机构资源，以便核心响应其用户的需求，并通过继续大力寻求外部资金购买加强核心基础设施的设备。具体的目标 2 将发展行政核心的作用，通过战略性举措引导 CSBD 实现可持续发展财务规划和持续的指导计划使 CBSD 研究人员能够在整个职业阶段保持在其研究领域的前沿。最后，具体目标 3 将制定一个试点项目计划，旨在激励新的科学方向，不仅使用而且扩展我们研究的技术能力核心。这个精心设计的框架将确保 CBSD 的长期可持续性和重要的它支持的研究社区。