Developing Internet-Delivered, Mindfulness-based Intervention to Reduce HIV Risk and Promote Mental and Sexual Health among Young Adult MSM

制定基于互联网的正念干预措施，以降低艾滋病毒风险并促进年轻男男性接触者的心理和性健康

• 批准号: 10675151
• 负责人: Shufang Sun
• 金额: $ 16.84万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10675151
• 关键词: AIDS prevention; Address; Affect; Age; Biological Markers; Bisexual; Clinical; Clinical Trials; Distress; Educational workshop; Epidemic; Focus Groups; Funding; Gays; General Population; HIV; HIV risk; Hair; Health Promotion; Human immunodeficiency virus test; Hydrocortisone; Internet; Intervention; K-Series Research Career Programs; Longevity; Mental Health; Mentors; Mentorship; Methods; Minority Groups; Modeling; National Center for Complementary and Integrative Health; Phase; Physiology; Population; Protocols documentation; Psyche structure; Public Health; Public Health Schools; Randomized; Reading; Research; Research Personnel; Risk; Scientist; Sexual Health; Sexual and Gender Minorities; Strategic Planning; Stress; Stress and Coping; Testing; The Sun; Training; United States National Institutes of Health; Universities; Waiting Lists; Work; acceptability and feasibility; base; behavioral health; behavioral health intervention; biopsychosocial; career; clinical development; disorder prevention; efficacious intervention; evidence base; experience; feasibility trial; health disparity; high risk; innovation; men who have sex with men; mindfulness; mindfulness intervention; mindfulness-based stress reduction; minority stress; population health; primary outcome; psychological distress; research and development; secondary outcome; sexual risk behavior; social stigma; stress reduction; syndemic; young adult; young men who have sex with men

PROJECT SUMMARY Young men who have sex with men (YMSM; age 18-24) are disproportionately burdened by HIV. Minority stress and its “downstream” effects in YMSM, including mental health issues, sexual risk behaviors, and suboptimal HIV testing, contribute to syndemic risks surrounding HIV. Mindfulness-based interventions (MBI), adapted for HIV prevention among YMSM and online-based delivery, could offer a transdiagnostic, innovative, and scalable method to address this public health issue. Consistent with NCCIH’s scientific priority in Disease Prevention and Health Promotion across Lifespan and NIH’s Strategic Plan to Advance Research on the Health of Sexual and Gender Minorities, the current project targets distressed, high HIV risk YMSM and aims to mobilize MBI for HIV prevention, to reduce minority stress and promote mental and HIV-related behavioral health. Specifically, this K23 will provide support for early phase, exploratory clinical trial by adapting mindfulness-based stress reduction (MBSR) and conducting a feasibility trial among YMSM. Candidate: Dr. Sun is a clinical scientist with a research background in HIV prevention and mental health concerning minority populations. In recent years, she has pursued clinical and research development in mindfulness. Building on her prior work, she is applying for a five-year K23 Career Development Award to obtain training, mentorship, and research experience to become an expert in adapting and evaluating MBI to address HIV-related health disparities and an independent investigator capable of R01 funding. Mentoring: An excellent team of senior investigators serve as mentors on this proposal. Drs. Don Operario and Judson Brewer are co-primary mentors, who have complimentary expertise in HIV prevention for MSM and internet-based MBI for behavioral health. Three co-mentors bring expertise in internet-based HIV intervention with young adults (Dr. Larry Brown), mindfulness for population health (Dr. Eric Loucks), and stress physiology (Dr. Audrey Tyrka). Research: Guided by the ADAPT-ITT model, the proposed project aims to (1) adapt MBSR for distressed, high risk YMSM using focus groups with YMSM (n=30) and stakeholders (n=16), (2) refine the intervention protocol by administering adapted materials to distressed, high risk YMSM (n=18) via theatre testing, and (3) examine the feasibility and acceptability of the adapted iMBI for HIV prevention by randomizing 40 distressed, high-risk YMSM to the iMBI (n=20) and a waitlist condition (n=20). Primary outcomes are HIV testing and sexual risk behaviors. Secondary outcomes are stress biomarker (hair cortisol), psychological health, minority stress and coping. Trainings: Dr. Sun will receive tailored training in MBSR, intervention adaptation and implementation for YMSM, and a biopsychosocial-based understanding of stress through coursework, seminars, workshops, directed readings, and mentored research. Guided by an excellent mentorship team, these training and research experiences will establish the candidate’s career as an expert in HIV-related behavioral health through MBI. The candidate is institutionally supported by Brown University School of Public Health.

项目摘要 与男人发生性关系的年轻人（YMSM； 18-24岁）被艾滋病毒烧毁。少数民族 压力及其在YMSM中的“下游”影响，包括心理健康问题，性风险行为和 次优的HIV检测，导致围绕艾滋病毒的联合风险。基于正念的干预措施（MBI）， 适用于YMSM和在线交付中预防HIV的适用 以及解决这个公共卫生问题的可扩展方法。与NCCIH疾病的科学优先事项一致 预防和健康促进生命周期以及NIH的战略计划，以提高对 性行为和性别少数群体的健康，当前的项目目标是苦恼，高艾滋病毒风险YMSM，目标 动员MBI进行预防HIV，减轻少数群体压力并促进与心理和HIV相关的行为 健康。特别是，该K23将通过调整来为早期的探索性临床试验提供支持 基于正念的压力减轻（MBSR）并在YMSM中进行可行性试验。候选人：博士 Sun是一名临床科学家，具有艾滋病毒预防和心理健康的研究背景 人群。近年来，她在正念中追求临床和研究发展。建立 她的先前工作，她正在申请五年的K23职业发展奖，以获得培训，Mentalship， 和研究经验，成为适应和评估MBI以解决与HIV有关的健康的专家 差异和能够获得R01资金的独立调查员。指导：一支优秀的高级团队 调查人员在此提案中担任导师。博士。 Don Operario和Judson Brewer是共同的 导师，在MSM和基于Internet的MBI方面具有免费的HIV预防专业知识 健康。三名副官员在与年轻人的基于Internet的HIV干预方面具有专业知识（Larry博士 棕色），人口健康的正念（埃里克·卢克斯博士）和压力生理学（奥黛丽·泰尔卡博士）。 研究：在Adapt-Itt模型的指导下，拟议的项目旨在（1）适应MBSR的苦恼，高 使用YMSM（n = 30）和利益相关者（n = 16）的焦点组风险YMSM，（2）完善干预协议 通过通过剧院测试对不良风险YMSM（n = 18）进行调整材料，（3）检查 通过随机使40个困扰，高风险 YMSM到IMBI（n = 20）和候补列表条件（n = 20）。主要结果是艾滋病毒测试和性风险 行为。次要结果是压力生物标志物（皮质毛），心理健康，少数族裔压力和 应对。培训：Sun博士将接受MBSR的量身定制培训，干预适应和实施 对于YMSM，以及通过课程，半手赛，讲习班，基于生物心理社会的理解， 定向阅读和指导研究。在一支出色的指导团队的指导下，这些培训和 研究经验将确立候选人作为与HIV相关行为健康专家的职业 通过MBI。该候选人在布朗大学公共卫生学院的机构支持下。