2023 Functional Genomics of Human Brain Development and Disease Gordon Research Conference

2023年人脑发育与疾病功能基因组学戈登研究会议

基本信息

批准号：
10683598
负责人：
ELISABETH B. BINDER
金额：
$ 2万
依托单位：
GORDON RESEARCH CONFERENCES
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-04-05 至 2024-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10683598
关键词：
Academia Acceleration Alzheimer&apos s Disease Biological Assay Biotechnology Brain Brain Diseases Career Choice Clustered Regularly Interspaced Short Palindromic Repeats Collaborations Complex DNA Sequence Development Diagnostic Disease Disease Progression Education Engineering Environment Epigenetic Process Female Fostering Future Gene Expression Regulation Generations Genes Genetic study Genome engineering Genomics Goals Grant Health Hour Human Industry Learning Maps Modeling Molecular Nerve Degeneration Neuroglia Neurologic Neurons Neurosciences Research Nobel Prize Organoids Participant Patients Postdoctoral Fellow Public Health Research Research Personnel Schizophrenia Scientist Stem Cell Research Technology Therapeutic Intervention Time Translating Underrepresented Minority United States National Academy of Sciences United States National Institutes of Health Universities Variant Wisconsin Woman autism spectrum disorder career clinically actionable disorder risk diversity and inclusion empowerment environmental enrichment for laboratory animals functional genomics genetic architecture genome editing genome-wide graduate student human disease human model human stem cells improved individualized medicine informal atmosphere insight male meetings member multidisciplinary neurogenomics new technology new therapeutic target novel novel strategies posters prognostic programs stem cell model stem cells symposium tool

项目摘要

Project Summary/Abstract This 2023 Functional Genomics of Human Brain Development and Disease GRC conference seeks to bring together a multidisciplinary and diverse group of geneticists, neuroscientists, and stem cell biologists endeavoring to improve diagnostics, prognostics, and treatment of brain disease. The conference will explore (1) genomics of brain diseases, (2) applications of high-throughput genomic assays and screens, (3) technological advances in reprogramming, differentiation, and genome-engineering; (4) new insights into human brain development and disorders obtained through technologies; and (5) progress towards novel therapeutic targets and interventions. Whereas large-scale genomic studies are uncovering the complex genetic architecture of gene regulation and disease risk, the causal cellular mechanisms of disease risk and progression remain unclear. While the generation of patient-specific neurons, glia, and organoids facilitate the study of human brain development, CRISPR-based engineering approaches facilitate single or genome-wide perturbations in DNA sequence or epigenetic activity; their integration makes it possible to investigate the molecular mechanisms of disease-associated variations. Together, these approaches translate the myriad advances from large-scale genetic studies into clinically actionable information. This 2023 Functional Genomics of Human Brain Development and Disease GRC conference will contribute to improving our understanding the cellular and molecular mechanisms involved in regulating human brain development in health and disease. The attendees are also expected to form new connections with the leaders in industry and academia for setting new collaborations and starting new careers.

项目摘要/摘要这次2023年人脑发育和疾病GRC会议的功能基因组学旨在带来综合多学科和多样化的遗传学家，神经科学家和干细胞生物学家努力改善诊断，预后和脑部疾病的治疗。会议将探索（1）脑疾病的基因组学，（2）高通量基因组测定和筛查的应用，（3）在重编程，分化和基因组工程方面的技术进步；（4）新见解通过技术获得的人脑发育和疾病；（5）迈向小说治疗目标和干预措施。而大规模的基因组研究正在发现复合物基因调控和疾病风险的遗传结构，疾病风险的因果细胞机制和进展仍然不清楚。而患者特异性神经元，神经胶质和器官的产生促进了基于CRISPR的工程方法的人脑发育研究有助于单一或基因组 DNA序列或表观遗传活性的扰动；他们的整合使调查疾病相关变异的分子机制。这些方法一起翻译了无数大规模遗传研究的进步临床可起作的信息。这次2023年人脑发育和疾病GRC会议的功能基因组学将有助于提高我们的了解与调节人脑有关的细胞和分子机制健康和疾病的发展。预计与会者还将与领导者建立新的联系在工业和学术界建立新的合作并开始新职业的学术界。