Aspen Lung Conference: Asthma: Pathogenesis, Phenotypes, Therapies and Gaps

阿斯彭肺部会议：哮喘：发病机制、表型、治疗方法和差距

• 批准号: 10680832
• 负责人: ANTHONY N GERBER
• 金额: $ 3万
• 依托单位: NATIONAL JEWISH HEALTH
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10680832
• 关键词: Address; Asthma; Award; Basic Science; Biology; Cells; Cellular biology; Clinical; Clinical Research; Dedications; Development; Discipline; Disease; Environmental Impact; Environmental Risk Factor; Ethnic Population; Exposure to; Future; Generations; Genetic; Grant; Immune; Immune system; Immunology; Infectious Agent; International; Knowledge; Lung; Lung diseases; Measures; Mentorship; Minority; Molecular; Oral; Pathogenesis; Patients; Phenotype; Prevalence; Productivity; Publishing; Research; Research Personnel; Role; Scientific Advances and Accomplishments; Scientist; Series; Therapeutic; Translating; Translational Research; Translations; Travel; Underrepresented Minority; Woman; career; cell type; diversity and inclusion; early-career faculty; effective therapy; improved; interest; lectures; lung health; microbiome; molecular phenotype; novel strategies; posters; pre-clinical; programs; public health relevance; racial population; success; symposium

PROJECT SUMMARY/ABSTRACT With an emphasis on the integration of basic, translational, and clinical approaches, the 65th annual Aspen Lung Conference will focus on a central question: how can knowledge of the molecular, genetic, and environmental mechanisms that underlie the development and phenotypic diversity of asthma be translated into more effective therapies? To address this central question, the program is organized into a series of thematic sessions, with State of the Art speakers framing each topic. The thematic sessions will focus on (i) the developmental origins of asthma, (ii) the role of cell biology in defining asthma endotypes, (iii) microbiome and immune mechanisms underlying asthma pathogenesis, (iv) integrated cell and molecular mechanisms contributing to the clinical complexity of asthma, and (v) the future of asthma therapeutics. By addressing these topics, we seek to accomplish the following: 1) provide an international forum for leading basic, translational, and clinical researchers to exchange ideas regarding the development and cell type specific roles of the airway and immune system in the phenotypic and molecular manifestations of asthma; 2) stimulate interactions between scientific fields to identify emerging and shared interests that may lead to more efficient and productive research; 3) enhance the likelihood of success in translation of preclinical scientific advances into direct patient benefit by developing novel strategies to better understand disease pathogenesis and implement scientific advances in the treatment of asthma; and 4) challenge and stimulate the scientific interests of trainees and attract a new generation of early career investigators into the broad field of asthma, as well as underlying subdisciplines including airway and lung immune cell biology, genetics, and environmental impacts. We have identified 12 outstanding thought leaders to present State of the Art lectures (35 min) on these topics. Each presentation will be followed by 25 minutes of discussion - a hallmark of the Conference. The program continues the Aspen Lung Conference’s dedication to diversity and inclusivity: n=8/13 (62%) of State of the Art speakers/Summarizer are women, and at least 6 of our speakers are from underrepresented racial/ethnic groups. Participation of trainees and early career faculty is facilitated by two 15-minute oral abstracts, selected from submitted abstracts, following each State of the Art speaker (24 total). There will be two evening poster sessions for further presentation opportunities by early career faculty and trainees. The final presentation is provided by a Conference Summarizer, who reviews the impact and common themes of the Conference. The Conference Summary will be published for widespread dissemination, to serve as a “think tank” that not only summarizes the current state of the field, but also identifies key future directions for basic, translational, and clinical asthma research. Finally, and notably, registration for the Aspen Lung Conference is free, encouraging participation from a wide spectrum of trainees and early career investigators.

项目摘要/摘要 重点是基本，跨性和临床方法的整合，第65届年度阿斯彭肺 会议将重点介绍一个中心问题：如何了解分子，遗传和 环境机制是哮喘的发展和表型多样性 转化为更有效的疗法，以解决这个中心问题 一系列主题会议，以最先进的扬声器为主题。 （i）哮喘的发育起源，（ii）细胞生物学在定义哮喘内型中的作用，（iii） 微生物组和免疫机制，哮喘发病机理，（iv）整合细胞和分子 有助于哮喘的临床复杂性的机制，以及（v）BYE的哮喘治疗方法。 解决主题，我们试图完成以下操作：1）为领导基本的国际论坛提供一个国际论坛 翻译和临床研究人员交换有关开发和细胞类型特定角色的想法 哮喘的表型和分子表现中的气道和免疫系统的刺激 科学领域之间的相互作用，以识别新兴和共同的利益，这些兴趣是蟾蜍提高效率的 3） 通过制定新型策略来更好地理解疾病发病机理和隐含性，直接患者受益 科学的哮喘治疗和4）挑战和刺激学员的科学利益 并吸引新一代的早期职业调查员进入广阔的哮喘领域以及基础 我们对气道和肺部免疫细胞生物学，遗传学和环境影响 确定了12个杰出的景象，以介绍这些主题的最新演讲（35分钟） 演讲将进行25分钟的讨论 - 该计划的标志 阿斯彭肺部会议对多样性和包容性的奉献：n = 8/13（62％）的最新状态 演讲者/摘要是女性，至少有6位发言人来自代表性不足的种族/族裔 团体的参与和早期护理职业教师由两个15分钟的口头摘要促进 从提交的摘要中，遵循每个先进的演讲者（总计24个）。 早期职业教师和学员的进一步演讲的会议。 由会议摘要的审查和会议的共同之处 会议摘要将出版以进行广泛传播，以作为“智囊团” 总结该领域的当前状态，但也标识了基本，翻译的关键未来方向 临床哮喘研究最终。 来自广泛的学员和早期职业调查员的参与。