Core 2: Biostatistics and BioInformatics Core

核心2：生物统计学和生物信息学核心

• 批准号: 10673999
• 负责人: Menggang Yu
• 金额: $ 29.05万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-02 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10673999
• 关键词: Achievement; Adult; Applications Grants; Architecture; Area; Award; Bioinformatics; Biometry; Biostatistics Shared Resource; Cancer Center; Cancer cell line; Clinical; Clinical Research; Collaborations; Communities; Complex; Computer software; Consultations; Data; Data Analyses; Data Collection; Data Set; Database Management Systems; Databases; Dedications; Development; Ensure; Environment; Experimental Designs; Extramural Activities; Faculty; Formulation; Grant; Head and Neck Cancer; Human Resources; Image; Informatics; Information Dissemination; Infrastructure; Joints; Laboratories; Laboratory Study; Leadership; Malignant Neoplasms; Manuscripts; Maps; Medical Informatics; Methodology; Methods; Movement; Operative Surgical Procedures; Participant; Pathology; Pharmacotherapy; Procedures; Publications; Pythons; Radiation; Recommendation; Recording of previous events; Research; Research Design; Research Methodology; Research Personnel; Role; Secure; Specialist; Statistical Data Interpretation; System; Tissue Microarray; Translations; Triage; Universities; Validation; Wisconsin; Writing; archive data; career; clinical database; cost effective; cost efficient; data archive; data integrity; data management; data quality/integrity; data sharing; data standards; data warehouse; electronic data; empowerment; experience; experimental study; head and neck cancer patient; human error; informatics shared resource; programs; research study; success; translational cancer research

PROJECT SUMMARY The objective of the Biostatistics and Bioinformatics Core (Biostats Core) of the Wisconsin Head and Neck Cancer (HNC) SPORE is to promote excellence in HNC translational research by providing dedicated and outstanding biostatistical and bioinformatic consultation and collaborative support to the HN SPORE projects, Pathology Core, Administrative Core, and other investigators whose projects are supported under the Developmental Research and Career Enhancement Programs. This support and collaboration will include laboratory, translational, and clinical-based research, focusing on translation from laboratory studies to clinical studies. The Biostats Core will achieve its objective by supporting investigators and providing statistical, informatic, and data management expertise, thus enhancing the quality and ensuring the validity of the research undertaken in the HN SPORE. The Biostats Core will provide expertise in all stages of the research: from formulation of research questions through study experimental design, data collection and management, to data analysis, interpretation and dissemination of results through publications. The Specific Aims of the Core are: Aim 1. To maintain devoted collaboration with the HN SPORE investigators in the design of research studies, in analysis and interpretation of data, and in writing of scientific manuscripts disseminating the HN SPORE results to the scientific community. Aim 2. To upgrade the current HN SPORE data architecture to a single and unified environment that enhances the current database management activities to ensure the transparency and validity of statistical and bioinformatic analysis via centralized data management and standardization, confidential and secure data archiving and sharing, and data validation and consistency check. Aim 3. To conduct, when necessary, methodology research to develop new statistical and bioinformatic methods and software relevant to the HN SPORE projects.

项目摘要 威斯康星州头和颈的生物统计学和生物信息学核心（Biostats Core）的目的 癌症（HNC）孢子是通过提供专用和专用和 出色的生物统计学和生物信息咨询以及对HN孢子项目的协作支持， 病理核心，行政核心和其他研究人员，其项目得到了支持 发展研究和职业增强计划。这种支持和协作将包括 实验室，转化和基于临床的研究，重点是从实验室研究到临床的翻译 研究。 Biostats核心将通过支持研究人员并提供统计， 信息性和数据管理专业知识，从而提高了质量并确保研究的有效性 在HN孢子中进行。 Biostats核心将在研究的各个阶段提供专业知识： 通过研究实验设计，数据收集和管理来提出研究问题，到数据 通过出版物分析，解释和传播结果。 核心的具体目的是： 目的1。要与HN孢子研究人员保持虔诚的合作研究研究设计研究， 在分析和解释数据以及撰写科学手稿时传播HN孢子的 结果给科学界。 目标2。将当前的HN孢子数据架构升级到一个单一的统一环境 增强当前的数据库管理活动，以确保统计的透明度和有效性 以及通过集中数据管理和标准化，机密和安全的生物信息学分析 数据归档和共享，以及数据验证和一致性检查。 目的3。在必要时进行方法论研究以开发新的统计和生物信息 与HN孢子项目相关的方法和软件。