Developing Internet-Delivered, Mindfulness-based Intervention to Reduce HIV Risk and Promote Mental and Sexual Health among Young Adult MSM

制定基于互联网的正念干预措施，以降低年轻男男性接触者的艾滋病毒风险并促进心理和性健康

• 批准号: 10082672
• 负责人: Shufang Sun
• 金额: $ 16.84万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10082672
• 关键词: AIDS prevention; Address; Adherence; Affect; Age; Alcohol or Other Drugs use; Anxiety; Benchmarking; Biological Markers; Bisexual; Clinical; Clinical Research; Clinical Trials; Communities; Counseling; Data; Development; Disclosure; Discrimination; Distress; Educational workshop; Epidemic; Evaluation; Feedback; Focus Groups; Foundations; Funding; Future; Gays; Grant; HIV; HIV Infections; HIV Seronegativity; HIV Seropositivity; HIV risk; Hair; Health; Health Promotion; Health Services; Health education; Home environment; Human immunodeficiency virus test; Hydrocortisone; Impulsivity; Individual; Internet; Intervention; K-Series Research Career Programs; Lead; Link; Longevity; Mental Depression; Mental Health; Mental disorders; Mentored Patient-Oriented Research Career Development Award; Mentors; Mentorship; Methods; Mindfulness Training; Minority; Modeling; Patient Self-Report; Persons; Phase; Physiological; Physiology; Population; Prevention strategy; Preventive Intervention; Process; Production; Protocols documentation; Provider; Public Health; Public Health Schools; Randomized; Reading; Research; Research Personnel; Resources; Risk; Sampling; Scientist; Series; Sexual Health; Stigmatization; Stress; Stress and Coping; Testing; The Sun; Training; Universities; Work; base; behavioral health; behavioral health intervention; biological adaptation to stress; biopsychosocial; career; clinical development; clinical efficacy; condomless anal sex; coping; design; disorder prevention; efficacy study; emotion dysregulation; evidence base; experience; feasibility trial; health disparity; high risk; improved; innovation; men who have sex with men; mindfulness; mindfulness intervention; mindfulness-based stress reduction; minority health; population health; pre-exposure prophylaxis; primary outcome; protocol development; psychological distress; psychological symptom; recruit; research and development; sample collection; service intervention; sexual risk behavior; social stigma; stress reduction; young adult; young men who have sex with men

PROJECT SUMMARY Young men who have sex with men (YMSM; age 18-34) are disproportionately burdened by HIV. Minority stress and its “downstream” effects in YMSM, including mental health issues, sexual risk behaviors, and suboptimal HIV testing, contribute to the syndemic risks surrounding HIV. Mindfulness-based interventions (MBIs), adapted for HIV prevention among YMSM and internet-based delivery to maximize reach and engagement, could offer an innovative and scalable method to address this public health issue. Consistent with NCCIH’s scientific priority in Disease Prevention and Health Promotion across Lifespan, the current project aims to develop an internet-delivered MBI for HIV prevention among distressed, high-risk YMSM. Specifically, this K23 will provide support for an early phase, exploratory clinical trial by adapting mindfulness-based stress reduction (MBSR) and conducting a feasibility trial among YMSM. Candidate: Dr. Sun is a clinical scientist with a research background in HIV prevention and mental health concerning minority populations and marginalized communities. In recent years, she has pursued clinical and research development in mindfulness. Building on her prior work, she is applying for a five-year K23 Career Development Award to obtain training, mentorship, and research experience to become an expert in adapting and evaluating internet-delivered MBI to address HIV-related health disparities and an independent investigator capable of R01 funding. Mentoring: A stellar team of senior investigators serve on the advisory panel. Drs. Don Operario and Judson Brewer are co-primary mentors, who have complimentary expertise in HIV prevention for MSM and internet-based MBI for behavioral health. Three co-mentors bring expertise in internet-based HIV intervention with young adults (Dr. Larry Brown), mindfulness for population health (Dr. Eric Loucks), and stress physiology (Dr. Audrey Tyrka). Research: Guided by the ADAPT-ITT model, the proposed project aims to (1) adapt MBSR for distressed, high risk YMSM and internet-delivery using focus groups with YMSM (n=30) and stakeholders (n=16), (2) refine the intervention protocol by administering adapted materials to distressed, high risk YMSM (n=18) and stakeholders (n=16) via theatre testing, and (3) examine the feasibility and acceptability of the adapted iMBI for HIV prevention by randomizing 40 distressed, high-risk YMSM to the iMBI (n=20) and a Health Education condition (n=20). The study will examine recruitment and retention, intervention adherence (e.g., attendance, at-home practice), completion of assessment (HIV testing, sexual risk behaviors, hair sample collection, mental health, minority stress and coping), and acceptability of the intervention. Trainings: Dr. Sun will receive training in MBSR, intervention adaptation and implementation for YMSM and internet-delivery, and a biopsychosocial-based understanding of stress through coursework, seminars, workshops, directed readings, and mentored research. Guided by an excellent mentorship team, these training and research experiences will establish the candidate’s career as an expert in HIV-related behavioral health and iMBI for minority health. The candidate is institutionally supported by Brown University School of Public Health.

项目摘要 与男人发生性关系的年轻人（YMSM； 18-34岁）被艾滋病毒烧毁。少数派压力及其在YMSM中的“下游”影响，包括心理健康问题，性风险行为和次优的HIV测试，促进了围绕HIV的辛迪克斯蒂姆风险。基于正念的干预措施（MBI）适用于YMSM和基于Internet的交付以最大程度地提高覆盖范围和参与度的艾滋病毒预防，可以提供一种创新且可扩展的方法来解决这一公共卫生问题。与NCCIH在整个生命周期中的疾病预防和健康促进方面的科学优先级相一致，目前的项目旨在开发互联网销售的MBI，以预防困扰的高风险YMSM中的HIV预防艾滋病毒。具体而言，该K23将通过调整基于正念的压力减轻（MBSR）并在YMSM中进行可行性试验来为早期的探索性临床试验提供支持。候选人：Sun博士是一位临床科学家，在艾滋病毒预防和心理健康方面具有研究背景，涉及少数群体和边缘化社区。近年来，她在正念中追求临床和研究发展。在她先前的工作的基础上，她正在申请五年的K23职业发展奖，以获得培训，指导和研究经验，以成为适应和评估互联网服务的MBI的专家，以解决与HIV相关的健康差异以及能够获得R01资金的独立研究者。指导：高级调查员的出色团队在咨询小组中任职。博士。 Don Operario和Judson Brewer是共同的主要导师，他们在MSM和基于Internet的MBI方面具有免费的HIV预防专业知识，以实现行为健康。三名副主张为与年轻人（Larry Brown博士），人口健康（Eric Loucks博士）和压力生理学（Audrey Tyrka博士）（Audrey Tyrka博士）（Audrey Tyrka博士）提供了基于Internet的HIV干预的专业知识。研究：在适应性-ITT模型的指导下，拟议项目的目的是（1）使用具有YMSM（n = 30）的焦点组（n = 30）和利益相关者（n = 16）的焦点组来调整遇到的苦难，高风险YMSM和Internet交付，（2）通过对遇险的，高风险YMMM（n = 18）进行调整（2）进行干预方案（N = 18），N = 18）（N = 18）（N = 18）= 16）通过将40个受苦的高风险YMSM随机与IMBI（n = 20）和健康教育状况（n = 20）随机化40个遇到的高风险YMSM，可行性和可接受性用于预防HIV。该研究将检查招聘和保留率，干预依从性（例如出勤率，家庭实践），评估完成（HIV测试，性风险行为，收集头发样本，心理健康，少数群体压力和应对）以及干预的可接受性。培训：Sun博士将接受MBSR的培训，YMSM和Internet交付的干预适应和实施，以及通过课程，半音证，讲习班，定向阅读和心理研究对压力的基于生物心理社会的理解。这些培训和研究经验在出色的心态团队的指导下，将确立候选人的职业生涯，成为与艾滋病毒相关的行为健康和IMBI的专家。该候选人在布朗大学公共卫生学院的机构支持下。