Aspen Lung Conference: Asthma: Pathogenesis, Phenotypes, Therapies and Gaps

阿斯彭肺部会议：哮喘：发病机制、表型、治疗方法和差距

• 批准号: 10680832
• 负责人: ANTHONY N GERBER
• 金额: $ 3万
• 依托单位: NATIONAL JEWISH HEALTH
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10680832
• 关键词: Address; Asthma; Award; Basic Science; Biology; Cells; Cellular biology; Clinical; Clinical Research; Dedications; Development; Discipline; Disease; Environmental Impact; Environmental Risk Factor; Ethnic Population; Exposure to; Future; Generations; Genetic; Grant; Immune; Immune system; Immunology; Infectious Agent; International; Knowledge; Lung; Lung diseases; Measures; Mentorship; Minority; Molecular; Oral; Pathogenesis; Patients; Phenotype; Prevalence; Productivity; Publishing; Research; Research Personnel; Role; Scientific Advances and Accomplishments; Scientist; Series; Therapeutic; Translating; Translational Research; Translations; Travel; Underrepresented Minority; Woman; career; cell type; diversity and inclusion; early-career faculty; effective therapy; improved; interest; lectures; lung health; microbiome; molecular phenotype; novel strategies; posters; pre-clinical; programs; public health relevance; racial population; success; symposium

PROJECT SUMMARY/ABSTRACT With an emphasis on the integration of basic, translational, and clinical approaches, the 65th annual Aspen Lung Conference will focus on a central question: how can knowledge of the molecular, genetic, and environmental mechanisms that underlie the development and phenotypic diversity of asthma be translated into more effective therapies? To address this central question, the program is organized into a series of thematic sessions, with State of the Art speakers framing each topic. The thematic sessions will focus on (i) the developmental origins of asthma, (ii) the role of cell biology in defining asthma endotypes, (iii) microbiome and immune mechanisms underlying asthma pathogenesis, (iv) integrated cell and molecular mechanisms contributing to the clinical complexity of asthma, and (v) the future of asthma therapeutics. By addressing these topics, we seek to accomplish the following: 1) provide an international forum for leading basic, translational, and clinical researchers to exchange ideas regarding the development and cell type specific roles of the airway and immune system in the phenotypic and molecular manifestations of asthma; 2) stimulate interactions between scientific fields to identify emerging and shared interests that may lead to more efficient and productive research; 3) enhance the likelihood of success in translation of preclinical scientific advances into direct patient benefit by developing novel strategies to better understand disease pathogenesis and implement scientific advances in the treatment of asthma; and 4) challenge and stimulate the scientific interests of trainees and attract a new generation of early career investigators into the broad field of asthma, as well as underlying subdisciplines including airway and lung immune cell biology, genetics, and environmental impacts. We have identified 12 outstanding thought leaders to present State of the Art lectures (35 min) on these topics. Each presentation will be followed by 25 minutes of discussion - a hallmark of the Conference. The program continues the Aspen Lung Conference’s dedication to diversity and inclusivity: n=8/13 (62%) of State of the Art speakers/Summarizer are women, and at least 6 of our speakers are from underrepresented racial/ethnic groups. Participation of trainees and early career faculty is facilitated by two 15-minute oral abstracts, selected from submitted abstracts, following each State of the Art speaker (24 total). There will be two evening poster sessions for further presentation opportunities by early career faculty and trainees. The final presentation is provided by a Conference Summarizer, who reviews the impact and common themes of the Conference. The Conference Summary will be published for widespread dissemination, to serve as a “think tank” that not only summarizes the current state of the field, but also identifies key future directions for basic, translational, and clinical asthma research. Finally, and notably, registration for the Aspen Lung Conference is free, encouraging participation from a wide spectrum of trainees and early career investigators.

项目摘要/摘要 重点是基本，翻译和临床方法的整合，第65次年度阿斯彭肺 会议将重点介绍一个中心问题：如何知道分子，遗传和 哮喘的发展和表型多样性是环境机制 翻译成更有效的疗法？为了解决这个中心问题，该程序被组织成一个 一系列主题会议，最先进的演讲者构建了每个主题。主题会议将集中 （i）哮喘的发育起源，（ii）细胞生物学在定义哮喘内型中的作用，（iii） 哮喘发病机理上的微生物组和免疫机制，（iv）整合细胞和分子 有助于哮喘的临床复杂性的机制，以及（v）哮喘治疗的未来。经过 解决这些主题，我们试图完成以下任务：1）为领导基本的国际论坛提供 翻译和临床研究人员交换有关开发和细胞类型特定角色的想法 哮喘的表型和分子表现中的气道和免疫系统； 2）刺激 科学领域之间的相互作用，以识别可能导致更有效的新兴和共同利益 和生产研究； 3）增强了将临床前科学进步转化为成功的可能性 通过制定新型策略来更好地了解疾病发病机理和实施，直接患者福利 哮喘治疗的科学进步； 4）挑战和刺激学员的科学利益 并吸引新一代的早期职业调查员进入广阔的哮喘领域以及基础 子树学科，包括气道和肺部免疫菌株生物学，遗传学和环境影响。我们有 确定了12名杰出的思想领袖，以目前的现状讲座（35分钟）在这些主题上。每个 演讲将随后进行25分钟的讨论 - 会议的标志。该程序继续进行 阿斯彭肺部会议对多样性和包容性的奉献：n = 8/13（62％）的最新状态 演讲者/摘要是女性，我们至少有6位发言人来自代表性不足的种族/族裔 组。受训者和早期职业教师的参与是由两个15分钟的口头摘要准备的 从提交的摘要中，遵循每个先进的演讲者（总计24个）。将有两个晚上的海报 早期职业教师和学员的进一步演讲机会的会议。最后的演讲是 由会议摘要者提供，他审查了会议的影响和常见主题。这 会议摘要将出版以进行宽度传播，以充当一个“智囊团” 总结了该领域的当前状态，但也确定了基本，翻译和 临床哮喘研究。最后，值得注意的是，阿斯彭肺会议的注册是免费的，令人鼓舞 来自广泛的学员和早期职业调查员的参与。