The effect of electronic cigarette (ECIG) liquid vehicles on ECIG acute effects

电子烟（ECIG）液体载体对 ECIG 急性效应的影响

• 批准号: 8975845
• 负责人: Tory Richard Spindle
• 金额: $ 3.45万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-10 至 2018-08-09
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8975845
• 关键词: Acute; Address; Adolescent; Adult; Advocate; Aerosols; Affect; Behavior; Cigarette; Cigarette Smoker; Clinical; Collaborations; Data; Devices; Discipline; Dose; Drug Delivery Systems; Electronic cigarette; Elements; Fostering; Glycerol; Heating; Human; Individual; Label; Laboratories; Learning; Liquid substance; Marketing; Measures; Morbidity - disease rate; Nicotine; Nicotine Dependence; Outcome Measure; Pharmaceutical Preparations; Plasma; Population; Power Sources; Prevalence; Propylene Glycols; Public Health; Regulation; Research; Resistance; Solutions; Techniques; Tobacco; Toxicant exposure; Training; Vegetables; base; cigarette smoking; design; experience; mortality; nicotine abuse; novel; pre-clinical; pre-clinical research; public health relevance; voltage

 DESCRIPTION (provided by applicant): Electronic cigarettes (ECIGs) are among the most important issues in public health today due to their dramatic increase in popularity. However, very little is known about ECIGs, including what factors may make them more likely to be used and abused. Examining factors that influence nicotine yield, delivery, and subjective effects from ECIGs is essential to understanding their abuse liability. Limited pre-clinical research has revealed that nicotine yield may be influenced by the ratio of the two liquid vehicles, propylene glycol (PG) and vegetable glycerin (VG), most commonly found in ECIG solutions. Specifically, higher proportions of PG result in greater nicotine yields. However, the aerosols generated in this research were not produced by actual ECIG users' puffing behaviors, suggesting that the nicotine yields found may not be indicative of actual ECIG users' nicotine exposure. Moreover, the influence of PG:VG ratio on nicotine delivery and subjective effects associated with ECIG use has not been examined previously. This proposal describes a two-part study. The first examines the effect of PG and VG on nicotine delivery and subjective effects using a within-subjects design. Thirty experienced ECIG users will use an ECIG in five conditions that will differ only by the PG:VG ratio: 100:0, 70:30, 50:50, 30:70, and 0:100 (device voltage, heater resistance, liquid nicotine concentration, puff number, and interpuff interval all will be held constant). Plasma nicotine concentration, subjective effects, and puffing behaviors will be recorded in each condition. The second will generate ECIG aerosols using the puffing behavior recorded from ECIG users in the first part of the study and under identical experimental conditions (e.g., PG:VG ratio). The aerosol produced will be captured and assessed for nicotine yield. The primary hypotheses are that higher proportions of PG will result in greater nicotine delivery and subjective effect profiles suggestive of higher abuse liability in ECIG users and produce aerosols with higher nicotine yields. Results from this project will result in further understanding of the factors that influence the abuse liability of ECIGs and could inform regulation of these products.

 描述（由申请人提供）：电子烟 (ECIG) 因其受欢迎程度急剧上升而成为当今公共卫生中最重要的问题之一。然而，人们对电子烟 (ECIG) 知之甚少，包括哪些因素可能使它们更有可能被使用。研究影响 ECIG 尼古丁产生量、释放量和主观效应的因素对于了解其滥用倾向至关重要。有限的临床前研究表明，尼古丁产生量可能会受到两者比例的影响。液体载体、丙二醇 (PG) 和植物甘油 (VG)，最常见于 ECIG 溶液中。具体来说，较高比例的 PG 会产生较高的尼古丁产量。然而，本研究中产生的气溶胶并非由实际 ECIG 用户产生。吸烟行为，表明所发现的尼古丁产量可能并不代表实际 ECIG 用户的尼古丁暴露量，此外，PG:VG 比例对尼古丁输送和主观效果的影响。该提案描述了一项由两部分组成的研究，其中使用 30 名经验丰富的 ECIG 使用者进行了尼古丁输送和主观影响的研究。仅 PG:VG 比例不同的五种条件：100:0、70:30、50:50、30:70 和 0:100（设备电压、加热器电阻、液体尼古丁浓度、抽吸次数和抽吸间隔均将在每种条件下记录血浆尼古丁浓度、主观影响和抽吸行为。第二个将使用记录的抽吸行为生成 ECIG 气溶胶。来自 ECIG 用户的研究第一部分在相同的实验条件下（例如 PG:VG 比例）将捕获并评估产生的气溶胶的尼古丁含量。 PG 的比例将导致更大的尼古丁输送量和主观效应特征，表明 ECIG 使用者的滥用倾向更高，并产生具有更高尼古丁产量的气雾剂。该项目的结果将导致进一步了解影响 ECIG 滥用倾向的因素，并可能。告知这些产品的监管。