UAB Core Grant for Vision Research

UAB 视觉研究核心资助

基本信息

批准号：
10681446
负责人：
Brian Christopher Samuels
金额：
$ 74.06万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-08-01 至 2026-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10681446
关键词：
Affect Age related macular degeneration American Anatomy Animal Model Area Award Benchmarking Big Data Biochemical Biometry Caliber Cataract Cells Collaborations Complement Computer Analysis Computer software Computers and Advanced Instrumentation Consensus Core Facility Core Grant Custom DNA Data Analyses Database Management Systems Databases Development Diagnostic Disease Doctor of Philosophy Elements Ensure Equipment Expenditure Experimental Designs Extramural Activities Eye diseases Faculty First Independent Research Support and Transition Awards Funding Glaucoma Goals Grant Growth Hour Image Image Analysis Individual Institution K-Series Research Career Programs Keratoconus Maintenance Modality Molecular Monitor Morphology Myopia Names Outcome Participant Phenotype Physiological Productivity Proteins Psychophysics Publications Quality of life RNA Request for Applications Research Research Activity Research Design Research Personnel Research Project Grants Research Support Resource Sharing Resources Retina Retinitis Pigmentosa Scientific Inquiry Scientist Services Structure Surveys Technology Time Tissues Training United States National Institutes of Health Vision Vision Disorders Vision research Visual Pathways analytical tool career computer program design experimental analysis eye dryness human model improved innovation instrument instrumentation mechanical device meetings novel programs recruit repaired satisfaction skills success synergism vision science visual neuroscience

项目摘要

UAB Center for Vision Research - Overall Core Project Summary/Abstract In 1979, an NEI Core grant was first awarded to UAB. Over the next 41 years, the institution's commitment to strategic growth resulted in significant expansion of vision research. Participants have increased from 13 in 2 departments to 25 in 3 departments, with a concominant increase in extramural funding. Twenty participants currently hold 24 eligble NEI R01 grants. One participant has submitted an R01 application and received an exceptional score. Three participants have NEI new investigator status. They are either on or just completed K- awards and will be submitting NEI R01 applications during this renewal period. Annually, NEI funds exceed $12.6 million, not including internal UAB awards. Extramural funding for vision-related research at UAB has grown to nearly $16.1 million annually. UAB vision scientists study visual neuroscience (anatomical, bio- chemical, physiological, or psychophysical studies of the retina, glaucoma, and central visual pathways), AMD, myopia, keratoconus, dry eye and cataractogenesis among others. Dr. Brian Samuels MD, PhD is the Director of the P30, now named the UAB Center Cores for Vision Research (CCVR), and the Administrative Core, and will have primary responsibility for all expenditures and proper functioning of the cores. He will coordinate with Dr. Steve Pittler, PhD, Director of the UAB institutionally supported Vision Science Research Center (VSRC) and co-director of the CCVR, to ensure the core resources and services align with participant needs. This application requests funds to provide continued support participants’ research activities through four professionally staffed cores. Each core, centrally located in Volker Hall, provides state-of-the-art facilities and expertise specifically for each purpose. The Machine Shop Core, directed by Paul Gamiln, PhD., designs and fabricates unique mechanical devices and repair/maintenance of current instruments. The Research Programming & Computational Analysis Core, directed by J. Crawford Downs, PhD, provides access to high-end analytical tools including advanced image and big-data analysis, computer programming, custom software/hardware development and interfacing, and database development/management. The Molecular & Cellular Analysis Core, directed by Steve Pittler, PhD., provides expertise for molecular and cellular study designs, training and access to major instrumentation for DNA, RNA and protein studies and morphologic analysis of tissues and cells. The Ocular Phenotyping Core, directed by Timothy Kraft, PhD, provides resources and services to assist with structural and functional analysis of small animal models of human ocular disease and study design and biostatistical analysis. Since 1979, vision research has received more than $19M in institutional support and more than $1M is committed over the next 5 years funding cycle. UAB has grown into a national leader in vision research by focusing on the use of advanced technology and the recruiting the best scientists to study and devise treatments for ocular disorders. The continuation of the P30 core grant for vision research is an essential element at the core of new discovery in vision science at UAB.

UAB 视觉研究中心 - 整体核心项目概要/摘要 1979 年，UAB 首次获得了 NEI 核心资助，在接下来的 41 年里，该机构致力于战略增长导致愿景研究的显着扩展，参与者从 13 人增加到 2 人。部门增至 3 个部门的 25 个，同时校外资金也增加了 20 名。目前持有 24 项符合资格的 NEI R01 补助金。一名参与者已提交 R01 申请并收到了一份。三位参与者拥有 NEI 新研究者身份，他们要么正在完成 K- 学业，要么刚刚完成 K- 学业。每年，NEI 资金都会超过。 1260 万美元，不包括 UAB 内部奖励，用于 UAB 视觉相关研究。 UAB 视觉科学家每年研究视觉神经科学（解剖学、生物科学）的资金增长到近 1610 万美元。视网膜、青光眼和中央视觉通路的化学、生理或心理物理学研究）、AMD、 Brian Samuels 医学博士、哲学博士是该中心的主任。 P30 的一部分，现命名为 UAB 视觉研究中心核心 (CCVR) 和管理核心，并对核心的所有支出和正常运作负主要责任。与 UAB 机构支持的视觉科学研究中心主任 Steve Pittler 博士合影 (VSRC) 和 CCVR 联合主任，以确保核心资源和服务符合参与者的需求。该申请要求资金通过四个方面为参与者的研究活动提供持续支持每个核心都配备了专业的人员，位于沃尔克大厅的中心，提供最先进的设施和由 Paul Gamiln 博士指导的 Machine Shop Core 专门针对每种用途进行设计和设计。制造独特的机械设备并修复/维护现有仪器。编程和计算分析核心，由 J. Crawford Downs 博士指导，提供访问高端分析工具，包括高级图像和大数据分析、计算机编程、定制软件/硬件开发和接口，以及数据库开发/管理。由 Steve Pittler 博士指导的细胞分析核心为分子和细胞研究提供专业知识设计、培训和使用用于 DNA、RNA 和蛋白质研究以及形态学的主要仪器 Timothy Kraft 博士指导的眼部表型分析核心提供了组织和细胞的分析。协助对人眼小动物模型进行结构和功能分析的资源和服务自 1979 年以来，视觉研究已获得超过 100 项研究成果。 UAB 已承诺在未来 5 年的资助周期内提供 1900 万美元的机构支持和超过 100 万美元的资金。通过专注于先进技术和应用的运用，成长为视觉研究领域的全国领先者招募最优秀的科学家来研究和设计眼部疾病的治疗方法 P30 的延续。视觉研究的核心资助是阿拉巴马大学视觉科学新发现的核心要素。

项目成果

期刊论文数量（558）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Glaucomatous Visual Field Progression in the African Descent and Glaucoma Evaluation Study (ADAGES): Eleven Years of Follow-up.

DOI：
10.1016/j.ajo.2022.02.003
发表时间：
2022-07
期刊：
AMERICAN JOURNAL OF OPHTHALMOLOGY
影响因子：
4.2
作者：
Melchior, Bruna;Valenzuela, Ives A.;de Moraes, C. Gustavo;Paula, Jayter S.;Fazio, Massimo A.;Girkin, Christopher A.;Proudfoot, James;Cioffi, George A.;Weinreb, Robert N.;Zangwill, Linda M.;Liebmann, Jeffrey M.
通讯作者：
Liebmann, Jeffrey M.

Scleral crosslinking using genipin can compromise retinal structure and function in tree shrews.

DOI：
10.1016/j.exer.2022.109039
发表时间：
2022-06
期刊：
EXPERIMENTAL EYE RESEARCH
影响因子：
3.4
作者：
El Hamdaoui, Mustapha;Levy, Alexander M.;Stuber, Aaron B.;Girkin, Christopher A.;Kraft, Timothy W.;Samuels, Brian C.;Grytz, Rafael
通讯作者：
Grytz, Rafael

Existence of deamidated alphaB-crystallin fragments in normal and cataractous human lenses.