TRAINING PROGRAM IN MACROMOLECULAR STRUCTURE AND MECHANISM

大分子结构与机理培训项目

• 批准号: 8695408
• 负责人: David L. Stokes
• 金额: $ 13.89万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8695408
• 关键词: Molecular Structure; Training Programs

DESCRIPTION (provided by applicant): This application seeks to establish a graduate training program in Macromolecular Structure and Mechanism at New York University School of Medicine (NYUSOM) leading to a Ph.D. degree. In this post-genomic era, detailed knowledge of macromolecules will lead to a fundamental understanding of information transfer, energy transduction and other basic mechanisms required of all biological systems. The proposed training program will combine early didactic course work, continuous mentorship from thesis committees and advisors with four years of hands-on research to prepare students for independent careers as biomedical scientists. The proposed program would represent a reconfiguration of an existing program in Structural Biology that was initiated 7 years ago with NYUSOM institutional support, namely from the Sackler Institute which oversees all graduate education at NYUSOM. To date, our existing program has graduated five students and currently contains 23 active students at various stages in their graduate studies. Four of these Students are from underrepresented minorities, reflecting the consistently high efforts by the Sackler Institute to increase the numbers and quality of minority applicants to NYUSOM. For the proposed program, we have identified 16 faculty that investigate macromolecular mechanisms using a variety of biophysical, biochemical and structural methods. These faculty can be grouped into four categories based on their research: signal transduction, membrane transport, regulation and assembly of nucleic acids, protein folding and design. These faculty have appointments in several different basic research departments at the School of Medicine and, in addition, in the Biology and Chemistry departments in the Faculty of Arts and Sciences, thus providing a highly interdisciplinary training environment. The proposed curriculum includes 1. specialized courses in the principles and methods of structural and molecular biology, 2. three research rotations, 3. formulation and defense of a research proposal, 4. continuous training and practice in research presentations, 5. discussions and lectures on ethical conduct in science and postgraduate career options, and 6. a rigorous research experience in a participating faculty member's laboratory. RELEVANCE: Detailed information about macromolecules is highly relevant to current trends in healthcare as the genome- wide sequencing gives way to investigations of the mechanisms by which biological systems function. Disease generally results from defects in or attacks on individual macromolecules; given detailed structural information, specific therapeutic agents can be designed to interfere with or ameliorate the consequences.

描述（由申请人提供）：本申请旨在在纽约大学医学院 (NYUSOM) 建立大分子结构和机制研究生培训项目，获得博士学位。程度。在这个后基因组时代，对大分子的详细了解将导致对信息传递、能量转换和所有生物系统所需的其他基本机制的基本理解。拟议的培训计划将结合早期的教学课程、论文委员会和顾问的持续指导以及四年的实践研究，为学生成为生物医学科学家的独立职业做好准备。拟议的计划将代表对结构生物学现有计划的重新配置，该计划于 7 年前在 NYUSOM 机构的支持下启动，即来自负责监督 NYUSOM 所有研究生教育的萨克勒研究所的支持。迄今为止，我们现有的项目已毕业 5 名学生，目前有 23 名处于研究生学习不同阶段的活跃学生。其中四名学生来自代表性不足的少数族裔，这反映出萨克勒研究所为提高 NYUSOM 少数族裔申请者的数量和质量而做出的持续努力。对于拟议的项目，我们已经确定了 16 名教师，他们使用各种生物物理、生物化学和结构方法研究大分子机制。这些教师根据他们的研究可以分为四类：信号转导、膜运输、核酸调节和组装、蛋白质折叠和设计。这些教师在医学院的几个不同的基础研究部门以及文理学院的生物和化学系任职，从而提供了高度跨学科的培训环境。拟议课程包括 1. 结构和分子生物学原理和方法的专业课程，2. 三个研究轮转，3. 研究计划的制定和答辩，4. 研究报告的持续培训和实践，5. 讨论和讲座科学道德行为和研究生职业选择，以及 6. 在参与教职人员实验室的严格研究经验。相关性：有关大分子的详细信息与当前医疗保健趋势高度相关，因为全基因组测序让位于对生物系统功能机制的研究。疾病通常是由单个大分子的缺陷或攻击引起的。给出详细的结构信息，可以设计特定的治疗剂来干扰或改善后果。