Self-reflective accuracy across subclinical dimensions of psychopathology
精神病理学亚临床维度的自我反思准确性
基本信息
- 批准号:10679418
- 负责人:
- 金额:$ 7.32万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-04-01 至 2026-03-31
- 项目状态:未结题
- 来源:
- 关键词:AgeAlcohol consumptionAlcoholic beverage heavy drinkerAlcoholsAreaAttentionBehaviorBehavioralBeliefBenchmarkingBrainClinicalClinical TrialsCognitiveCognitive ScienceComputer ModelsDecision MakingDimensionsDiseaseEnvironmentEventFacultyFellowshipFundingFutureGenderGeneral PopulationGoalsHealthHomeImpairmentIndividualIndividual DifferencesInterventionInvestigationLearningLinkLocationMeasuresMediatingMental DepressionMental ProcessesMentorsMentorshipMindfulness TrainingModelingNeurocognitiveObsessive compulsive behaviorObsessive-Compulsive DisorderParticipantPatient Self-ReportPersonal SatisfactionPersonsPopulationProcessPsychiatryPsychopathologyRaceReportingResearchSamplingSelf-ExaminationSeveritiesSubstance Use DisorderSymptomsTestingTherapeutic InterventionThinkingTimeTrainingTranslatingUnited States National Institutes of HealthVariantWeightWorkalcohol cravingalcohol cuealcohol involvementalcohol responsealcohol use disordercognitive processdiagnostic biomarkerfollow-upimprovedinsightmindfulness interventionnovelpsychiatric symptomschizophrenia spectrum disordersocial
项目摘要
Project Summary/Abstract. “Why did I choose to do that?” Being able to answer this common question – and
accurately reflect on the mental processes underlying one’s choices – is fundamental to good decision-making
and healthy relationships. This capacity is impaired in some forms of psychopathology; inaccurate
self-reflection appears related to psychiatric symptoms in diverse areas such as schizophrenia spectrum
disorders, obsessive-compulsive disorder, and substance use disorders1–12, and improving self-reflection is a
goal of many therapeutic interventions13–16. Yet, the neurocognitive mechanisms underlying self-reflective
(in)accuracy are poorly understood because the field lacks objective, quantitative measures of this ability.
I propose to use a novel measure (which I’ve developed and piloted) to quantify people’s self-reflective
accuracy about their choice processes, and relate this accuracy to psychiatric symptom variation in the
general population. In this task, participants first make choices between options (e.g., homes to rent, or social
events to attend) which vary on many attributes17,18. Then, participants report how they believe they made their
choices, including how much weight they placed on each attribute and how they combined the attributes
together. I then fit a set of established models to participants’ choices17,19, recovering key aspects of their
choice process. By comparing participants’ self-reports to the process revealed in their actual choices, I
can obtain an objective measure of participants’ self-reflective accuracy about their choice process.
Using this measure, I will test whether schizotypy and obsessive-compulsive symptoms (in a
general-population sample) correlate with lower self-reflective accuracy (Study 1), and whether
symptoms of disordered alcohol use correlate with lower accuracy in the specific context of choices
involving alcohol (Study 2). Finally, I will add my measure to an ongoing NIH-funded clinical trial testing
whether a mindfulness intervention can reduce alcohol consumption among heavy drinkers. I will test whether
this mindfulness intervention improves self-reflective accuracy in alcohol-related choice20,21, and
whether improvements in accuracy mediate reductions in alcohol consumption22–24 (Study 3). This research
provides a generative paradigm for quantifying self-reflective accuracy in choice, supporting future investigation
into the neurocognitive mechanisms underlying self-reflection and its disruption in psychopathology1,3,7,9,10,25
and offering a benchmark for validating future therapeutic interventions26.
My background is in computational models of choice27–30, and in this fellowship I will learn to apply these models
to psychopathology. My mentor team includes experts in computational cognitive science, psychopathology,
computational psychiatry, clinical interventions, and self-understanding, and the training plan involves substantial
coursework, one-on-one mentorship, and seminar attendance. Moreover, Princeton – with its world-renowned
faculty in computational psychiatry – offers an unparalleled environment to conduct this research and training.
项目摘要/摘要。 “我为什么选择这样做?”能够回答这个常见的问题 - 并且
准确地反思自己选择的心理过程 - 对于良好的决策至关重要
和健康的关系。这种能力在某些形式的心理病理学中受损。不准确
自我反省似乎与精神分裂症等潜水区域的精神病症状有关
疾病,强迫症和药物使用障碍1-12和改善自我反省是一种
许多治疗干预措施的目标13-16。然而,自我反射的神经认知机制
(IN)准确性很少理解,因为该领域缺乏客观的,定量的衡量标准。
我建议使用一种新颖的测量(我已经开发并进行了试点)来量化人们的自我反射
他们选择过程的准确性,并将这种准确性与精神病症状变化相关
一般人口。在此任务中,参与者首先在选项之间做出选择(例如,出租房屋或社交房屋
参加的活动)在许多属性上有所不同。17,18。然后,参与者报告他们如何相信自己
选择,包括他们在每个属性上放置多少重量以及如何组合属性
一起。然后,我将一组既定的模型适合参与者的选择17,19,恢复了他们的关键方面
选择过程。通过将参与者的自我报告与实际选择中揭示的过程进行比较,我
可以客观地测量参与者对他们的选择过程的自我反思准确性。
使用此措施,我将测试是否存在精神分裂症和强迫性症状(在
大型人群样本)与较低的自我反射精度相关(研究1),以及是否是否
在选择的特定背景下,酒精使用障碍的症状与精度较低相关
涉及酒精(研究2)。最后,我将我的测量值添加到正在进行的NIH资助的临床试验测试中
正念干预是否可以减少大量饮酒者的酒精消耗。我会测试是否
这种正念干预提高了与酒精相关选择的自我反射精度20,21,并且
是否改善酒精消耗的准确性介质降低22-24(研究3)。这项研究
提供了一个通用范例,用于量化选择的自我反射精度,并支持未来的调查
进入自我反省基础的神经认知机制及其在心理病理学中的破坏1,3,7,9,10,25
并提供用于验证未来治疗干预措施的基准26。
我的背景是选择27-30的计算模型,在此奖学金中,我将学会应用这些模型
我的心理团队包括计算认知科学专家,心理病理学,
计算精神病学,临床干预和自我理解,培训计划涉及大量
课程工作,一对一的心态和半接触。而且,普林斯顿 - 享誉世界
计算精神病学的教师 - 提供了无与伦比的环境来进行这项研究和培训。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Adam Mitchell Morris其他文献
Adam Mitchell Morris的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
相似国自然基金
饮酒刺激肝细胞分泌外泌体对股骨头内H型血管的影响及分子机制
- 批准号:82272508
- 批准年份:2022
- 资助金额:52 万元
- 项目类别:面上项目
不同饮酒模式下CD11b+Ly6Chigh细胞群的分化及其对酒精性肝损伤的调控机制研究
- 批准号:
- 批准年份:2022
- 资助金额:30 万元
- 项目类别:青年科学基金项目
不同饮酒模式下CD11b+Ly6Chigh细胞群的分化及其对酒精性肝损伤的调控机制研究
- 批准号:82200656
- 批准年份:2022
- 资助金额:30.00 万元
- 项目类别:青年科学基金项目
定量设定法定最低饮酒年龄的方法研究
- 批准号:82103950
- 批准年份:2021
- 资助金额:24.00 万元
- 项目类别:青年科学基金项目
伏隔核多巴胺信号通过调节D1R-、D2R-MSNs活动影响个体差异饮酒行为的机制研究
- 批准号:
- 批准年份:2021
- 资助金额:30 万元
- 项目类别:青年科学基金项目
相似海外基金
Longitudinal Impacts of Pandemic-Induced Disruptions on Adolescent Siblings' and Parents' Alcohol Use: A Family Life Course Perspective
流行病引起的干扰对青少年兄弟姐妹和父母饮酒的纵向影响:家庭生活历程的视角
- 批准号:
10470569 - 财政年份:2022
- 资助金额:
$ 7.32万 - 项目类别:
Chronic Alcohol, Dementia, and CNS Fluid Homeostasis
慢性酒精、痴呆和中枢神经系统液体稳态
- 批准号:
10706469 - 财政年份:2022
- 资助金额:
$ 7.32万 - 项目类别:
Longitudinal Impacts of Pandemic-Induced Disruptions on Adolescent Siblings' and Parents' Alcohol Use: A Family Life Course Perspective
流行病引起的干扰对青少年兄弟姐妹和父母饮酒的纵向影响:家庭生活历程的视角
- 批准号:
10629339 - 财政年份:2022
- 资助金额:
$ 7.32万 - 项目类别:
Dynamic Personalized Feedback for Young Adults with a History of Alcohol-Induced Blackout
为有酗酒史的年轻人提供动态个性化反馈
- 批准号:
10620609 - 财政年份:2022
- 资助金额:
$ 7.32万 - 项目类别:
Determining the Longer-term Impact of COVID-19 Stressors, Alcohol Use and Neurobiobehavioral Decline in Older Adults Through Prospective Study
通过前瞻性研究确定 COVID-19 压力源、饮酒和神经生物行为下降对老年人的长期影响
- 批准号:
10579335 - 财政年份:2022
- 资助金额:
$ 7.32万 - 项目类别: