Development of a photothermal stimulator array for controlled neuron stimulation

开发用于受控神经元刺激的光热刺激器阵列

• 批准号: 10411554
• 负责人: Sang-Woo Seo
• 金额: $ 13.42万
• 依托单位: CITY COLLEGE OF NEW YORK
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-05 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10411554
• 关键词: Address; Affect; Age related macular degeneration; American; Area; Biological Assay; Biological Process; Blindness; Cells; Complex; Corrosives; Development; Devices; Disease; Electric Stimulation; Electrodes; Engineering; Evaluation; Face; Generations; Genetic; Genetic Processes; Goals; Heating; Image; Light; Measurement; Measures; Methods; Microelectrodes; Modification; Monitor; Needles; Neurons; Optics; Patients; Pattern; Photoreceptors; Physiologic pulse; Reaction; Research; Resolution; Retina; Retinal Degeneration; Retinitis Pigmentosa; Signal Transduction; Structure; Techniques; Testing; Therapeutic; Toxic effect; Translating; absorption; base; biomaterial compatibility; calcium indicator; density; design; extracellular; flexibility; frontier; fundamental research; improved; nanoparticle; neural stimulation; novel; novel strategies; optical fiber; optogenetics; particle; plasmonics; relating to nervous system; response; retinal prosthesis; temporal measurement; time use; tool; two-dimensional

Project Summary/Abstract Retinal degenerative diseases, such as retinitis pigmentosa (RP) and age-related macular degeneration (AMD), affect more than 10 million Americans. Unfortunately, many patients eventually suffer vision loss due to no available therapeutic cure for these diseases. Retinal prosthesis is the only available option to make artificial interfaces to restore a damaged neural path. Electrical stimulation-based retinal prostheses have been most widely used due to their conceptual simplicity. However, it faces many hurdles due to complex signal interfaces, especially for high spatial resolution. A novel approach based on the principle of stimulating neuronal cells with a direct optical-induced thermal signal is introduced to potentially offer more advantages over the electrical stimulation approach. However, the concept is relatively new, and necessary engineered means should be developed to translate this approach to retinal prostheses. The goal of the proposed research is to create a two-dimensional array of photothermal pixels, of which the thermal stimulation is directly controlled by incoming light images. Based on the optical stimulation approach, this will address many challenges that the current electrical stimulation face, especially for large area stimulation. Successful completion of the proposed research will represent a revolutionary advance on the photothermal-based stimulation method and open a new opportunity of using photothermal stimulation in retinal prostheses.

项目摘要/摘要 视网膜变性疾病，例如色素性视网膜炎（RP）和与年龄相关的黄斑变性 （AMD），影响超过1000万美国人。不幸的是，许多患者最终由于 这些疾病没有可用的治疗方法。视网膜假体是唯一可用的选择 人工接口以恢复受损的神经路径。基于电刺激的视网膜假体 由于其概念上的简单性，最广泛使用。但是，由于复杂的信号，它面临许多障碍 界面，特别是用于高空间分辨率。一种基于刺激原理的新方法 引入具有直接光学诱导热信号的神经元细胞以提供更多优势 超过电刺激方法。但是，该概念是相对较新的，必要的设计的 应开发手段将这种方法转化为视网膜假体。提议的目标 研究是创建一个二维光热像素，其中热刺激直接 通过传入的光图像控制。基于光刺激方法，这将解决许多 当前电刺激面临的挑战，尤其是对于大面积刺激。成功的 拟议研究的完成将代表基于光热的革命性进步 刺激方法并打开在视网膜假体中使用光热刺激的新机会。