CINCINNATI TRAINING PROGRAM IN PEDIATRIC RHEUMATOLOGYRESEARCH

辛辛那提儿科风湿病学研究培训计划

• 批准号: 10682443
• 负责人: ALEXEI A GROM
• 金额: $ 14.17万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10682443
• 关键词: Childhood; Training Programs

PROJECT SUMMARY/ABSTRACT This T32 application seeks to equip pediatric rheumatology fellows with the investigative skills necessary to succeed in meaningful scientific careers in academic pediatric rheumatology. The program is based in a large Division of Pediatric Rheumatology (PR) with several center grants and NIH-funded investigators. The Pediatric Rheumatology Division, including its related clinic, is part of Cincinnati Children's Hospital Medical Center (CCHMC) and The Children's Hospital Research Foundation (TCHRF), as well as part of the University of Cincinnati College of Medicine (UCCOM) with its clinical and biomedical science departments. The Pediatric Rheumatology divisional research program draws strength from uniquely integrated teams of clinical, translational and basic researchers involved in active ongoing collaborations with members of Divisions of Immunobiology, Human Genetics, Hematology/Oncology, Bone Marrow Transplantation, Nephrology, Pharmacology, Radiology, Psychology and Bioinformatics. The primary faculty advisors were selected from 15 specialties divisions based on the ongoing collaboration with Rheumatology faculty, high research productivity and strong record of training of young scientists. Although the main emphasis will be placed on MD and MD/PhD trainees in the PR Fellowship Program, PhD candidates with strong interest in translational research in pediatric rheumatologic diseases will be sought as well. The majority of trainees will focus their research and training activities in one of the two special emphasis areas of strength, unique to the CCHMC research center and the Division of Rheumatology: (1) application of bioinformatics and “omics” technologies including genomics, epigenetics, proteomics, and metabolomics to advance translational research related to pediatric rheumatology, and (2) clinical epidemiology, development of clinical outcome assessment tool and clinical trial design. The program is well supported by core facilities as well as by academic courses, including a mandatory course in medical ethics. Other available courses include computational system biology, immunobiology, molecular genetics, and epidemiology and biostatistics. The interdepartmental Immunobiology Graduate Program (MS and PhD) that is centered at CCHMC complements existing programs in Epidemiology and Biostatistics, and Education in the UCCOM. It is believed that this Training Program for Pediatric Rheumatic Disease Research provides unique resources and will continue to enlarge the pool of individuals with a career interest in biomedical science as it relates to pediatric rheumatology, a pool that is far too small to meet the requirements of the next decades as molecular medicine is increasingly applied in the clinic.

项目摘要/摘要 该T32应用程序旨在为小儿风湿病研究员配备调查技能 在学术儿科风湿病学领域取得有意义的科学职业所必需的。 计划基于多个中心补助金的小儿风湿病学（PR） 和NIH资助的调查员。小儿风湿病科，包括其相关诊所， 是辛辛那提儿童医院医疗中心（CCHMC）和儿童医院的一部分 研究基金会（TCHRF）以及辛辛那提大学学院的一部分 医学（UCCOM）及其临床和生物医学科学部门。小儿 风湿病学部门研究计划从独特的综合团队中汲取了力量 临床，翻译和基础研究人员与与 免疫生物学，人类遗传学，血液学/肿瘤学，骨骼的划分成员 骨髓移植，肾脏病，药理学，放射学，心理学和 生物信息学。主要的教师顾问是从15个专业部门中选出的 关于与风湿病学的持续合作，高研究生产力和强大的 年轻科学家的培训记录。尽管主要重点将放在MD和 公关奖学金计划中的MD/博士学位学员，对博士候选人有浓厚兴趣的候选人 小儿风湿病的转化研究也将被感受。大多数 受训人员将在两个特殊重点领域之一的研究和培训活动中重点 强度，CCHMC研究中心独有的和风湿病分工：（1） 生物信息学和“ OMICS”技术的应用，包括基因组学，表观遗传学， 蛋白质组学和代谢组学以推进与小儿有关的转化研究 风湿病学和（2）临床流行病学，临床结果评估工具的开发 和临床试验设计。该计划得到了核心设施以及学术的良好支持 课程，包括医学伦理学的强制性课程。其他可用课程包括 计算系统生物学，免疫生物学，分子遗传学和流行病学以及 生物统计学。部门间免疫生物学研究生课程（MS和PHD） 集中于CCHMC完成流行病学和生物统计学的现有计划，以及 UCCOM的教育。人们认为这项针对小儿风湿的培训计划 疾病研究提供了独特的资源，并将继续扩大个人库 对生物医学科学的职业兴趣与儿科风湿病有关，一个游泳池是 太小了，无法满足未来几十年的要求，因为分子医学是 越来越多地应用于诊所。