Xenbase: a Xenopus Model Organism Knowledgebase

Xenbase：非洲爪蟾模型生物知识库

• 批准号: 10674802
• 负责人: PETER D VIZE
• 金额: $ 164.68万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10674802
• 关键词: ATAC-seq; Acceleration; Aloral; Animal Model; Atlases; Biological; Biomedical Research; Cells; Cellular biology; ChIP-seq; Communities; Computer software; Consumption; DNA methylation profiling; Data; Data Set; Databases; Development; Disease; Disease model; FAIR principles; Funding; Gene Expression; Gene Expression Process; Genes; Genomics; Genotype; Grant; Growth; Health; Human; Human Biology; Infrastructure; Investments; Knowledge; Letters; Link; Mission; Names; Operating System; Output; Paper; Phenotype; Play; Process; Proteomics; Publications; Publishing; Research; Research Personnel; Resources; Role; Source; Technology; Time; Translating; Translations; United States National Institutes of Health; Update; Variant; Visualization; Visualization software; XCL1 gene; XenBase; Xenopus; bioinformatics pipeline; bioinformatics tool; data exchange; data integration; data management; data mining; data sharing; empowerment; experience; experimental study; gene regulatory network; human DNA; human disease; human model; improved; knowledgebase; large scale data; model organism; mutant; novel; online resource; ontology development; phenotypic data; relational database; repository; tool; transcriptome sequencing; usability; user-friendly; web-accessible; xenopus genome

Component: OVERALL PROJECT SUMMARY/ABSTRACT Xenbase is the Xenopus Model Organism Knowledgebase (MOK), an online resource that integrates all genomic and biological data from Xenopus research. Our mission is to accelerate the translation of Xenopus research into knowledge that will improve human health. We aim to empower Xenopus research and enhance the impact of Xenopus data in the broader biomedical community, as animal models, such as Xenopus, are essential for biomedical research and have led to a wealth of discoveries. Xenbase is user-friendly, allowing investigators to quickly find and link different data types in ways that would otherwise be difficult, time consuming, or impossible. It provides high quality curation, data integration, and bioinformatics tools to link Xenopus data to humans and other model organisms, NCBI, UniProt, Ensembl and other resources. In this post genomic era, with thousands of scientific publications annually, and the exponential growth of “omic” datasets, Xenbase is essential to translate the enormous amount of data generated from research using Xenopus into meaningful connected data. Xenbase, thus, plays an essential role in maximizing NIH’s >$120 million annual investment in Xenopus research. Xenbase is an essential resource for hundreds of labs around the world. There is a clear need to continue curating Xenopus data, to develop new tools to keep up with technological advances, and link Xenopus data to human biology in novel and insightful ways. Many of the letters of support (more than 110) state that labs could not function without Xenbase, and renewed funding for Xenbase was identified as the top priority in the 2020 Xenopus research community white paper.

组件：总体 项目摘要/摘要 Xenbase是Xenopus模型有机体知识库（MOK），Anline资源 整合了来自Xenopus研究的所有基因组和生物学数据。 将Xenopus的研究翻译成我们的目标 增强Xenopus研究并增强爪蟾数据在更广泛的生物医学中的影响 社区作为Xenopus等动物模型对于生物医学研究和 导致了大量发现。 以否则困难，时间的方式查找并链接不同的数据类型，或 不可能。 对人类和其他模型生物，NCBI，Uniprot，Ensembl和其他模型的Xenopus数据 资源。 Xenbase的“ OMIC”数据集的指数增长可翻译大量 从Xenopus产生的数据到有意义的连接数据。 因此，在最大化NIH> 1.2亿美元的Xenopus投资中起着至关重要的作用 Xenbase是世界上数百个实验室的特别资源。 显然需要继续策划Xenopus数据，开发新工具以跟上 技术进步，并以新颖和有见地的方式将爪蟾数据与人类生物学联系起来。 许多支持信（更多 Xenbase和Xenbase的更新资金被确定为2020年的首要任务 Xenopus研究社区白皮书。