Biomolecular Structure and Dynamics: Equipment Supplement for Zeiss 880 Airyscan Upgrade

生物分子结构和动力学：Zeiss 880 Airyscan 升级的设备补充

• 批准号: 10580417
• 负责人: BRUCE E BOWLER
• 金额: $ 20.58万
• 依托单位: UNIVERSITY OF MONTANA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-10 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10580417
• 关键词: Applications Grants; Area; Award; Basic Science; Biological Process; Biomimetics; Biophysics; Budgets; Centers of Research Excellence; Communities; Computational Biology; Core Facility; Counseling; Cryoelectron Microscopy; Development; Diabetes Mellitus; Disease; Docking; Educational workshop; Ensure; Equipment; Evolution; Extramural Activities; Faculty; Fees; Financial Support; Fluorescence; Fostering; Foundations; Funding; Future; Genes; Genetic Transcription; Goals; Grant; Grant Review; Growth; Health; Human; Humanities; Imaging Techniques; Incentives; Infrastructure; Institutes; Investments; Laboratory Research; Lead; Ligands; Malignant Neoplasms; Mass Spectrum Analysis; Mathematical Biology; Mentors; Methods; Mission; Modernization; Molecular; Molecular Computations; Monitor; Montana; Neurodegenerative Disorders; Pathologic; Peer Review; Phase; Physiological Processes; Pilot Projects; Positioning Attribute; Proteomics; Publications; Research; Research Personnel; Research Support; Resolution; Resources; Role; Sampling; Science; Seeds; Services; Structural Chemistry; Structure; Translational Research; United States National Institutes of Health; Universities; Water; Work; Writing; base; career; cellular imaging; cohort; college; design; drug development; drug discovery; fluorescence lifetime imaging; human pathogen; imaging capabilities; in vivo; instrumentation; macromolecule; member; metabolomics; molecular dynamics; novel therapeutics; programs; protein expression; receptor; research facility; single molecule; small molecule; structural biology; success; two-dimensional

The Center of Biomedical Research Excellence in Biomolecular Structure and Dynamics (CBSD COBRE) at the University of Montana (UM) supports research that applies the methods and concepts of biophysics, structural biology and chemistry to understand the mechanistic basis of biological processes in health and disease. The CBSD COBRE draws from a pool of about 60 faculty members from the basic and biomedical sciences in the College of Humanities and Sciences and the College of Health. This phase III proposal builds on the successes of phases I and II of COBRE support for the CBSD that have led to the hiring of seven new faculty and early career support for an additional nine UM faculty. The direct COBRE support for their research efforts, the COBRE-supported research cores that underpin their research programs and the vibrant seminar and mentoring programs sponsored by the CBSD COBRE have propelled these early career investigators to success. As a cohort, they have been awarded 39 grants that brought in $16.8 million to support their research and have generated 83 well-cited peer-reviewed publications. During phases I and II, the CBSD COBRE has supported four research cores, the Integrated Structural Biology Core (ISBC), which provides gene to structure services, the BioSpectroscopy Core Research Laboratory (BCRL), which gives CBSD researchers access to state-of-the-art fluorescence lifetime and imaging instrumentation, the Molecular Computation Core Facility (MCCF), which provides molecular docking, drug discovery and molecular dynamics (MD) platforms, and the Mass Spectrometry Core Facility (MSCF), which applies proteomic and metabolomic approaches to CBSD research problems. The growth in the number of CBSD researchers afforded by investment in early career investigators and strong investment in research core infrastructure during phases I and II of COBRE support, which has included more than $2 million in new equipment resulting from extramural equipment grants, has positioned the CBSD well to attain long-term sustainability with phase III COBRE support. The CBSD COBRE will use the phase III COBRE to pursue three specific aims designed to sustain the CBSD beyond phase III. With specific aim 1, we will continue to expand the cutting-edge capabilities of our research cores by carefully prioritizing COBRE and institutional resources so that the cores respond to the needs of their users and by continuing to vigorously pursue extramural funding for equipment that enhances core infrastructure. Specific aim 2 will evolve the role of the Administrative Core to lead the CSBD to sustainability through strategic financial planning and ongoing mentoring programs that keep CBSD researchers across career stages at the leading edge of their research areas. Finally, specific aim 3 will develop a Pilot Project program designed to incentivize new scientific directions that not only use, but also expand the technical capabilities of our research cores. This carefully-designed framework will ensure the long-term sustainability of the CBSD and the vital research community that it supports.

生物分子结构与动力学卓越生物医学研究中心（CBSD Cobre） 蒙大拿大学（UM）支持应用生物物理学方法和概念的研究， 结构生物学和化学，以了解健康生物过程的机理基础 疾病。 CBSD毛茸茸从基本和生物医学的大约60名教职员工池中汲取 人文与科学学院的科学与卫生学院。该第三阶段提案建立 关于CBSD的CBSD的第一阶段和II阶段的成功，这导致了七个新的招聘 教师和早期的职业支持，为另外九个UM教师提供支持。对他们的研究的直接毛线支持 努力，脚底支持的研究核心，其研究计划和充满活力的研讨会 CBSD Cobre赞助的指导计划已将这些早期职业调查员推向 成功。作为一名同伙，他们获得了39赠予的赠款，带来了1,680万美元来支持他们的研究 并生成了83个备受推荐的同行评审出版物。在第I和II阶段，CBSD cobre具有 支持四个研究核心，即综合结构生物学核心（ISBC），它为结构提供了基因 服务，生物镜检查核心研究实验室（BCRL），该实验室使CBSD研究人员进入 最先进的荧光寿命和成像仪器，分子计算核心设施 （MCCF），它提供分子对接，药物发现和分子动力学（MD）平台以及 质谱核心设施（MSCF），将蛋白质组学和代谢组方法应用于CBSD 研究问题。早期职业投资提供的CBSD研究人员数量的增长 研究人员和在山洞支持I阶段I和II期间对研究核心基础设施的大量投资， 其中包括超过200万美元的新设备，由外壁外设备赠款，已有 将CBSD定位得很好，以通过III期毛线支持实现长期可持续性。 CBSD cobre 将使用第三阶段的鞋垫来追求三个旨在维持第三阶段CBSD的特定目标。 使用特定的目标1，我们将继续仔细地扩大我们研究核心的尖端功能 优先考虑毛豆和机构资源，以便核心响应用户的需求以及 继续大力为增强核心基础设施的设备提供壁外资金。具体的 AIM 2将发展行政核心的作用，使CSBD通过战略 财务计划和正在进行的指导计划使CBSD研究人员在职业阶段保持 他们的研究领域的前沿。最后，特定的目标3将制定旨在的试点项目计划 激励不仅使用的新科学方向，而且还扩展了我们研究的技术能力 内核。这个精心设计的框架将确保CBSD的长期可持续性和至关重要 它支持的研究社区。