Scientific Core

科学核心

• 批准号: 10641792
• 负责人: M. Charles Liberman
• 金额: $ 2.18万
• 依托单位: MASSACHUSETTS EYE AND EAR INFIRMARY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-02 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10641792
• 关键词: 3-Dimensional; Acoustics; Animal Experiments; Animals; Area; Automation; Center Core Grants; Clinical Research; Cochlea; Collaborations; Communication; Communities; Computer software; Consumption; Custom; Devices; Diagnosis; Discipline; Electronics; Encapsulated; Endowment; Engineering; Environment; Fees; Funding; Future; Generations; Goals; Hearing; Histologic; Histology; Home; Human; Human Resources; Image; Individual; Infrastructure; Joints; Knowledge; Laboratories; Leadership; Licensure; Microscope; Mus; National Institute on Deafness and Other Communication Disorders; Nature; Operative Surgical Procedures; Participant; Phase; Preparation; Prevalence; Productivity; Program Research Project Grants; Protocols documentation; Recording of previous events; Research; Research Personnel; Research Project Grants; Resources; Science; Scientist; Sensorineural Hearing Loss; Services; Stimulus; Structure; System; Technical Expertise; Techniques; Technology; Time; Tinnitus; Training; United States National Institutes of Health; Wages; Writing; cochlear synaptopathy; commune; computerized data processing; data acquisition; deafness; design; digital imaging; experience; imaging software; innovation; interdisciplinary collaboration; mechanical device; member; morphometry; novel; novel strategies; programs; public health relevance; reconstruction; repository; software systems; sound; success

Scientific Core – Summary Abstract The Scientific Core of our P50 Clinical Research Center builds on the long history of shared infrastructure at the Eaton-Peabody Laboratories, and consists of three Research Cores led by PI Liberman: 1) an Engineering Core to design, build, program and maintain data-acquisition systems, custom acoustical devices, and stimulus generation systems, to provide a precision machining service to build custom mechanical devices for a wide variety of research applications, and to share these software and hardware advances with the greater scientific community; 2) a Histology-Surgery Core to maintain and stock a shared wet-lab facility for histological processing and shared animal-surgery facilities, along with controlled substance licensure, to train new users on histological and surgical techniques and to continually enhance the quality of histological preparation throughout the Center; and 3) an Imaging Core to maintain and train users on the shared confocal and epifluoresence microscopes, and to support digital image-acquisition and analysis, via commercial software packages or, when necessary, via creation of custom software to allow further automation of morphometry and 3-D reconstruction and rendering. The communal nature of the Cores provide a number of significant benefits including: 1) enhancing inter-group communication, 2) providing economy of scale, 3) eliminating duplication of effort involved maintaining separate Investigator-based facilities, 4) helping investigators incorporate new approaches into their repertoire, based on the sharing of technical expertise across researchers and disciplines, and 5) allowing the creation of shared hardware and software systems with capabilities far beyond that achievable by individual PIs working in isolation.

科学核心 - 摘要摘要 我们P50临床研究中心的科学核心建立在共享的悠久历史上 Eaton-Peabody Laboratories的基础设施，由三个研究核心组成 PI Liberman：1）设计，构建，编程和维护数据获取的工程核心 系统，自定义声学设备和刺激生成系统，以提供精度 加工服务以构建用于各种研究的自定义机械设备 应用程序，并与更大的科学分享这些软件和硬件的进步 社区; 2）一种组织学手术核心，以维护和库存共享湿lab设施 组织学处理和共享动物手术设施以及受控的受试者 许可，培训新用户的组织学和手术技术，并不断增强 整个中心的组织学准备质量； 3）维护成像核心 并培训用户共享共同的共同焦点和荧光显微镜，并支持数字 图像获得和分析，通过商业软件包或必要时通过 创建自定义软件以进一步自动化形态计量学和3-D重建 和渲染。 核心的共同性提供了许多重要好处，包括：1） 加强小组间沟通，2）提供规模经济，3）消除重复 努力涉及维护单独的基于研究者的设施，4）帮助调查人员 根据分享技术专长，将新方法纳入其曲目 在研究人员和学科之间，以及5）允许创建共享硬件和 具有功能的软件系统远远超出了单个PI所实现的功能 隔离。