Clinical and Translational Science Center

临床和转化科学中心

• 批准号: 10673813
• 负责人: JULIANNE L IMPERATO-MCGINLEY
• 金额: $ 996.71万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-05 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10673813
• 关键词: Adoption; Animals; Area; Atmosphere; Award; Bioinformatics; Biomedical Research; COVID-19 pandemic; Center for Translational Science Activities; Child; Cities; Clinic; Clinical; Clinical Research; Clinical Sciences; Collaborations; Communication; Communities; Community Health; Community Networks; Community Outreach; Computer software; Country; Development; Device or Instrument Development; Discipline; Disease; Education; Educational process of instructing; Elderly; Ensure; Entrepreneurship; Ethics; Fostering; Funding; Future; Future Generations; Generations; Goals; Health; Home; Hospitals; Human; Informatics; Infrastructure; Institution; Medical center; Medicine; Memorial Sloan-Kettering Cancer Center; Multi-Institutional Clinical Trial; New York; New York City; Operative Surgical Procedures; Orthopedics; Pathway interactions; Population; Presbyterian Church; Preventive Medicine; Process; Program Development; Public Health; Published Comment; Radial; Research; Research Personnel; Research Training; Resources; School Nursing; Science; Self Stimulation; Series; Site; Special Hospitals; Special Population; Strategic Planning; Students; System; TNFSF15 gene; Training; Translating; Translational Research; Universities; Vaccination; Walking; Work; base; career; career development; clinical translation; collaborative environment; college; community based participatory research; community engagement; community organizations; computing resources; design; disability; equity, diversity, and inclusion; ethnic minority; graduate school; hackathon; health disparity; health inequalities; high standard; improved; innovation; invention; lectures; medical schools; multidisciplinary; novel; opioid epidemic; outreach; pandemic impact; precision medicine; programs; racial minority; research study; symposium; synergism; therapeutic development; translational research program; translational study; underserved area; underserved community; urban public health; urban school; vaccine hesitancy; virtual; web portal

Contact PD/PI: IMPERATO-MCGINLEY, JULIANNE L OVERALL PROJECT SUMMARY/SUMMARY The Weill Cornell Medicine Clinical and Translational Science Center’s (CTSC) future strategies are built on the considerable accomplishments achieved over the last 14 years, providing the translation of research and the generation of research ideas that pave the way for future innovations despite the effect of the pandemic on the medical school, with the city in lockdown for over 14 months. The plans for the next five years are devised to continue to develop the existing infrastructure and its initiatives, to add new ones, to enhance networking, and to improve diversity, equity, and inclusion. In so doing, we will continue to advance translational science to improve community health. With our multi-institutional hub of distinguished partners firmly in place, the strategic plans for the CTSC are geared to rapidly advance translational science discovery by: 1) Enhancing informatics to increase resource adoption, reduce roadblocks and streamline workflow through training, novel software, and new collaborations; 2) Improving health inequities, developing strong translational research engagement with communites, and preparing for health crises, like the COVID-19 pandemic, where the CTSC organized a vaccination hesitancy program and set up vaccination sites in underserved communities; 3) Continuing to develop our highly successful clinical and translational education programs through innovative and entrepreneurial multifaceted initiatives including training in health disparities and a new cross-hub KL2/TL1 collaboration with the Georgetown/Howard CTSA; and 4) Creating Team Science initiatives that promote inclusion across the CTSC. Innovative didactic opportunities will continue to be offered and expanded, such as seminars on innovation and entrepreneurship, the newest of which will be a collaborate with eLab on “Unmet Needs for Stimulating Device Development,” a five-part series which is designed to stimulate device development. The Pilot Translational and Clinical Studies program will be enhanced to target projects in device and therapeutics development, precision medicine and research in special populations while promoting collaborations between the community, community organizations and CTSC Investigators. The CTSC also offers educative opportunities that reach the broader community such as our Teaching Ethics Through Art program, while the Special Population Network (SPN) will expand to include community outreach studies and continue clinical research studies with a focus on the following populations: children, the elderly, ethnic and racial minorities and those with disabilities. Additionally, the Network Capacity Component will do more outreach to encourage local investigators to initiate multi-center clinical trials. The CTSC has also been extremely successful ensuring the availability of biostatisticians from all partners with expertise in diverse disease systems and with adequate computational resources to support the design and conduct of research studies performed within the CTSC. All of these initiatives allow the CTSC to accomplish its goal of translating science to improve public health more effectively and efficiently. Project Summary/Abstract Page 298 Contact PD/PI: IMPERATO-MCGINLEY, JULIANNE L

联系PD/PI：Imperato-Mcginley，Julianne L 全面的 项目摘要/摘要 Weill Cornell Medicine临床和转化科学中心（CTSC）的未来策略是建立在 在过去的14年中取得了相当大的成就，提供了研究的翻译和 尽管大流行对未来的创新铺平道路的一系列研究思想 医学院，纽约市在锁定中呆了14个月以上。未来五年的计划被设计为 继续开发现有的基础架构及其计划，以添加新基础架构，以增强网络和 改善多样性，公平性和包容性。这样，我们将继续将转化科学推向 改善社区健康。凭借我们杰出合作伙伴的多机构中心，该战略首先 CTSC的计划旨在快速推进转化科学发现：1）增强信息信息 为了增加资源采用，通过培训，新软件和 新合作； 2）改善健康不平等，发展强大的转化研究参与 社区，并为健康危机做准备，例如COVID-19大流行，CTSC组织了 疫苗接种犹豫计划并在服务不足的社区中建立疫苗接种地点； 3）继续 通过创新和 企业家多基础计划，包括健康分配培训和新的横毂KL2/TL1 与乔治敦/霍华德CTSA的合作； 4）创建促进的团队科学计划 包含在整个CTSC中。创新的教学机会将继续提供和扩展，例如 关于创新和企业家精神的半手，最新的将是与Elab合作的 刺激设备开发的需求，“旨在刺激设备的五部分系列 发展。试点翻译和临床研究计划将增强设备中的目标项目 以及促进特殊人群的治疗开发，精确医学和研究 社区，社区组织和CTSC调查人员之间的合作。 CTSC也提供 教育机会，通过艺术计划，诸如我们的教学道德等更广泛的社区， 而特殊人口网络（SPN）将扩展到包括社区外展研究并继续 临床研究的重点是以下人群：儿童，年长，种族和种族 少数民族和残疾人。此外，网络容量组件将对 鼓励当地研究人员启动多中心临床试验。 CTSC也非常成功 确保所有合作伙伴的生物统计学家的可用性 足够的计算资源，以支持在内部进行的研究和进行研究 CTSC。所有这些举措允许CTSC完成翻译科学以改善公众的目标 健康更有效地有效。 项目摘要/摘要页面298 联系PD/PI：Imperato-Mcginley，Julianne L

项目成果

Looking beyond carboplatin and paclitaxel for the treatment of advanced/recurrent endometrial cancer.

• DOI: 10.1016/j.ygyno.2022.10.012
• 发表时间: 2022-12
• 期刊: GYNECOLOGIC ONCOLOGY
• 影响因子: 4.7
• 作者: Rubinstein, Maria;Shen, Sherry;Monk, Bradley J.;Tan, David S. P.;Nogueira-Rodrigues, Angelica;Aoki, Daisuke;Sehouli, Jalid;Makker, Vicky
• 通讯作者: Makker, Vicky

Unmet mental health needs in patients with advanced B-cell lymphomas.

• DOI: 10.1017/s1478951521001164
• 发表时间: 2022-06
• 期刊: PALLIATIVE & SUPPORTIVE CARE
• 影响因子: 2.2
• 作者: Marte, Chrystal;George, Login S.;Rutherford, Sarah C.;Ouyang, Daniel Jie;Martin, Peter;Leonard, John P.;Trevino, Kelly M.
• 通讯作者: Trevino, Kelly M.

Obstetrical Complications and Long-Term Cardiovascular Outcomes.

• DOI: 10.1007/s11906-020-01102-9
• 发表时间: 2020-09-17
• 期刊: Current hypertension reports
• 影响因子: 5.6
• 作者: Savage M;Steitieh D;Amin N;Malha L;Chasen S
• 通讯作者: Chasen S

Research Priorities for Plasma and Platelet Transfusion Strategies in Critically Ill Children: From the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding.

• DOI: 10.1097/pcc.0000000000002859
• 发表时间: 2022-01-01
• 期刊: Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
• 作者: Nellis ME;Remy KE;Lacroix J;Cholette JM;Bembea MM;Russell RT;Steiner ME;Goobie SM;Vogel AM;Crighton G;Valentine SL;Delaney M;Parker RI;Pediatric Critical Care Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding (TAXI-CAB), in collaboration with the Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network
• 通讯作者: Pediatric Critical Care Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding (TAXI-CAB), in collaboration with the Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network

Underrepresentation of racial and ethnic minorities in cascade testing for hereditary cancer syndromes.

• DOI: 10.1038/s41431-023-01364-2
• 发表时间: 2023-07
• 期刊: European journal of human genetics : EJHG