UCSF-UCB Tuberculosis Research Advancement Center (TRAC)

UCSF-UCB 结核病研究促进中心 (TRAC)

• 批准号: 10674698
• 负责人: JEFFERY S COX
• 金额: $ 96.85万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-02 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10674698
• 关键词: Acceleration; Address; Affect; Area; Award; Basic Science; Biomedical Research; Clinical; Clinical Research; Clinical Sciences; Collaborations; Communication; Communities; Complex; Conceptions; Consultations; Country; Data; Dedications; Development; Diagnosis; Diagnostic; Discipline; Doctor of Philosophy; Education; Environment; Epidemic; Equity; Faculty; Fostering; Funding; Future; Goals; Health Sciences; Human; Income; Infrastructure; Interdisciplinary Study; International; Intervention; Investigation; Laboratories; Laboratory Research; Lead; Leadership; Mentors; Mentorship; Mycobacterium tuberculosis; Peer Review; Peer Review Grants; Population Sciences; Positioning Attribute; Prevention; Productivity; Program Development; Research; Research Design; Research Personnel; Resources; Sampling; San Francisco; Scientist; Services; Site; System; Technical Expertise; Technology; Training; Training Programs; Tuberculosis; United States National Institutes of Health; Vaccines; career; career development; cohort; community center; community engagement; data management; design; experience; experimental study; flexibility; forging; human subject; improved; innovation; interdisciplinary collaboration; international partnership; member; mobile computing; multidisciplinary; next generation; operation; pathogen; prevent; programs; success; tool; tuberculosis treatment; voucher

PROJECT SUMMARY The overall goal of the proposed UC San Francisco – UC Berkeley Tuberculosis Research Advancement Center (UCSF-UCB TRAC) is to accelerate the pace of discoveries that improve our understanding of tuberculosis (TB) and lead directly to new tools for diagnosis, prevention, and treatment of TB. Addressing the complex problems of the current heavy burden and persistence of the TB epidemic requires partnerships across disciplines; mobilization of technology for identification, intervention, and prevention; and mentoring of future scientists and clinicians. The UCSF-UCB TRAC is uniquely positioned to address these challenges for radically new treatments, better diagnostics and an effective vaccine. UCSF and UCB represent a major hub of NIH-funded TB research with many labs across the wide spectrum of disciplines, and the UCSF-UCB TRAC will fill a critical gap in a prominent clinical and basic science research environment. Our proposed UCSF-UCB TRAC will allow us to, (1) attract and support New Investigators (NI) in the TB field by providing pilot awards, training, longitudinal mentorship and other key services and resources; and (2) attract and enable non-TB investigators to enter the field by providing awards, key resources and opportunities for multidisciplinary collaboration that support new directions in TB research. Further, our Center tightly integrates 4 cores: 1) an Administrative Core to provide leadership, infrastructure, administrative and communication support, advice and oversight to coordinate all UCSF-UCB TRAC operations; 2) a Basic Science Core to lower traditional barriers experienced by investigators to facilitate innovative, multidisciplinary, fundamental TB research through a suite of cutting edge technologies accessible in BSL-3/ABSL-3 facilities; 3) a Clinical Science Core to augment existing UCSF and UCB resources to accelerate clinical research by engaging new investigators and reducing the barrier to conducting high-quality, innovating clinical research; and 4) a Developmental Core to attract and develop scientific leaders in TB research via a platform of services to support a continuum of ideas to independence in TB research, offering mentoring, professional development, proposal support, and research funding. The UCSF-UCB TRAC will add value to the robust research enterprises of UCSF and UC Berkeley by bridging traditional silos between fundamental and clinical TB and by providing a nucleating factor for coordinated TB research resources and collaboration at the two campuses and at affiliated international research sites.

项目摘要 拟议的UC旧金山UC - UC Berkeley结核病研究进步中心的总体目标 （UCSF-UCB TRAC）是为了加速发现我们对结核病（TB）的发现空间 直接导致新工具用于诊断，预防和治疗结核病。解决复杂问题 目前，结核病流行的重烧和持久性需要跨学科的伙伴关系； 动员技术以识别，干预和预防；以及未来科学家的心理 临床医生。 UCSF-UCB TRAC的独特位置可以解决根本新的挑战 治疗，更好的诊断和有效的疫苗。 UCSF和UCB代表了NIH资助的主要枢纽 与广泛学科的许多实验室有关的结核病研究，UCSF-UCB TRAC将填补关键 在著名的临床和基础科学研究环境中的差距。我们提议的UCSF-UCB TRAC将允许 我们要（1）通过提供试点奖，培训，纵向，吸引并支持结核病领域的新调查员（NI） 指导和其他关键服务和资源； （2）吸引并使非TB调查人员进入 通过提供奖励，关键资源和跨学科合作的机会来支持新的领域 结核病研究方向。此外，我们的中心紧密整合了4个核心：1）提供的行政核心 领导，基础设施，行政和沟通支持，建议和监督以协调所有 UCSF-UCB TRAC操作； 2）降低调查人员经历的传统障碍的基本科学核心 通过一系列尖端技术促进创新的，多学科的基本结核病研究 可在BSL-3/ABSL-3设施中访问； 3）增加现有UCSF和UCB资源的临床科学核心 通过吸引新的研究人员并减少进行高质量的障碍来加速临床研究 创新临床研究； 4）一个发育核心，吸引和培养结核病研究中的科学领导者 通过服务平台来支持结核病研究中独立的思想的连续性，提供心理， 专业发展，建议支持和研究资金。 UCSF-UCB TRAC将为 通过在基本和 临床结核病并通过为协调结核病研究资源和协作的成核因素 两个校园和会员国际研究地点。