Research Training at the Confluence of Infectious and Non-Communicable Diseases in India

印度传染病和非传染性疾病交汇处的研究培训

• 批准号: 10361555
• 负责人: JEFFERY S COX
• 金额: $ 18.69万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-06-01 至 2023-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10361555
• 关键词: Acute respiratory infection; Address; Age; Applications Grants; California; Caring; Chronic; Cities; Collaborations; Communicable Diseases; Country; Data Analyses; Development; Diabetes Mellitus; Educational process of instructing; Educational workshop; Emerging Communicable Diseases; Epidemiology; Faculty; Frequencies; Goals; Human Resources; India; Institution; Laboratories; Medical; Mentors; Mentorship; Modernization; Molecular; Molecular Epidemiology; Population; Prevalence; Public Health; Research; Research Institute; Research Training; San Francisco; Scientist; Site; System; Technology; Training; Training Programs; Universities; Work; bacterial resistance; data management; epidemiology study; member; programs; public health research; respiratory; rural area; surveillance data

The goal of this 5-year Global Infectious Diseases (GID) training grant proposal is to establish a research and training program in India focused on the study of the interaction of infectious diseases (IDs) with non-communicable diseases (NCD). NCDs, such as diabetes and chronic respiratory illnesses, are rapidly increasing in prevalence in India as the middle class expands, the population ages, and modern medical care and technology become more accessible. However, IDs, including TB and acute respiratory infections, remain a substantial burden. India is also an important center for the development and spread of bacterial resistance. The high frequency of IDs combined with the substantial and growing burden of NCDs drives a need for Indian scientists with an expertise in NCD-associated infectious diseases (NCDAID). This program will be established at JSS University (JSSU), a medical teaching center in Mysore, Karnataka, India, that serves Mysore city and surrounding rural regions of South India. Collaborators include the Public Health Research Institute, India (PHRII), also located in Mysore, and the University of California at Berkeley (UCB) and San Francisco (UCSF). Key personnel at these institutions have ongoing projects and collaborations. This training program will expand the number of faculty and range of projects involved in these collaborations to include projects along two specific tracks: (1) field epidemiology and (2) molecular epidemiology. Projects will initially focus on infectious diseases associated with diabetes mellitus and chronic respiratory illnesses. Masters, medical, or doctoral candidate trainees in the field epidemiology track (1-2 per year) will train in the US for 6 months before returning to India to conduct their field work with support from PHRII and their JSSU mentors. Doctoral trainees will return to the US for up to 12 months to conduct advanced data analyses with their US mentors. We also propose to create a data surveillance and analysis/management system at JSSU that can serve as a long-term training site to study NCDAID in South India. The molecular epidemiology track will include the training of a junior faculty member in the US for 2 years, who will then return to establish a molecular epidemiology laboratory at JSSU. Then, each year a doctoral candidate will be trained for 12 months in the US who will then return to help establish and complete their research in the new JSSU facility. In-country workshops will be held annually for trainees and faculty in molecular epidemiology, data management and analysis, and mentorship. We thus plan to establish a long- term molecular and field epidemiological research capacity at JSSU that can address this emerging ID public health problem resulting from the increasing prevalence of NCDs in India.

这项为期5年的全球传染病（GID）培训补助金的目标是在印度建立研究和培训计划，重点是研究传染病（IDS）与非传染性疾病（NCD）的相互作用。随着中产阶级的扩大，人口年龄的增长，印度的糖尿病和慢性呼吸道疾病等NCD正在迅速增加，现代医疗和技术变得更加容易获得。但是，ID，包括结核病和急性呼吸道感染，仍然是一个很大的负担。印度还是细菌抗性发展和传播的重要中心。 ID的高频率加上NCD的实质性和日益增长的负担驱动了具有NCD相关感染性疾病（NCDAID）专业知识的印度科学家的需求。该计划将在印度卡纳塔克邦迈索尔的医学教学中心JSS大学（JSSU）建立，该中心为迈索尔市及其周围印度南部的农村地区提供服务。合作者包括位于迈索尔的印度公共卫生研究所（PHRII），以及加利福尼亚大学伯克利分校（UCB）和旧金山（UCSF）。这些机构的关键人员有持续的项目和合作。该培训计划将扩大这些合作中涉及的教职员工的数量和范围的项目范围，包括沿两个特定轨道的项目：（1）现场流行病学和（2）分子流行病学。最初，项目将集中于与糖尿病和慢性呼吸系统疾病有关的传染病。现场流行病学轨道（每年1-2）的硕士，医学或博士候选人学员将在美国训练6个月，然后返回印度在PHRII及其JSSU导师的支持下进行现场工作。博士学员将返回美国长达12个月，与他们的美国导师进行高级数据分析。我们还建议在JSSU创建一个数据监视和分析/管理系统，该系统可以作为在印度南部研究NCDAID的长期培训地点。分子流行病学轨道将包括对美国的一名初级教职员工进行2年的培训，然后他们将返回在JSSU建立分子流行病学实验室。然后，每年将在美国培训12个月的博士候选人，然后他们将返回以帮助在新的JSSU设施中建立和完成他们的研究。国内研讨会每年将为学员和分子流行病学，数据管理和分析以及指导的学员举行。因此，我们计划在JSSU建立长期的分子和现场流行病学研究能力，该研究可以解决这一新出现的ID公共卫生问题，这是由于印度NCD的越来越多。

项目成果

The Use of High-Flow Nasal Cannula and Non-Invasive Mechanical Ventilation in the Management of COVID-19 Patients: A Prospective Study.

• DOI: 10.3390/v15091879
• 发表时间: 2023-09-05
• 期刊: Viruses
• 作者: Arunachala S;Parthasarathi A;Basavaraj CK;Malamardi S;Chandran S;Venkataraman H;Ullah MK;Ganguly K;Upadhyay S;Mahesh PA
• 通讯作者: Mahesh PA

Armed conflict, HIV, and syndemic risk markers of mental distress, alcohol misuse, and intimate partner violence among couples in Uganda.

• DOI: 10.1002/jts.22740
• 发表时间: 2021-10
• 期刊: Journal of traumatic stress
• 影响因子: 3.3
• 作者: Mootz JJ;Basaraba CN;Corbeil T;Johnson K;Kubanga KP;Wainberg ML;Khoshnood K
• 通讯作者: Khoshnood K

Trends in the Bacterial Prevalence and Antibiotic Resistance Patterns in the Acute Exacerbation of Chronic Obstructive Pulmonary Disease in Hospitalized Patients in South India.

• DOI: 10.3390/antibiotics11111577
• 发表时间: 2022-11-09
• 期刊: Antibiotics (Basel, Switzerland)

Circulatory Serum Krebs von Den Lungen-6 and Surfactant Protein-D Concentrations Predict Interstitial Lung Disease Progression and Mortality.

• DOI: 10.3390/cells12091281
• 发表时间: 2023-04-28
• 期刊: Cells
• 影响因子: 6

Transactional sex work and HIV among women in conflict-affected Northeastern Uganda: a population-based study.

• DOI: 10.1186/s13031-022-00441-5
• 发表时间: 2022-02-25
• 期刊: Conflict and health
• 影响因子: 3.6
• 作者: Mootz JJ;Odejimi OA;Bhattacharya A;Kann B;Ettelbrick J;Mello M;Wainberg ML;Khoshnood K
• 通讯作者: Khoshnood K