Early Predictors of Cognitive/Language Development

认知/语言发展的早期预测因素

基本信息

批准号：
10240005
负责人：
Timothy P Roberts
金额：
$ 18.91万
依托单位：
CHILDREN'S HOSP OF PHILADELPHIA
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-15 至 2026-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10240005
关键词：
3 year old 6 year old Activities of Daily Living Adopted Affect Age Age-Years Auditory Auditory Evoked Potentials Auditory area Behavior Biological Markers Brain Brain region Caregivers Child Clinical Clinical assessments Cognitive Communication Detection Development Diagnosis Down Syndrome Electrophysiology (science)Enrollment Event Future Gene Mutation Genetic Risk Genomics Goals Impairment Individual Infant Intellectual and Developmental Disabilities Research Centers Intellectual functioning disability Intervention Laboratories Language Language Development Magnetoencephalography Measures Nature Nursery Schools Outcome Outcome Assessment Parents Phase Predictive Value Procedures Process Prospective cohort Reporting Research Research Design Research Project Grants Resolution Response Latencies Risk Scanning Schedule School-Age Population Services Severities Source Specific qualifier value Specificity Standardization Stimulus Syndrome Time Toddler aged autistic children clinical Diagnosis cognitive ability cohort design follow-up functional outcomes functional status genetic disorder diagnosis improved innovation interest lexical longitudinal design neural correlate outcome prediction predictive marker recruit relating to nervous system risk stratification specific language impairment success

项目摘要

(RESEARCH PROJECT- EARLY PREDICTORS OF COGNITIVE/LANGUAGE DEVELOPMENT) PROJECT SUMMARY This project aims to identify electrophysiological markers (using magnetoencephalography, MEG) that predict future intellectual ability in infants and toddlers at risk for intellectual and developmental disability (IDD). To this end, we will use a suite of MEG paradigms developed in the previous IDDRC cycle that show differential sensitivity to general cognitive and language-specific ability. Paradigms focus on assessment of primary (pure tones) through higher-order (lexical access) auditory cortex activity. With the obtained auditory cortex neural measures used (singly and combined) we will predict future functional status (cognitive and language). Infant- optimized versions of these paradigms are applied to infants at genetic risk of a subsequent intellectual disability diagnosis. Hence, we hypothesize that early assessment of electrophysiological activity in at-risk infants will not only quantitatively indicate the degree of risk but will also predict and specify the nature of impairment. Given that most clinical diagnoses of intellectual disability are not made until at least school-age years, an accelerated longitudinal design is invoked. First, an Infant phase studies babies at 6, 12 and then 18 months in an attempt to predict functional status at 36 months. A simultaneously recruited Preschool phase recruits toddlers at age 3 years with similar genetic diagnoses (at-risk for IDD) to predict functional outcome assessment obtained at age 6 years. Via this research design, the interim functional follow-up of 3 year olds initially scanned as 6, 12 and 18-month infants can be better interpreted with respect to prediction of outcome at age 6 years. Through serial MEG examination, instantaneous (e.g., 6, 12 or 18 months) assessments as well as developmental trajectories (6- to 12- to 18-month interval change) are interrogated for their predictive value. With respect to innovation, given the temporal and spatial resolution of brain activity that is almost unique to MEG, MEG is poised to greatly enhance our understanding of normal and abnormal infant and toddler brain development. Specially, in addition to noted use of exams that directly target a range of primary/secondary auditory cortex neural processes, analyses that provide measures of brain activity in source space allow for focused assessment of activity at brain regions of a priori interest versus examining a composite measure of whole-brain activity. It is anticipated that early repeated assessment of brain activity of infants at risk for an IDD diagnosis will provide actionable information to parents and caregivers and, where needed, allow earlier tailored interventions.

（研究项目 - 认知/语言发展的早期预测因子）项目概要该项目旨在识别预测的电生理标记（使用脑磁图，MEG）存在智力和发育障碍 (IDD) 风险的婴幼儿未来的智力能力。对此最后，我们将使用在之前的 IDDRC 周期中开发的一套 MEG 范例，这些范例显示了差异对一般认知和语言特定能力的敏感性。范式侧重于初级（纯音调）通过高阶（词汇访问）听觉皮层活动。利用获得的听觉皮层神经使用的措施（单独和组合）我们将预测未来的功能状态（认知和语言）。婴儿- 这些范例的优化版本适用于具有随后智力障碍遗传风险的婴儿诊断。因此，我们假设对高危婴儿的电生理活动进行早期评估不会不仅可以定量地表明风险程度，还可以预测和明确减值的性质。给定大多数智力障碍的临床诊断至少要到学龄期才做出，加速调用纵向设计。首先，婴儿阶段尝试研究 6 个月、12 个月和 18 个月大的婴儿预测 36 个月时的功能状态。同时招募的学前班阶段招募 3 岁幼儿具有类似遗传诊断（有 IDD 风险）的年份来预测在年龄时获得的功能结果评估 6年。通过这项研究设计，对 3 岁儿童的临时功能随访最初扫描为 6 岁、12 岁和 18 个月大的婴儿可以更好地预测 6 岁时的结果。通过串口 MEG 检查、瞬时（例如 6、12 或 18 个月）评估以及发育轨迹（6 至 12 至 18 个月的间隔变化）被询问其预测价值。在创新方面，考虑到脑活动的时间和空间分辨率几乎是 MEG 所独有的，MEG 有望大大提高增强我们对正常和异常婴幼儿大脑发育的了解。特别地，此外注意到直接针对一系列初级/次级听觉皮层神经过程的检查的使用，提供源空间中大脑活动测量的分析可以对大脑活动进行集中评估先验感兴趣的区域与检查全脑活动的综合测量。预计对有 IDD 诊断风险的婴儿的大脑活动进行早期重复评估将提供可操作的依据向父母和照顾者提供信息，并在需要时允许尽早进行量身定制的干预措施。