Early Predictors of Cognitive/Language Development

认知/语言发展的早期预测因素

• 批准号: 10678906
• 负责人: Timothy P Roberts
• 金额: $ 28.01万
• 依托单位: CHILDREN'S HOSP OF PHILADELPHIA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-15 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10678906
• 关键词: 3 year old; 6 year old; Acceleration; Activities of Daily Living; Adopted; Affect; Age; Age Years; Auditory; Auditory Evoked Potentials; Auditory area; Behavior; Biological Markers; Brain; Brain region; Caregivers; Child; Clinical; Clinical assessments; Cognitive; Communication; Detection; Development; Diagnosis; Down Syndrome; Electrophysiology (science); Enrollment; Event; Future; Gene Mutation; Genetic Risk; Genomics; Goals; Impairment; Individual; Infant; Intellectual and Developmental Disabilities Research Centers; Intellectual functioning disability; Intervention; Laboratories; Language; Language Development; Magnetoencephalography; Measures; Nature; Nursery Schools; Outcome; Outcome Assessment; Parents; Phase; Predictive Value; Procedures; Process; Prospective cohort; Reporting; Research; Research Design; Research Project Grants; Resolution; Response Latencies; Risk; Scanning; Schedule; School-Age Population; Services; Severities; Source; Specific qualifier value; Specificity; Standardization; Stimulus; Syndrome; Time; Toddler; aged; autistic children; clinical diagnosis; cognitive ability; cohort; design; follow-up; functional outcomes; functional status; genetic disorder diagnosis; improved; innovation; interest; lexical; longitudinal design; minimally verbal; neural; neural correlate; non-verbal; outcome prediction; predictive marker; recruit; risk stratification; specific language impairment; success

(RESEARCH PROJECT- EARLY PREDICTORS OF COGNITIVE/LANGUAGE DEVELOPMENT) PROJECT SUMMARY This project aims to identify electrophysiological markers (using magnetoencephalography, MEG) that predict future intellectual ability in infants and toddlers at risk for intellectual and developmental disability (IDD). To this end, we will use a suite of MEG paradigms developed in the previous IDDRC cycle that show differential sensitivity to general cognitive and language-specific ability. Paradigms focus on assessment of primary (pure tones) through higher-order (lexical access) auditory cortex activity. With the obtained auditory cortex neural measures used (singly and combined) we will predict future functional status (cognitive and language). Infant- optimized versions of these paradigms are applied to infants at genetic risk of a subsequent intellectual disability diagnosis. Hence, we hypothesize that early assessment of electrophysiological activity in at-risk infants will not only quantitatively indicate the degree of risk but will also predict and specify the nature of impairment. Given that most clinical diagnoses of intellectual disability are not made until at least school-age years, an accelerated longitudinal design is invoked. First, an Infant phase studies babies at 6, 12 and then 18 months in an attempt to predict functional status at 36 months. A simultaneously recruited Preschool phase recruits toddlers at age 3 years with similar genetic diagnoses (at-risk for IDD) to predict functional outcome assessment obtained at age 6 years. Via this research design, the interim functional follow-up of 3 year olds initially scanned as 6, 12 and 18-month infants can be better interpreted with respect to prediction of outcome at age 6 years. Through serial MEG examination, instantaneous (e.g., 6, 12 or 18 months) assessments as well as developmental trajectories (6- to 12- to 18-month interval change) are interrogated for their predictive value. With respect to innovation, given the temporal and spatial resolution of brain activity that is almost unique to MEG, MEG is poised to greatly enhance our understanding of normal and abnormal infant and toddler brain development. Specially, in addition to noted use of exams that directly target a range of primary/secondary auditory cortex neural processes, analyses that provide measures of brain activity in source space allow for focused assessment of activity at brain regions of a priori interest versus examining a composite measure of whole-brain activity. It is anticipated that early repeated assessment of brain activity of infants at risk for an IDD diagnosis will provide actionable information to parents and caregivers and, where needed, allow earlier tailored interventions.

（研究项目 - 认知/语言发展的早期预测指标） 项目摘要 该项目旨在识别预测的电生理标记（使用磁脑电图，MEG） 婴儿和幼儿的未来智力能力有智力和发育障碍风险（IDD）。对此 最后，我们将使用在上一个IDDRC周期中开发的MEG范式，该范式显示出差异 对一般认知和语言特定能力的敏感性。范式专注于评估原则（纯 通过高阶（词汇访问）听觉皮层活动的音调）。带有获得的听觉皮层神经 使用（单一合并）的措施我们将预测未来的功能状态（认知和语言）。婴儿- 这些范式的优化版本适用于以随后的智障遗传风险的婴儿 诊断。因此，我们假设对处于危险的婴儿的电生理活性的早期评估不会 仅定量表示风险程度，但还将预测和指定损害的性质。给出 大多数智力残疾的临床诊断至少要等到学年才能加速 纵向设计被调用。首先，婴儿期在6、12和18个月的尝试中研究婴儿 预测36个月的功能状态。同时在3岁时同时招募的学龄前招募幼儿 具有类似遗传诊断的年份（IDD的高危诊断），以预测年龄获得的功能结果评估 6年。通过这种研究设计，最初扫描为6、12和 可以更好地解释18个月的婴儿在6岁时预测结果。通过系列 MEG检查，瞬时（例如6、12或18个月）评估以及发展轨迹 （6到12到12个月的间隔变化）的预测价值受到询问。关于创新， 鉴于MEG几乎独有的脑活动的时间和空间分辨率，MEG已准备好大大 增强我们对正常和异常婴儿和幼儿脑发育的理解。特别是，此外 指定的使用直接针对一系列主要/二级听觉皮层神经过程的考试， 提供源空间中大脑活动量度的分析允许重点评估大脑的活动 先验兴趣的区域与检查全脑活动的综合度量。预计 早期重复评估有IDD诊断风险的婴儿的大脑活动将提供可行的 向父母和看护人提供信息，并在需要时允许更早的量身定制干预措施。