Resource Center for Human Temporal Bone Research, Innovation, and Education

人类颞骨研究、创新和教育资源中心

• 批准号: 10705764
• 负责人: Meredith Evelyn Adams
• 金额: $ 92.52万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-16 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10705764
• 关键词: Address; Affect; Anatomy; Archival Collection; Auditory; Autopsy; Awareness; Biological; Bone Tissue; Clinical; Clinical Research; Collaborations; Collection; Communities; Consumption; Course Content; DNA; Databases; Decalcification; Dedications; Disease; Drug or chemical Tissue Distribution; Ear; Ear Diseases; Education; Education and Outreach; Equilibrium; Genomics; Genotype; Goals; Hearing; Human; Human Resources; Hybrids; Image; Instruction; Investigation; Knowledge; Laboratories; Lasers; Learning Module; Methods; Microtomy; Molecular; Multimedia; National Institute on Deafness and Other Communication Disorders; Newsletter; Pathology; Persons; Phenotype; Preparation; Prevention; Procedures; Process; Proteins; Protocols documentation; Publications; RNA; Registries; Research; Research Personnel; Resources; Scholarship; Scientist; Services; Site; Source; Specialist; Specimen; Speed; Structure; Techniques; Technology; Temporal bone structure; Testing; Time; Tissues; Training; Universities; Vestibular Function Tests; Visualization; Work; cost; design; digital repositories; experience; image processing; imaging facilities; improved; innovation; inter-institutional; interest; medical specialties; meetings; multidisciplinary; outreach; preservation; programs; sample fixation; skills; social media; tissue processing; training opportunity; virtual; web site

ABSTRACT The study of the human temporal bone has proven to be incredibly powerful and is responsible for much of what we know about the anatomy and pathology of the ear. However, propagation of otopathology research has been hampered by barriers that affect every step of the research chain (procurement, processing, distribution, and dissemination). The major goals of this project are to propagate the use of human temporal bones for research and training through the establishment of our lab as national resource for temporal bone expertise and to become part of the collaborative network to be established by the NIDCD to serve the auditory and vestibular research communities. These goals will be achieved through 4 specific aims. In Specific Aim 1, we will establish a core service for processing and distribution of high-quality temporal bone tissue. We will leverage our high procurement capacity, digitization of our collection, and technical experience to implement a structured approach for prioritizing and processing human temporal bones that are of special scientific interest to meet research needs of the scientific community. In Specific Aim 2, we will optimize human temporal bone preparation techniques to reduce processing costs and time and improve the capacity to retain, preserve, and extract proteins and DNA/RNA. We will investigate technologies for improving the speed and quality achieved during fixation, embedding, decalcification, sectioning, and visualization. In Specific Aim 3, we will provide technical instruction on the processing and use of human temporal bones for the scientific and clinical communities. Innovative hybrid educational modules will be employed, and all materials, training, and protocols will be freely disseminated to increase the number of well-trained technicians and researchers. In Specific Aim 4, we will provide outreach to the scientific and clinical communities to disseminate and promote the use of human temporal bones in research. This will be achieved in-person at major scientific meetings and virtually using multiple multimedia resources. Our multidisciplinary team of experienced investigators has the necessary knowledge and skills aligned with ample resources (large archival collection, high procurement capacity of high-quality temporal bones, highly skilled team of technicians, internal distribution services to send biological specimens), collaborations with centers of excellence for imaging and tissue processing, and innovative educational and audiovisual services to provide the necessary means to propagate and take temporal bone research to the next level.

抽象的 事实证明，对人类颞骨的研究非常强大，并且负责大部分内容 我们知道耳朵的解剖学和病理学。但是，眼科病理研究的传播已经 受到影响研究链的每个步骤的障碍（采购，处理，分销和 传播）。该项目的主要目标是传播人类颞骨进行研究 并通过建立我们的实验室作为暂时骨骼专业知识的国家资源，并成为培训 NIDCD将建立的协作网络的一部分，以服务听觉和前庭研究 社区。这些目标将通过4个特定目标实现。在特定目标1中，我们将建立一个核心 用于处理和分布高质量颞骨组织的服务。我们将利用我们的高 采购能力，收集的数字化以及实施结构化方法的技术经验 用于优先和处理具有特殊科学利益的人类颞骨头 科学界的需求。在特定目标2中，我们将优化人类颞骨制备 减少加工成本和时间并提高保留，保存和提取蛋白质的能力的技术 和DNA/RNA。我们将研究改善注定期间速度和质量的技术， 嵌入，脱钙，切片和可视化。在特定目标3中，我们将提供技术指导 关于对科学和临床社区的人类颞骨的加工和使用。创新的混合动力 将采用教育模块，所有材料，培训和协议将被自由传播到 增加训练有素的技术人员和研究人员的数量。在特定的目标4中，我们将向 科学和临床群落在研究中传播和促进人类颞骨的使用。 这将在大型科学会议上进行面对面，并实际上使用多种多媒体资源。 我们经验丰富的研究人员的多学科团队具有与之一致的必要知识和技能 充足的资源（大型档案收集，高品质颞骨的高采购能力，高度 熟练的技术人员团队，内部分销服务以发送生物标本），与 成像和组织处理的卓越中心以及创新的教育和视听服务 提供必要的手段，将颞骨研究提升到一个新的水平。