NIDCD National Temporal Bone Hearing and Balance Pathology Resource Registry

NIDCD 国家颞骨听力和平衡病理学资源登记处

基本信息

批准号：
10673034
负责人：
M. Charles Liberman
金额：
$ 76.66万
依托单位：
MASSACHUSETTS EYE AND EAR INFIRMARY
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-09-01 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10673034
关键词：
Algorithms Archival Collection Autopsy Cessation of life Collection Confocal Microscopy DNA Data Databases Development Diagnosis Disease Doctor of Medicine Doctor of Philosophy Education Education and Outreach Enrollment Equilibrium Evaluation Facial nerve structure Gene Expression Hearing Hearing problem Histologic Histopathology Human Image Immunofluorescence Immunologic Label Laboratories Life Magnetic Resonance Imaging Maintenance Medical History Medical Records Medicine Methodology Methods Microscopy Mission Modality Modernization Molecular Genetics National Institute on Deafness and Other Communication Disorders Organ Procurements Pathologic Pathology Physicians Principal Investigator Process Proteomics Registries Research Research Personnel Resources Scientist Specialist Specimen Techniques Temporal bone structure experience human subject imaging approach improved interest member preservation programs recruit searchable database synchrotron radiation

项目摘要

Project Summary A comprehensive program is proposed to facilitate 1) recruitment of human temporal bone donors, 2) accrual and distribution of donated specimens to active laboratories, 3) development and maintenance of searchable de-identified databases including diagnoses, histopathological summaries, audiometric data and complete sets of digitized images, 4) brokering of special needs of research investigators using human otologic material, and 5) educational efforts including educational outreach to the public and interested professionals including scientists and organ procurement specialists and undertakers. As has been the case for the last 26 years, this will be accomplished through the maintenance and enhancement of a coordinated Temporal Bone Registry Office. The proposed Registry function will be overseen by Felipe Santos, M.D. (Principal Investigator) with assistance from Alicia Quesnel, M.D. (Co-Prinicpal Investigator) and M. Charles Liberman, Ph.D. (Co- Principal Investigator). Additional input will be solicited from other Departmental members with experience and professional interest in furtherance of human temporal bone histopathology, including D. Bradley Welling, M.D., Ph.D and Joseph B. Nadol, M.D. Additional oversight will be provided by the NIDCD Program Coordinator for the Registry who will help in the selection of a Steering Committee including the PI of the Registry, the Project Coordinator and 2 to 3 external scientists with an understanding and appreciation of the value of otopathology and basic otologic research.

项目摘要提出了一个综合计划来促进1）招募人类颞骨捐助者，2）应计和分配给活跃实验室的捐赠标本，3）开发并维护可搜索的去识别数据库，包括诊断，组织病理学摘要，听力数据和完整的数字化图像集，4）特殊的经纪研究研究人员使用人类耳科材料的需求，5）教育工作包括向公众和感兴趣的专业人士进行的教育宣传，包括科学家和器官采购专家和承办人。与过去26年一样将通过维护和增强协调的时间来实现骨注册处。拟议的注册表功能将由医学博士Felipe Santos监督。（主要研究人员）在Alicia Quesnel的协助下 M. Charles Liberman博士（共同研究员）。其他输入将从其他有经验和专业兴趣促进人类的部门成员颞骨组织病理学，包括D. Bradley Welling，医学博士，博士学位和Joseph B. Nadol，医学博士 NIDCD计划协调员将为注册表提供其他监督将有助于选择包括注册表的PI在内的指导委员会，该项目协调员和2至3位外部科学家，了解和欣赏的价值耳病学和基本的耳科研究。

项目成果

期刊论文数量（50）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Assessing fractional hair cell survival in archival human temporal bones.

评估档案人类颞骨中毛细胞的存活率。

DOI：
10.1002/lary.27991
发表时间：
2020
期刊：
The Laryngoscope
影响因子：
0
作者：
Wu,Pei-Zhe;Wen,Wei-Ping;O'Malley,JenniferT;Liberman,MCharles
通讯作者：
Liberman,MCharles

Peripheral Vestibular Organ Degeneration After Temporal Bone Fracture: A Human Otopathology Study.

颞骨骨折后周围前庭器官退化：人类耳病理学研究。

DOI：
10.1002/lary.28010
发表时间：
2020
期刊：
The Laryngoscope
影响因子：
0
作者：
Knoll,RenataM;Ishai,Reuven;Lubner,RoryJ;Trakimas,DanielleR;Brodsky,JacobR;Jung,DavidH;Rauch,StevenD;NadolJr.,,JosephB;Remenschneider,AaronK;Kozin,ElliottD
通讯作者：
Kozin,ElliottD

Histopathological changes to the peripheral vestibular system following meningitic labyrinthitis.

脑膜迷路炎后周围前庭系统的组织病理学变化。

DOI：
10.1002/lio2.349
发表时间：
2020
期刊：
Laryngoscope investigative otolaryngology
影响因子：
1.9
作者：
Pauna,HenriqueF;Knoll,RenataM;Lubner,RoryJ;Brodsky,JacobR;Cushing,SharonL;Hyppolito,MiguelA;NadolJr,JosephB;Remenschneider,AaronK;Kozin,ElliottD
通讯作者：
Kozin,ElliottD

Histopathology of the Inner Ear in a Case With Recent Onset of Cogan's Syndrome: Evidence for Vasculitis.

近期发生科根综合征的内耳组织病理学：血管炎的证据。