Crump Preclinical Imaging Core

Crump 临床前成像核心

• 批准号: 8962028
• 负责人: James R. Heath
• 金额: $ 14.21万
• 依托单位: CALIFORNIA INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2020-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8962028
• 关键词: Animals; Area; Autoradiography; Biodistribution; Biological Markers; Biology; California; Cancer Center; Cells; Clinic; Clinical Research; Cyclotrons; Data; Data Analyses; Detection; Development; Evaluation; Faculty; Goals; Housing; Human Resources; Image; Imaging Techniques; Imaging technology; Institutes; Institution; Investigational New Drug Application; Kinetics; Label; Laboratories; Leadership; Malignant Neoplasms; Measures; Modeling; Monitor; Optics; Outcome; PET/CT scan; Patients; Phase; Positron-Emission Tomography; Postdoctoral Fellow; Preparation; Procedures; Production; Quality Control; Radio; Radiochemistry; Radiolabeled; Radiopharmaceuticals; Research; Research Personnel; Research Project Grants; Research Support; Resource Sharing; Rodent; Safety; Services; Site; Students; Technology; Testing; Therapeutic; Therapeutic Intervention; Time; Toxicology; Tracer; Training Support; Translating; Vertebrates; Work; abstracting; animal imaging; digital; dosimetry; drug discovery; experience; human data; human subject; imaging modality; imaging probe; in vivo imaging; innovation; instrumentation; member; microCT; microPET; microPET/CT; molecular imaging; nanosystems; non-invasive imaging; novel; operation; pre-clinical; programs; prototype; radiotracer; research study; response; treatment response; tumor metabolism

SHARED RESOURCE CORE CRUMP PRECLINICAL IMAGING TECHNOLOGY CENTER ABSTRACT: The Crump Preclinical Imaging Technology Center will provide comprehensive support for the in vivo imaging studies carried out in the NSBCC projects. Under the direction of Core Director Dr. Michael Phelps, the Imaging Center is comprised of two other faculty, Dr. Arion Hadjioannou and Dr. Jason Lee, and one full-time staff member. All faculty members have extensive experience and recognition in preclinical molecular imaging. The Imaging Center will provide all radio-labeled probes, perform all microPET and CT studies, and data analysis. In addition, they will provide support and training to investigators, including animal preparation and monitoring, quality control and the strictest safety measures. The goal of the Shared Resource Core is to provide advanced molecular imaging support to assess the kinetics of tumor metabolism and therapeutic outcome in response to therapeutic intervention. These experiments will consist of highly-controlled, serially- acquired PET and CT scans for both functional and anatomical assessment, respectively. Since the PET radio- labeled probe used is also widely available in the clinic, the preclinical imaging data acquired by the Shared Resource Core can be translated as biomarkers for evaluation of treatment response in patients.

共享资源核心 CRUMP 临床前成像技术中心 抽象的： 克伦普临床前成像技术中心将为活体成像提供全面支持 NSBCC 项目中进行的研究。在核心总监 Michael Phelps 博士的指导下， 影像中心由另外两名教员 Arion Hadjioannou 博士和 Jason Lee 博士以及一名全职教师组成 职员。所有教师在临床前分子成像方面都拥有丰富的经验和认可。 成像中心将提供所有放射性标记探针，执行所有 microPET 和 CT 研究以及数据 分析。此外，他们还将为研究人员提供支持和培训，包括动物准备和 监控、质量控制和最严格的安全措施。共享资源核心的目标是 提供先进的分子成像支持来评估肿瘤代谢和治疗的动力学 对治疗干预的反应结果。这些实验将包括高度控制的、连续的 获得 PET 和 CT 扫描，分别进行功能和解剖评估。自从 PET 无线电- 所使用的标记探针在临床上也广泛使用，通过共享采集的临床前影像数据 资源核心可以转化为评估患者治疗反应的生物标志物。